A5061153579- Obsessive-Compulsive Spectrum Disorders
- Eating Disorders and Behaviors
- Autism Spectrum Disorder Research
- Functional Brain Connectivity Studies
- Attention Deficit Hyperactivity Disorder
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neural and Behavioral Psychology Studies
- Maternal Mental Health During Pregnancy and Postpartum
- Body Image and Dysmorphia Studies
- Mental Health Research Topics
- Advanced Neuroimaging Techniques and Applications
- COVID-19 Impact on Reproduction
- Child and Adolescent Psychosocial and Emotional Development
- Behavioral Health and Interventions
- Neurotransmitter Receptor Influence on Behavior
- Impact of Technology on Adolescents
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Psychosomatic Disorders and Their Treatments
- EEG and Brain-Computer Interfaces
- Neonatal and fetal brain pathology
- Health disparities and outcomes
- Child Nutrition and Feeding Issues
- Stress Responses and Cortisol
- Spatial Cognition and Navigation
Columbia University Irving Medical Center
2016-2025
New York State Psychiatric Institute
2014-2024
Columbia University
2015-2024
New York Psychoanalytic Society and Institute
2013-2024
University Medical Center
2022
University Hospital and Clinics
2022
King's College London
2020
Amsterdam UMC Location Vrije Universiteit Amsterdam
2019
Sunovion (United States)
2019
University of California, San Diego
2018
The purpose of this study was to examine neural activity and connectivity within cortico-striato-thalamo-cortical circuits reveal circuit-based mechanisms that govern tic generation in Tourette's syndrome.Functional magnetic resonance imaging data were acquired from 13 individuals with syndrome 21 healthy comparison subjects during spontaneous or simulated tics. Independent component analysis hierarchical partner matching used isolate functionally distinct regions circuits. Granger causality...
Associations between in utero exposure to maternal SARS-CoV-2 infection and neurodevelopment are speculated, but currently unknown.To examine the associations during pregnancy, being born COVID-19 pandemic regardless of status, at age 6 months.A cohort infants exposed pregnancy unexposed controls was enrolled Mother Baby Outcomes Initiative Columbia University Irving Medical Center New York City. All women who delivered with a were approached. Women approached based on similar gestational...
Objective: The authors examined the effect of psychostimulants on brain activity in children and adolescents with ADHD performing Stroop Color Word Test. Method: acquired 52 functional MRI scans 16 youths who were known responders to stimulant medication 20 healthy comparison youths. Participants scanned off a counterbalanced design, subjects once without medication. Results: Stimulant significantly improved suppression default-mode ventral anterior cingulate cortex group. When medication,...
We used functional magnetic resonance imaging (fMRI) to investigate the neural correlates of self-regulatory control across development in healthy individuals performing Stroop interference task. Proper performance task requires engagement inhibit an automatized response (reading) favor another, less automatic (color naming). Functional MRI scans were acquired from a sample 70 ranging age 7 57 years. measured task-related regional signal changes entire cerebrum and conducted correlation...
<h3>Context</h3> Disturbances in neural systems that mediate voluntary self-regulatory processes may contribute to bulimia nervosa (BN) by releasing feeding behaviors from regulatory control. <h3>Objective</h3> To study the functional activity circuits subserve control women with BN. <h3>Design</h3> We compared magnetic resonance imaging blood oxygenation level–dependent responses patients BN healthy controls during performance of Simon Spatial Incompatibility task. <h3>Setting</h3>...
Abstract Cortico‐striato‐thalamo‐cortical (CSTC) loops project from the cortex to striatum, then striatum thalamus via globus pallidus, and finally back again. These have been implicated in Obsessive‐Compulsive Disorder (OCD) with particular focus on limbic CSTC loop, which encompasses orbitofrontal anterior cingulate cortices, as well ventral striatum. Resting state functional‐connectivity MRI (rs‐fcMRI) studies, examine temporal correlations neural activity across brain regions at rest,...
The authors examined functional activity in the frontostriatal systems that mediate self-regulatory capacities and conflict resolution adolescents with bulimia nervosa.Functional magnetic resonance imaging was used to compare blood-oxygen-level-dependent response 18 female nervosa healthy age-matched subjects during performance on a Simon spatial incompatibility task. Bayesian analyses were two groups patterns of brain activation correct responses stimuli explore effects antecedent stimulus...
Objective: Brain imaging communities focusing on different diseases increasingly start collaborating and pooling data to perform well-powered meta- mega-analyses. Some methodologists claim that a one-stage individual-participant mega-analysis can be superior two-stage aggregated meta-analysis, since more detailed computations performed in mega-analysis. Before definitive conclusions regarding the performance of either method drawn, it is necessary critically evaluate methodology of, results...
Brain structural covariance networks reflect covariation in morphology of different brain areas and are thought to common trajectories development maturation.Large-scale investigation obsessive-compulsive disorder (OCD) may provide clues the pathophysiology this neurodevelopmental disorder.Using T 1 -weighted MRI scans acquired from 1616 individuals with OCD 1463 healthy controls across 37 datasets participating ENIGMA-OCD Working Group, we calculated intra-individual (using...
Anticorrelated resting state connectivity between task-positive and task-negative networks in adults supports flexible shifting externally focused attention internal thought. Findings suggest that children show positive correlations (frontoparietal; FP) (default mode; DMN) networks. FP-DMN also associates with intellectual functioning across the lifespan. We investigated whether healthy varied age intelligence quotient (IQ).We utilized network-based statistics (NBS) to examine functional FP...
Importance Associations between prenatal SARS-CoV-2 exposure and neurodevelopmental outcomes have substantial public health relevance. A previous study found no association infection parent-reported infant outcomes, but standardized observational assessments are needed to confirm this finding. Objective To assess whether mild or asymptomatic maternal vs during pregnancy is associated with differences at ages 5 11 months. Design, Setting, Participants This cohort included infants of mothers...
Abstract Current knowledge about functional connectivity in obsessive-compulsive disorder (OCD) is based on small-scale studies, limiting the generalizability of results. Moreover, majority studies have focused only predefined regions or networks rather than throughout entire brain. Here, we investigated differences resting-state between OCD patients and healthy controls (HC) using mega-analysis data from 1024 1028 HC 28 independent samples ENIGMA-OCD consortium. We assessed group...
Objective: Disturbances in the maturation of neural systems that mediate self-regulatory processes may contribute to development Tourette's syndrome by releasing motor and vocal tics from regulatory control. The purpose this study was examine age correlates functional activity circuits subserve control children adults with syndrome. Method: participants were 136 adults, which included 66 patients 70 healthy comparison subjects. During performance Stroop interference task, authors compared...
The etiology of Tourette syndrome (TS) involves disturbances in the structure and function basal ganglia. ganglia mediate habit learning.To study learning persons with TS.Patients TS were compared normal controls performance on a probabilistic classification, or habit-learning task (weather prediction).University research institute.One hundred twenty-three children adults, 56 diagnosis 67 healthy control subjects.Habit was assessed by extent improvement accuracy predictions reaction times...
The authors sought to study activity in neural circuits that subserve the inhibition of a semi-involuntary motor behavior, eye blinking, children and adults with Tourette syndrome healthy comparison subjects.Functional magnetic resonance imaging was used scan 120 participants (51 69 subjects) as they either blinked normally or successfully inhibited blinking. compared blood-oxygen-level dependent signal during these two conditions across groups.Relative subjects, patients activated more...