Elizabeth E. Gerard
A5045425222- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Pregnancy and Medication Impact
- EEG and Brain-Computer Interfaces
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroscience and Neuropharmacology Research
- Maternal Mental Health During Pregnancy and Postpartum
- Neonatal and fetal brain pathology
- Genomics and Rare Diseases
- Infectious Encephalopathies and Encephalitis
- Genetics and Neurodevelopmental Disorders
- Electrolyte and hormonal disorders
- Pharmaceutical studies and practices
- Metabolism and Genetic Disorders
- Ion channel regulation and function
- Hemodynamic Monitoring and Therapy
- Neurological Complications and Syndromes
- Pregnancy and preeclampsia studies
- Folate and B Vitamins Research
- Cerebrospinal fluid and hydrocephalus
- Neuroscience of respiration and sleep
- Vascular Malformations Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Neurological disorders and treatments
- Reproductive Health and Contraception
Northwestern University
2016-2025
Columbia University
2003-2024
Stanford University
2019-2024
Emory University
2019-2024
University of Southern California
2019-2024
University of Minnesota
2019-2024
McGill University
2024
Vanderbilt University Medical Center
2024
Northwestern Memorial Hospital
2017-2024
Munson Medical Center
2024
INTRODUCTION In the early 2000s, a subcommittee of American Clinical Neurophysiology Society (ACNS) set out to “standardize terminology periodic and rhythmic EEG patterns in critically ill aid future research involving such patterns.” The initial proposed was published 2005.1 This presented at many meetings on several continents, subjected multiple rounds testing interrater reliability, underwent revisions, then as an ACNS guideline 2013.2 Interrater agreement 2012 version (published 2013)...
Critical Care Continuous EEG (CCEEG) is a common procedure to monitor brain function in patients with altered mental status intensive care units. There significant variability patient populations undergoing CCEEG and technical specifications for performance.The Task Force of the American Clinical Neurophysiology Society developed expert consensus recommendations on use critically ill adults children.The panel recommends diagnosis nonconvulsive seizures, epilepticus, other paroxysmal events,...
The aims of this study were to determine the etiology, clinical features, and predictors outcome new-onset refractory status epilepticus. Retrospective review patients with epilepticus without etiology identified within 48 hours admission between January 1, 2008, December 31, 2013, in 13 academic medical centers. primary measure was poor functional at discharge (defined as a score >3 on modified Rankin Scale). Of 130 cases, 67 (52%) remained cryptogenic. most common etiologies autoimmune...
Critical Care Continuous EEG (CCEEG) is a common procedure to monitor brain function in patients with altered mental status intensive care units. There significant variability patient populations undergoing CCEEG and technical specifications for performance.The Task Force of the American Clinical Neurophysiology Society developed expert consensus recommendations on use critically ill adults children.The panel describes qualifications responsibilities personnel including neurodiagnostic...
This practice guideline provides updated evidence-based conclusions and recommendations regarding the effects of antiseizure medications (ASMs) folic acid supplementation on prevalence major congenital malformations (MCMs), adverse perinatal outcomes, neurodevelopmental outcomes in children born to people with epilepsy childbearing potential (PWECP). A multidisciplinary panel conducted a systematic review developed following process outlined 2017 edition American Academy Neurology Clinical...
Continuous EEG monitoring (cEEG) of critically ill adults is being used with increasing frequency, and practice guidelines on indications for cEEG have recently been published. However, data describing the current in limited. We aimed to describe United States.A survey assessing procedures was sent one intensivist neurophysiologist responsible intensive care unit (ICU) at 151 institutions States. At some only physician could be identified.One hundred thirty-seven physicians from 97 completed...
There is limited information on infant drug exposure via breastfeeding by mothers who are receiving antiepileptic therapy.To provide direct, objective through breast milk.This prospective cohort study was conducted between December 2012 to October 2016, with follow-up in children until 6 years of age at 20 sites across the United States. Data were collected an observational multicenter investigation (Maternal Outcomes and Neurodevelopmental Effects Antiepileptic Drugs [MONEAD]) outcomes...
