A5033940986- Intensive Care Unit Cognitive Disorders
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Anesthesia and Sedative Agents
- Epilepsy research and treatment
- Neural dynamics and brain function
- Anesthesia and Neurotoxicity Research
- Neuroscience and Neural Engineering
- Traumatic Brain Injury and Neurovascular Disturbances
- Long-Term Effects of COVID-19
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Alcoholism and Thiamine Deficiency
- Neurological disorders and treatments
- Photoreceptor and optogenetics research
- Neural and Behavioral Psychology Studies
- Pregnancy and Medication Impact
- Electrochemical Analysis and Applications
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Electroconvulsive Therapy Studies
- Product Development and Customization
- Frailty in Older Adults
- Health and Medical Research Impacts
- Bipolar Disorder and Treatment
Vanderbilt University Medical Center
2019-2025
Vanderbilt University
2020-2024
Munson Medical Center
2024
Columbia University
2024
McGill University
2024
Centre for Biomedical Engineering and Physics
2022
Neurology, Inc
2022
University of Utah
2022
Monroe Carell Jr. Children's Hospital
2022
University of Pennsylvania
2015-2020
Delirium is a debilitating form of brain dysfunction frequently encountered in the intensive care unit (ICU). It associated with increased morbidity and mortality, longer lengths stay, higher hospital costs, cognitive impairment that persists long after discharge. Predisposing factors include smoking, hypertension, cardiac disease, sepsis, premorbid dementia. Precipitating respiratory failure shock, metabolic disturbances, prolonged mechanical ventilation, pain, immobility, sedatives adverse...
Abstract Why are people with focal epilepsy not continuously having seizures? Previous neuronal signalling work has implicated gamma-aminobutyric acid balance as integral to seizure generation and termination, but is a high-level distributed brain network involved in suppressing Recent intracranial electrographic evidence suggested that seizure-onset zones have increased inward connectivity could be associated interictal suppression of activity. Accordingly, we hypothesize actively...
This practice guideline provides updated evidence-based conclusions and recommendations regarding the effects of antiseizure medications (ASMs) folic acid supplementation on prevalence major congenital malformations (MCMs), adverse perinatal outcomes, neurodevelopmental outcomes in children born to people with epilepsy childbearing potential (PWECP). A multidisciplinary panel conducted a systematic review developed following process outlined 2017 edition American Academy Neurology Clinical...
Zolpidem produces paradoxical recovery of speech, cognitive and motor functions in select subjects with severe brain injury but underlying mechanisms remain unknown. In three diverse patients known zolpidem responses we identify a distinctive pattern EEG dynamics that suggests mechanistic model. the absence zolpidem, all show strong low frequency oscillatory peak ∼6–10 Hz power spectrum most prominent over frontocentral regions high coherence (∼0.7–0.8) within between hemispheres....
Importance Sepsis is associated with long-term cognitive impairment and worse psychological functional outcomes. Potential mechanisms include intracerebral oxidative stress inflammation, yet little known about the effects of early antioxidant anti-inflammatory therapy on cognitive, psychological, outcomes in sepsis survivors. Objective To describe observed differences vitamin C, thiamine, hydrocortisone between intervention control groups Vitamin Thiamine, Steroids (VICTAS) randomized...
Objective. Implanting subdural and penetrating electrodes in the brain causes acute trauma inflammation that affect intracranial electroencephalographic (iEEG) recordings. This behavior its potential impact on clinical decision-making algorithms for implanted devices have not been assessed detail. In this study we aim to characterize temporal spatial variability of continuous, prolonged human iEEG Approach. Intracranial electroencephalography from 15 patients with drug-refractory epilepsy,...
Abstract Successful surgical treatment of drug-resistant epilepsy traditionally relies on the identification seizure onset zones (SOZs). Connectome-based analyses electrographic data from stereo electroencephalography (SEEG) may empower improved detection SOZs. Specifically, connectome-based based interictal suppression hypothesis posit that when patient is not having a seizure, SOZs are inhibited by non-SOZs through high inward connectivity and low outward connectivity. However, it clear...
<h3>Background and Objectives</h3> Functional connectivity (FC) measures can be used to differentiate epileptogenic zones (EZs) from non-EZs in patients with medically refractory epilepsy. Little work has been done evaluate the stability of stereo-EEG (SEEG) FC over time their relationship antiseizure medication (ASM) use, a critical confounder epilepsy studies. We aimed answer following questions: Are SEEG stable time? they influenced by ASMs? affected patient data collection state?...
Abstract Objective To evaluate the safety, feasibility, and efficacy of combined adrenergic blockade with propranolol clonidine in patients severe traumatic brain injury (TBI). Background Administration after TBI is common. date, no prospective trial has rigorously evaluated this common therapy for benefit. Methods This phase II, single-center, double-blinded, pilot randomized placebo-controlled included aged 16–64 years (intracranial hemorrhage Glasgow Coma Scale score ≤ 8) within 24 h ICU...
In drug-resistant temporal lobe epilepsy, automated tools for seizure onset zone (SOZ) localization that use brief interictal recordings could supplement presurgical evaluations and improve care. Thus, the authors sought to localize SOZs by training a multichannel convolutional neural network on stereoelectroencephalography (SEEG) cortico-cortical evoked potentials.
ABSTRACT Executive functions, including working memory, are typically assessed clinically with neuropsychological instruments. In contrast, computerized tasks used to test these cognitive functions in laboratory human and animal studies. Little is known of how neural activity captured by relates ability measured clinical instruments and, extension, diagnoses pathological conditions. We therefore sought determine what aspects elicited predictive performance recorded from intracranial...
This practice guideline provides updated evidence-based conclusions and recommendations regarding the effects of antiseizure medications (ASMs) folic acid supplementation on prevalence major congenital malformations (MCMs), adverse perinatal outcomes, neuro-developmental outcomes in children born to people with epilepsy childbearing potential (PWECP). A multidisciplinary panel conducted a systematic review developed following process outlined 2017 edition American Academy Neurology Clinical...
Abstract Risk-taking behaviour is a symptom of multiple neuropsychiatric disorders and often lacks effective treatments. Reward circuitry regions including the amygdala, orbitofrontal cortex, insula, anterior cingulate have been implicated in risk-taking, but electrophysiological activity predictive risk taking these not well understood humans. Identifying local field potential frequency signatures risk-taking may provide therapeutic insight into associated with risk-taking. Eleven patients...
Executive functions, including working memory, are typically assessed clinically with neuropsychological instruments. In contrast, computerized tasks used to test these cognitive functions in laboratory human and animal studies. Little is known of how neural activity captured by relates ability measured clinical instruments and, extension, diagnoses pathological conditions. We therefore sought determine what aspects elicited predictive performance recorded from intracranial electrodes...
Oscillatory activity in the local field potential (LFP) is thought to be a marker of cognitive processes. To understand how it differentiates tasks and brain areas humans, we recorded LFPs 15 adults with intracranial depth electrodes, as they performed visual-spatial shape working memory tasks. Stimulus appearance produced widespread, broad-band activation, including occipital, parietal, temporal, insular, prefrontal cortex, amygdala hippocampus. Occipital cortex was characterized by most...
ABSTRACT The progress of developing an effective closed-loop neuromodulation system for many neurological pathologies is hindered by the difficulties in accurately capturing a useful representation brain’s instantaneous functional state. Existing approaches rely on expert labeling electroencephalography data to develop biomarkers neurophysiological pathology. These techniques do not capture highly complex states brain that are presumed exist between labeled or allow likely possibility...