A5021099852- EEG and Brain-Computer Interfaces
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Neonatal and fetal brain pathology
- Functional Brain Connectivity Studies
- Blind Source Separation Techniques
- ECG Monitoring and Analysis
- Cardiovascular Syncope and Autonomic Disorders
- Transcranial Magnetic Stimulation Studies
- Cannabis and Cannabinoid Research
- Neural dynamics and brain function
- Drug Transport and Resistance Mechanisms
- Neurological disorders and treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Phonocardiography and Auscultation Techniques
- Neuroscience and Neural Engineering
- Neural and Behavioral Psychology Studies
- Psychosomatic Disorders and Their Treatments
- Metabolism and Genetic Disorders
- Reliability and Agreement in Measurement
- Non-Invasive Vital Sign Monitoring
- Neural Networks and Applications
- Autoimmune Neurological Disorders and Treatments
- Advanced Neuroimaging Techniques and Applications
Medical University of South Carolina
2016-2025
Ralph H. Johnson VA Medical Center
2016-2025
Massachusetts General Hospital
2016-2023
Harvard University
2016-2023
University of Miami
2022
Columbia University
2022
Stanford University
2022
New York University
2022
Hospices Civils de Lyon
2022
Hôpital Femme Mère Enfant
2022
<h3>Objective:</h3> To assess efficacy and safety of once-daily 8 or 12 mg perampanel, a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor antagonist, when added to concomitant antiepileptic drugs (AEDs) in the treatment drug-resistant partial-onset seizures. <h3>Methods:</h3> This was multicenter, double-blind, placebo-controlled trial (ClinicalTrials.gov identifier: NCT00699972). Patients (≥12 years, with ongoing seizures despite 1–3 AEDs) were randomized...
The aims of this study were to determine the etiology, clinical features, and predictors outcome new-onset refractory status epilepticus. Retrospective review patients with epilepticus without etiology identified within 48 hours admission between January 1, 2008, December 31, 2013, in 13 academic medical centers. primary measure was poor functional at discharge (defined as a score >3 on modified Rankin Scale). Of 130 cases, 67 (52%) remained cryptogenic. most common etiologies autoimmune...
<h3>Objective</h3> To prospectively evaluate safety and efficacy of brain-responsive neurostimulation in adults with medically intractable focal onset seizures (FOS) over 9 years. <h3>Methods</h3> Adults treated 2-year feasibility or randomized controlled trials were enrolled a long-term prospective open label trial (LTT) to assess safety, efficacy, quality life (QOL) an additional 7 Safety was assessed as adverse events (AEs), median percent change seizure frequency responder rate, QOL the...
Although no single best method exists for recording EEGs under all circumstances, the following standards are considered minimum usual clinical of in age groups except very young (see also Guideline 5: Minimum Technical Standards Pediatric Electroencephalography. Sections where modifications recommended delineated by ^for neonates and *for older children). This document discusses requirements; these requirements alone does not ensure a satisfactory test. Each laboratory should strive...
Abstract Objective During the development of cenobamate, an antiseizure medication (ASM) for focal seizures, three cases drug reaction with eosinophilia and systemic symptoms (DRESS) occurred. To mitigate rate DRESS, a start‐low, go‐slow approach was studied in ongoing, open‐label, multicenter study. Also examined were long‐term safety cenobamate method managing pharmacokinetic interaction between 2C19 inhibitor, concomitant phenytoin or phenobarbital. Methods Patients 18‐70 years old...
Interictal epileptiform discharges (IEDs) in electroencephalograms (EEGs) are a biomarker of epilepsy, seizure risk, and clinical decline. However, there is scarcity experts qualified to interpret EEG results. Prior attempts automate IED detection have been limited by small samples not demonstrated expert-level performance. There need for validated automated method detect IEDs with reliability.To develop validate computer algorithm the ability identify as reliably classify an recording...
Medial temporal epilepsy (MTLE) is associated with extrahippocampal brain atrophy. The mechanisms underlying damage in MTLE are unknown. Seizures may lead to neuronal damage, but another possible explanation deafferentation from loss of hippocampal connections. This study aimed investigate the relationship between and atrophy MTLE.Three different MRI studies were performed involving 23 patients unilateral (8 left 15 right) 34 healthy controls: (1) voxel-based morphometry (VBM), (2) diffusion...