<h3>Objective:</h3> To evaluate the sensitivity of quantitative EEG (QEEG) for electrographic seizure identification in intensive care unit (ICU). <h3>Methods:</h3> Six-hour epochs chosen from 15 patients underwent transformation into QEEG displays. Each epoch was reviewed 3 formats: raw EEG, + raw, and QEEG-only. Epochs were also analyzed by a proprietary detection algorithm. Nine neurophysiologists EEGs to identify seizures serve as gold standard. other with experience evaluated formats,...
Among women with epilepsy, studies regarding changes in seizure frequency during pregnancy have been limited by the lack of an appropriate nonpregnant comparator group to provide data on natural course both groups.
During pregnancy in women with epilepsy, lower blood concentrations of antiseizure medications can have adverse clinical consequences.
Abstract Febrile infection‐related epilepsy syndrome (FIRES) is a subset of new onset refractory status epilepticus (NORSE) that involves febrile infection prior to the epilepticus. It unclear whether FIRES and non‐FIRES NORSE are distinct conditions. Here, we compare 34 patients with 30 for demographics, clinical features, neuroimaging, outcomes. Because were younger than (median = 28 vs. 48 years old, p .048) more likely cryptogenic (odds ratio 6.89), next ran regression analysis using age...
Emerging evidence suggests that immune dysregulation plays a pivotal role in triggering cryptogenic new-onset refractory status epilepticus (c-NORSE), prompting consensus on early initiation of immunotherapy. However, despite similar timing administration, responses to immunotherapies have been varied and unpredictable, suggesting the presence heterogeneous underlying mechanisms. The aim this study was identify distinct inflammatory response subtypes patients with c-NORSE by analyzing their...
ABSTRACT BACKGROUND AND PURPOSE Evidence from animal models and examination of human epilepsy surgery specimens indicates that inflammation plays an important role in epilepsy. Positron emission tomography (PET) using [C11]PK11195, a marker activated microglia, provides means to visualize neuroinflammation vivo humans. We hypothesize patients with active epilepsy, [C11]PK11195 PET (PK‐PET) may be able identify areas focally increased corresponding the seizure onset zone. METHODS A young...
OBJECTIVE Sudden unexpected death in epilepsy (SUDEP) is the leading cause of for patients with refractory epilepsy, and there increasing evidence a centrally mediated respiratory depression as pathophysiological mechanism. The brain regions responsible seizure’s inducing are unclear—the nuclei brainstem thought to be involved, but involvement forebrain structures not yet understood. aim this study was analyze intracranial EEGs combination results monitoring investigate relationship between...
<h3>Importance</h3> The neurodevelopmental risks of fetal exposure are uncertain for many antiseizure medications (ASMs). <h3>Objective</h3> To compare children at 2 years age who were born to women with epilepsy (WWE) vs healthy and assess the association maximum ASM in third trimester subsequent cognitive abilities among WWE. <h3>Design, Setting, Participants</h3> Maternal Outcomes Neurodevelopmental Effects Antiepileptic Drugs (MONEAD) study is a prospective, observational, multicenter...
Importance Many patients with focal epilepsy experience seizures despite treatment currently available antiseizure medications (ASMs) and may benefit from novel therapeutics. Objective To evaluate the efficacy safety of XEN1101, a small-molecule selective Kv7.2/Kv7.3 potassium channel opener, in focal-onset (FOSs). Design, Setting, Participants This phase 2b, randomized, double-blind, placebo-controlled, parallel-group, dose-ranging adjunctive trial investigated XEN1101 over an 8-week period...
Abstract In response to the evolving treatment landscape for new‐onset refractory status epilepticus (NORSE) and publication of consensus recommendations in 2022, we conducted a comparative analysis NORSE management over time. Seventy‐seven patients were enrolled by 32 centers, from July 2016 August 2023, NORSE/FIRES biorepository at Yale. Immunotherapy was administered 88% after median 3 days, with 52% receiving second‐line immunotherapy 12 days (anakinra 29%, rituximab 25%, tocilizumab...
Objective The optimal treatment of nonconvulsive seizures in critically ill patients is uncertain. We evaluated the comparative effectiveness antiseizure drugs lacosamide (LCM) and fosphenytoin (fPHT) this population. Methods TRENdS (Treatment Recurrent Electrographic Nonconvulsive Seizures) study was a noninferiority, prospective, multicenter, randomized trial diagnosed with (NCSs) by continuous electroencephalography (cEEG). Treatment to intravenous (IV) LCM 400mg or IV fPHT 20mg phenytoin...