A5091790444- Obsessive-Compulsive Spectrum Disorders
- Autism Spectrum Disorder Research
- Eating Disorders and Behaviors
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Body Image and Dysmorphia Studies
- Functional Brain Connectivity Studies
- Neurological disorders and treatments
- Attention Deficit Hyperactivity Disorder
- Child and Adolescent Psychosocial and Emotional Development
- Neural and Behavioral Psychology Studies
- Stress Responses and Cortisol
- Treatment of Major Depression
- Neurotransmitter Receptor Influence on Behavior
- Psychology of Moral and Emotional Judgment
- Transcranial Magnetic Stimulation Studies
- Sexuality, Behavior, and Technology
- Mental Health Research Topics
- Olfactory and Sensory Function Studies
- Botulinum Toxin and Related Neurological Disorders
- Gut microbiota and health
- Gambling Behavior and Treatments
- Tryptophan and brain disorders
- Child Abuse and Trauma
- Genetic Associations and Epidemiology
- Perfectionism, Procrastination, Anxiety Studies
Institut d'Investigació Biomédica de Bellvitge
2015-2024
Bellvitge University Hospital
2015-2024
Instituto de Salud Carlos III
2015-2024
Universitat de Barcelona
2011-2024
Centro de Investigación Biomédica en Red de Salud Mental
2015-2024
New York Psychoanalytic Society and Institute
2017
Columbia University
2017
Universitat Autònoma de Barcelona
2015-2017
Hospital Del Mar
2015-2017
Hospital del Mar Research Institute
2017
Article AbstractBackground: The aim of our study was to assess whether there is a relationship between reproductive cycle events and the initiation or changes in symptoms obsessive-compulsive disorder (OCD). Method: Forty-six female outpatients meeting DSM-IV criteria for OCD completed semistructured interview at unit OCD. Dates data collection were from January 2001 December 2003. Results: In sample, onset occurred same year as menarche 22% (N = 10), pregnancy 2% 1), postpartum 7% 3),...
The aim of our study was to assess the role gender in OCD symptom dimensions with a multivariate analysis while controlling for history tic disorders and age at onset OCD. One hundred eighty-six consecutive outpatients DSM-IV diagnosis were interviewed. Yale-Brown Obsessive-Compulsive Scale (YBOC-S), YBOC-S Symptom Checklist, Hamilton Depression Anxiety Scales administered all patients. Lifetime assessed inventory section Yale Global Tic Severity Scale. Age by direct interview. Statistical...
Despite knowledge of amygdala involvement in fear and anxiety, its contribution to the pathophysiology obsessive-compulsive disorder (OCD) remains controversial. In context neuroimaging studies, it seems likely that heterogeneity might have contributed a lack consistent findings.To assess influence OCD symptom dimensions on responses well-validated emotional face-matching paradigm.Cross-sectional functional magnetic resonance imaging (fMRI) study 67 patients with age-, gender-...
<h3>Context</h3>Heightened moral sensitivity seems to characterize patients with obsessive-compulsive disorder (OCD). Recent advances in social cognitive neuroscience suggest that a compelling relationship may exist between this disorder-relevant processing bias and the functional activity of brain regions implicated OCD.<h3>Objective</h3>To test hypothesis OCD demonstrate an increased response relevant ventromedial prefrontal orbitofrontal cortex magnetic resonance imaging study difficult...
Abstract Deep brain stimulation (DBS) has been proposed for severe, chronic, treatment-refractory obsessive-compulsive disorder (OCD) patients. Although serious adverse events can occur, only a few studies report on the safety profile of DBS psychiatric disorders. In prospective, open-label, interventional multi-center study, we examined and efficacy electrical in 30 patients with electrodes bilaterally implanted anterior limb internal capsule. Safety, efficacy, functionality assessments...
Abstract Although the etiology of obsessive–compulsive disorder (OCD) is largely unknown, it accepted that OCD a complex disorder. There known bi-directional interaction between gut microbiome and brain activity. Several authors have reported associations changes in microbiota neuropsychiatric disorders, including depression or autism. Furthermore, pediatric-onset OCD-related syndrome occurs after streptococcal infection, which might indicate exposure to certain microbes could be involved...