Summary Objective Patients with Lennox‐Gastaut syndrome ( LGS ) who completed 1 of 2 randomized, double‐blind, placebo‐controlled trials add‐on cannabidiol CBD GWPCARE 3, NCT 02224560 or 4, 02224690) were invited to enroll in an open‐label extension OLE study evaluating the long‐term safety and efficacy 5, 02224573). Herein we present interim analysis safety, efficacy, patient‐reported outcomes from this trial. Methods received a pharmaceutical formulation highly purified oral solution...
<h3>Importance</h3> The validity of using electroencephalograms (EEGs) to diagnose epilepsy requires reliable detection interictal epileptiform discharges (IEDs). Prior interrater reliability (IRR) studies are limited by small samples and selection bias. <h3>Objective</h3> To assess the experts in detecting IEDs routine EEGs. <h3>Design, Setting, Participants</h3> This prospective analysis conducted 2 phases included as participants physicians with at least 1 year subspecialty training...
<h3>Objective:</h3> To evaluate the sensitivity of quantitative EEG (QEEG) for electrographic seizure identification in intensive care unit (ICU). <h3>Methods:</h3> Six-hour epochs chosen from 15 patients underwent transformation into QEEG displays. Each epoch was reviewed 3 formats: raw EEG, + raw, and QEEG-only. Epochs were also analyzed by a proprietary detection algorithm. Nine neurophysiologists EEGs to identify seizures serve as gold standard. other with experience evaluated formats,...
Summary Objective A prospective multicenter phase III trial was undertaken to evaluate the performance and tolerability in epilepsy monitoring unit ( EMU ) of an investigational wearable surface electromyographic sEMG system for detection generalized tonic–clonic seizures GTCSs ). Methods One hundred ninety‐nine patients with a history who were admitted 11 level IV centers clinically indicated video‐electroencephalographic also received device that worn on arm over biceps muscle. All...
Summary Objective Lennox–Gastaut syndrome (LGS) is an epileptic encephalopathy that often treatment resistant. Efficacy and safety of add‐on cannabidiol (CBD) to treat seizures associated with LGS was demonstrated in two randomized controlled trials (RCTs). Patients who completed the RCTs were invited enroll this long‐term open‐label extension (OLE) trial, GWPCARE5 (NCT02224573). We present final analysis efficacy outcomes from GWPCARE5. Methods received plant‐derived highly purified CBD...
Visual evaluation of electroencephalogram (EEG) for Interictal Epileptiform Discharges (IEDs) as distinctive biomarkers epilepsy has various limitations, including time-consuming reviews, steep learning curves, interobserver variability, and the need specialized experts. The development an automated IED detector is necessary to provide a faster reliable diagnosis epilepsy. In this paper, we propose based on Convolutional Neural Networks (CNNs). We have evaluated proposed sizable database 554...
Abstract Objective Add‐on cannabidiol (CBD) reduced seizures associated with Dravet syndrome (DS) in two randomized, double‐blind, placebo‐controlled trials: GWPCARE1 Part B (NCT02091375) and GWPCARE2 (NCT02224703). Patients who completed A (NCT02091206) or B, GWPCARE2, were enrolled a long‐term open‐label extension trial, GWPCARE5 (NCT02224573). We present an interim analysis of the safety, efficacy, patient‐reported outcomes from GWPCARE5. Methods received pharmaceutical formulation highly...
Seizures (SZs) and other SZ-like patterns of brain activity can harm the contribute to in-hospital death, particularly when prolonged. However, experts qualified interpret EEG data are scarce. Prior attempts automate this task have been limited by small or inadequately labeled samples not convincingly demonstrated generalizable expert-level performance. There exists a critical unmet need for an automated method classify SZs events with reliability. This study was conducted develop validate...
<b>Background:</b> Structural neuroimaging studies have consistently shown a pattern of extra-hippocampal atrophy in patients with left and right drug-refractory medial temporal lobe epilepsy (MTLE). However, it is not yet completely understood how related to hippocampal atrophy. Moreover, MTLE often exhibit more intense cognitive impairment, subtle brain asymmetries been reported versus but explored controlled study. <b>Objectives:</b> To investigate the association between MTLE, effect...
Mood, anxiety disorders, and suicidality are more frequent in people with epilepsy than the general population. Yet, their prevalence types of mood disorders associated at time diagnosis not established. We sought to answer these questions patients newly diagnosed focal assess association suicidal ideation attempts.The data were derived from Human Epilepsy Project study. A total 347 consecutive adults aged 18-60 years enrolled within 4 months starting treatment. The identified Mini...