Kerstin Jessica Plessen
A5042822649- Child and Adolescent Psychosocial and Emotional Development
- Autism Spectrum Disorder Research
- Obsessive-Compulsive Spectrum Disorders
- Attention Deficit Hyperactivity Disorder
- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Adolescent and Pediatric Healthcare
- Functional Brain Connectivity Studies
- Eating Disorders and Behaviors
- Maternal Mental Health During Pregnancy and Postpartum
- Child Nutrition and Feeding Issues
- Genetic Associations and Epidemiology
- Neural and Behavioral Psychology Studies
- Behavioral and Psychological Studies
- Child and Adolescent Health
- Psychoanalysis and Psychopathology Research
- Early Childhood Education and Development
- Family Caregiving in Mental Illness
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Music Perception
- Genetics and Neurodevelopmental Disorders
- Diet and metabolism studies
- Health, Medicine and Society
- Fetal and Pediatric Neurological Disorders
- Family Support in Illness
University of Lausanne
2018-2025
Mental Health Services
2016-2025
Gentofte Hospital
2020-2025
Copenhagen University Hospital
2015-2025
Capital Region of Denmark
2016-2025
Lundbeck Foundation
2016-2025
Hôpital Nestlé
2025
University of Copenhagen
2015-2024
University Hospital of Lausanne
2019-2024
Yale University
2024
To develop a European guideline on pharmacologic treatment of Tourette syndrome (TS) the available literature was thoroughly screened and extensively discussed by working group Society for Study (ESSTS). Although there are many more studies pharmacotherapy TS than behavioral options, only limited number meets rigorous quality criteria. Therefore, we have devised two-stage approach. First, present highest level evidence reporting findings existing Cochrane reviews in this field. Subsequently,...
Objective: Neuroimaging studies show structural alterations of various brain regions in children and adults with attention deficit hyperactivity disorder (ADHD), although nonreplications are frequent. The authors sought to identify cortical characteristics related ADHD using large-scale studies. Methods: Cortical thickness surface area (based on the Desikan–Killiany atlas) were compared between case subjects (N=2,246) control (N=1,934) for children, adolescents, separately ENIGMA-ADHD, a...
<h3>Context</h3> Limbic structures are implicated in the genesis of attention-deficit/hyperactivity disorder (ADHD) by presence mood and cognitive disturbances affected individuals elevated rates disorders family members probands with ADHD. <h3>Objective</h3> To study morphology hippocampus amygdala children <h3>Design</h3> A cross-sectional case-control using anatomical magnetic resonance imaging. <h3>Settings</h3> University research institute. <h3>Patients</h3> One hundred fourteen aged 6...
Neurodevelopmental brain disorders such as schizophrenia, autism and attention deficit hyperactivity disorder are complex with heterogeneous etiologies. Schizophrenia difficult to treat often cause major individual suffering largely owing our limited understanding of the disease biology. Thus biological pathogenesis needs be substantiated enable development more targeted treatment options improved efficacy. Insights into pre-morbid dynamics, morbid condition underlying mechanisms may come...
Objective: The authors examined the effect of psychostimulants on brain activity in children and adolescents with ADHD performing Stroop Color Word Test. Method: acquired 52 functional MRI scans 16 youths who were known responders to stimulant medication 20 healthy comparison youths. Participants scanned off a counterbalanced design, subjects once without medication. Results: Stimulant significantly improved suppression default-mode ventral anterior cingulate cortex group. When medication,...
Background Children with Tourette syndrome generally experience improvement of tics by age 18 years, but psychosocial and comorbidity outcomes at this are unclear. Aims To compare lifetime rates in older adolescents controls. We hypothesised a priori that individuals would have lower Children's Global Assessment Scale (CGAS) scores. Method A total 65 syndrome, identified childhood, matched community controls without tic or obsessive–compulsive disorder (OCD) symptoms were assessed around...
