Lawrence W. Brown
A5056700192- Obsessive-Compulsive Spectrum Disorders
- Autism Spectrum Disorder Research
- Childhood Cancer Survivors' Quality of Life
- Adolescent and Pediatric Healthcare
- Botulinum Toxin and Related Neurological Disorders
- Epilepsy research and treatment
- Genetics and Neurodevelopmental Disorders
- Williams Syndrome Research
- Child Nutrition and Feeding Issues
- Sleep and Wakefulness Research
- Child and Adolescent Health
- Neuroscience of respiration and sleep
- Traumatic Brain Injury and Neurovascular Disturbances
- Bacterial Infections and Vaccines
- Space Satellite Systems and Control
- Genomic variations and chromosomal abnormalities
- Hereditary Neurological Disorders
- Neonatal Respiratory Health Research
- Sleep and related disorders
- Neonatal and fetal brain pathology
- Neurological disorders and treatments
- Genetic Associations and Epidemiology
- Maritime Navigation and Safety
- Astro and Planetary Science
- Lignin and Wood Chemistry
Children's Hospital of Philadelphia
2013-2023
Neuroscience Research Australia
2021
University of Pennsylvania
1996-2020
Child Neurology Society
2020
Stanley Foundation
2019
Massachusetts General Hospital
2019
Broad Institute
2019
University of Michigan
2018
Sheffield Teaching Hospitals NHS Foundation Trust
2013-2016
Texas Children's Hospital
2016
<h3>Objective:</h3> To assess efficacy and safety of once-daily 8 or 12 mg perampanel, a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor antagonist, when added to concomitant antiepileptic drugs (AEDs) in the treatment drug-resistant partial-onset seizures. <h3>Methods:</h3> This was multicenter, double-blind, placebo-controlled trial (ClinicalTrials.gov identifier: NCT00699972). Patients (≥12 years, with ongoing seizures despite 1–3 AEDs) were randomized...
Highlights•Recurrent de novo variants identify a new high-confidence TD risk gene: CELSR3•Genes involved in cell polarity are more likely to be disrupted by variants•De sequence may carry simplex families, female probands•De CNVs occur 2 3 times often probands than matched controlsSummaryWe previously established the contribution of damaging Tourette disorder (TD) through whole-exome sequencing 511 trios. Here, we an additional 291 trios and analyze combined set 802 We observe...
The child neurologist has a critical role in planning and coordinating the successful transition from pediatric to adult health care system for youth with neurologic conditions. Leadership appropriately youth's coordination among care, educational, vocational, community services providers may assist preventing gaps delayed entry into system, and/or crises their adolescent patients. Youth whose conditions result cognitive or physical disability families need additional support during this...
A series of studies were conducted to investigate pediatricians' training, knowledge, and practices regarding sleep disorders in children adolescents.Study 1, a national survey 156 pediatric residency programs, found that pediatricians receive mean 4.8 hours instruction on disorders, although the mode median is 0 hours. In study 2, 88 completing questionnaire concerning general knowledge about adolescents received score 71.8% (range, 40% 93%). Pediatricians appear know most developmental...
Baylisascaris procyonis, the ascarid of raccoons, causes a characteristic, rapidly fatal eosinophilic meningoencephalitis with ocular involvement in many naturally and experimentally infected aberrant hosts, including monkeys. Warnings that humans are potentially susceptible to devastating infection have been issued, but an instance has not recognized. This report describes boy who died from meningoencephalitis, which mimicked B. procyonis The causative agent was identified during life....
Forty-four cases of botulism occurred in infants Southeastern Pennsylvania between 1976 and 1983. Forty-three were caused by Clostridium botulinum type B. Progressive weakness necessitated ventilatory support 39 infants. Complications during hospitalization included otitis media 13 patients aspiration pneumonia 11. Eight developed the syndrome inappropriate secretion antidiuretic hormone two adult respiratory distress syndrome. One infant died progressive bradycardia despite adequate control...
Abstract Tourette syndrome (TS) is a neuropsychiatric disorder of complex genetic architecture involving multiple interacting genes. Here, we sought to elucidate the pathways that underlie neurobiology through genome-wide analysis. We analyzed genotypic data 3581 individuals with TS and 7682 ancestry-matched controls investigated associations sets genes are expressed in particular cell types operate specific neuronal glial functions. employed self-contained, set-based association method...
Abstract Autism spectrum disorder (ASD), Tourette syndrome (TS), and attention-deficit/hyperactivity (ADHD) display strong male sex bias, due to a combination of genetic biological factors, as well selective ascertainment. While the hemizygous nature chromosome X (Chr X) in males has long been postulated key point “male vulnerability”, rare variation on this not systematically characterized large-scale whole exome sequencing studies “idiopathic” ASD, TS, ADHD. Here, we take advantage...
view Abstract Citations (43) References (13) Co-Reads Similar Papers Volume Content Graphics Metrics Export Citation NASA/ADS An extensive galactic search for conformer II Glycine. Snyder, L. E. ; Hollis, J. M. Suenram, R. D. Lovas, F. Brown, W. Buhl, The most reported to date glycine, a higher energy form of the simplest amino acid has been conducted. utilized four glycine transitions at centimeter wavelengths and 21 millimeter observe 18 molecular sources one comet. No lines were detected,...
Abstract A continuous biomass fractionation process for producing ethanol and low‐molecular‐weight lignin was developed, its economic feasibility evaluated. The two‐stage fractionates into three streams: a solid cellulose stream two liquid streams containing mostly hemicellulosic sugars lignin, respectively. Process optimization conducted using corn stover as feedstock in pilot‐scale unit, with the goals of efficient hemicellulose hydrolysis countercurrent first cocurrent second stage,...