Background: Environmental stressors are considered to play an important role in the triggering of mental disorders such as obsessive–compulsive disorder (OCD). Although there is extensive literature on traumatic life events, little known about nontraumatic but nonetheless stressful events (SLEs) OCD. The aim this study was establish whether OCD preceded by SLE presents a different clinical pattern compared non-SLE-preceded Methods: We interviewed 412 patients assess both SLEs at onset and...
<h3>Background:</h3> Sensory phenomena (SP) are uncomfortable feelings, including bodily sensations, sense of inner tension, "just-right" perceptions, feelings incompleteness, or "urge-only" phenomena, which have been described to precede, trigger accompany repetitive behaviours in individuals with obsessive–compulsive disorder (OCD). also observed tic disorders, and previous research suggests that sensorimotor cortex abnormalities underpin the presence SP such patients. However, our...
Cognitive behavioural therapy (CBT), including exposure and ritual prevention, is a first-line treatment for obsessive-compulsive disorder (OCD), but few reliable predictors of CBT outcome have been identified. Based on research in animal models, we hypothesized that individual differences basolateral amygdala-ventromedial prefrontal cortex (BLA-vmPFC) communication would predict patients with OCD.We investigated whether BLA-vmPFC resting-state functional connectivity (rs-fc) predicts OCD....
Abstract Common single-nucleotide polymorphisms (SNPs) account for a large proportion of the heritability obsessive-compulsive disorder (OCD). Co-ocurrence OCD and schizophrenia is commoner than expected based on their respective prevalences, complicating clinical management patients. This study addresses two main objectives: to identify particular genes associated with by SNP-based gene-based tests; test existence polygenic risk shared schizophrenia. The primary analysis was an exon-focused...
White matter pathways, typically studied with diffusion tensor imaging (DTI), have been implicated in the neurobiology of obsessive-compulsive disorder (OCD). However, due to limited sample sizes and predominance single-site studies, generalizability OCD classification based on white estimates remains unclear. Here, we tested accuracy using largest DTI dataset date, involving 1336 adult participants (690 patients 646 healthy controls) 317 pediatric (175 142 from 18 international sites within...
<h3>Background:</h3> Recent data from neuroimaging, genetic and clinical trials animal models suggest a role for altered glutamatergic neurotransmission in the pathogenesis of obsessive–compulsive disorder (OCD). The aim this study was to investigate whether variants <i>GRIN2B</i> gene, gene encoding NR2 subunit <i>N</i>-methyl-d-aspartate (NMDA) glutamate receptor, may contribute susceptibility OCD or different subphenotypes. <h3>Methods:</h3> Between 2003 2008, we performed case–control...
Background The size of particular sub-regions within the ventromedial prefrontal cortex (vmPFC) has been associated with fear extinction in humans. Exposure therapy is a form learning widely used treatment obsessive-compulsive disorder (OCD). Here we investigated relationship between morphometric measurements different vmPFC and exposure outcome OCD. Method A total 74 OCD patients 86 healthy controls underwent magnetic resonance imaging (MRI). Cortical thickness volumetric were obtained for...
Obsessive-compulsive disorder (OCD) is a clinically heterogeneous condition. Although structural brain alterations have been consistently reported in OCD, their interaction with particular clinical subtypes deserves further examination. Among other approaches, two-group classification patients autogenous and reactive obsessions has proposed. The purpose of the present study was to assess, by means voxel-based morphometry analysis, putative correlates this scheme OCD patients. Ninety-five 95...
Sleep disturbances have been reported in obsessive-compulsive disorder (OCD) patients, with heterogeneous results. The aim of our study was to assess sleep function OCD and investigate the relationship between severity (OC) symptoms, depressive symptoms trait anxiety.Sleep quality measured 61 patients 100 healthy controls (HCs) using Pittsburgh Quality Index (PSQI). Multiple linear regression conducted explore association psychopathological measures; a mediation analysis also performed.OCD...
Memory deficits have been reported in several neuropsychological studies of obsessive-compulsive disorder (OCD). Dysfunction nonverbal memory has consistently reported, whereas findings on verbal are more heterogeneous. The authors studied 50 patients with OCD who were matched for sex, age, educational level, and hand dominance healthy controls (HC). Cognitive performance both groups was assessed tasks, clinical variables also the patient group. Patients showed a pattern cognitive...