Highlights•Recurrent de novo variants identify a new high-confidence TD risk gene: CELSR3•Genes involved in cell polarity are more likely to be disrupted by variants•De sequence may carry simplex families, female probands•De CNVs occur 2 3 times often probands than matched controlsSummaryWe previously established the contribution of damaging Tourette disorder (TD) through whole-exome sequencing 511 trios. Here, we an additional 291 trios and analyze combined set 802 We observe...
<h3>Importance</h3> Several mental disorders have consistently been found to be associated with decreased life expectancy, but little is known about whether this also the case for obsessive-compulsive disorder (OCD). <h3>Objective</h3> To determine persons who receive a diagnosis of OCD are at increased risk death. <h3>Design, Setting, and Participants</h3> Using data from Danish registers, we conducted nationwide prospective cohort study 30 million person-years follow-up. The were collected...
We assessed the correlations of age, sex, and cognitive performance with measures asymmetry in cortical thickness on high-resolution MRIs 215 healthy human children adults, 7–59 years age. A left > right mantle was present throughout entire lateral, dorsal, mesial surfaces frontal lobe, extending into primary sensory, superior parietal, anterior temporal cortices. mesial, dorsal posterior temporal, occipital cortices, as well inferior surface brain. An exaggerated detected females brain...
Some studies have suggested alterations of structural brain asymmetry in attention-deficit/hyperactivity disorder (ADHD), but findings been contradictory and based on small samples. Here, we performed the largest ever analysis left-right ADHD, using 39 datasets ENIGMA consortium.
OBJECTIVE: The corpus callosum is the major commissure connecting cerebral hemispheres. Prior evidence suggests involvement of in pathophysiology Tourette's disorder. authors assessed size and anatomical connectivity across hemispheres persons with METHOD: was determined on true midsagittal slices reformatted, high-resolution magnetic resonance imaging scans compared groups a cross-sectional case-control study 158 subjects disorder 121 healthy comparison subjects, ages 5–65 years. RESULTS:...
Background: Brain imaging studies have revealed anatomical anomalies in the brains of individuals with Tourette syndrome (TS). Prefrontal regions been found to be larger and corpus callosum (CC) area smaller children young adults TS compared healthy control subjects, these features understood reflect neural plasticity that helps attenuate severity tics. Method: CC white matter connectivity, as measured by Fractional Anisotropy (FA) index from diffusion tensor images, was assessed 20...
Severe mental illnesses like schizophrenia and bipolar disorder are known to be diseases that some extent, but not entirely can understood genetically. The dominating hypothesis is these disorders should in a neurodevelopmental perspective where genes environment as well gene-environment-interactions contribute the risk of developing disease. We aim analyse influences genetic environmental factors population 520 7-year-old children with either 0, 1 or 2 parents diagnosed spectrum psychosis...
Children at familial high risk of schizophrenia spectrum disorders (FHR-SZ) or bipolar disorder (FHR-BP) exhibit neurocognitive impairments. Large studies neurocognition in young children the same age are important to differentiate pathophysiology and developmental trajectory these 2 groups.To characterize functions 7-year-old with FHR-SZ FHR-BP a control population.This multisite population-based cohort study collected data from January 1, 2013, 31, 2016, first wave Danish High Risk...
This study aimed to compare the psychopathological profiles of children at familial high risk schizophrenia spectrum psychosis (FHR-SZ) or bipolar disorder (FHR-BP) with population-based controls. We used Danish nationwide registers retrieve a cohort 522 seven-year-old parents (N=202), (N=120) none these disorders (N=200). Psychopathology was assessed by reports from multiple informants, including children, and teachers. Lifetime DSM-IV diagnoses were ascertained blinded raters through...
Abstract Objective Studies on parental socioeconomic status (SES) and family risk factors for eating disorders (EDs) have yielded inconsistent results; however, several studies identified high educational attainment as a factor. The aim was to evaluate associations of SES composition with anorexia nervosa (AN), bulimia (BN), not otherwise specified (EDNOS) in the offspring, adjusting age mental health. Methods cohort included women born Denmark between January 1, 1989 December 31, 2010,...