A5084288585- Vitamin C and Antioxidants Research
- Alzheimer's disease research and treatments
- Vitamin K Research Studies
- Vitamin D Research Studies
- Intensive Care Unit Cognitive Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Medicinal Plants and Neuroprotection
- Trace Elements in Health
- Neuroscience and Neuropharmacology Research
- Heavy Metal Exposure and Toxicity
- Memory and Neural Mechanisms
- Tryptophan and brain disorders
- Anesthesia and Neurotoxicity Research
- Cholinesterase and Neurodegenerative Diseases
- Antioxidant Activity and Oxidative Stress
- Genetic Neurodegenerative Diseases
- Alcoholism and Thiamine Deficiency
- Diet and metabolism studies
- Cholesterol and Lipid Metabolism
- Receptor Mechanisms and Signaling
- Peroxisome Proliferator-Activated Receptors
- Stress Responses and Cortisol
- Traumatic Brain Injury and Neurovascular Disturbances
- Retinoids in leukemia and cellular processes
- Nuclear Receptors and Signaling
Vanderbilt University Medical Center
2015-2025
Vanderbilt University
2013-2024
Vanderbilt Health
2020-2024
California Institute of Technology
2011-2023
John F. Kennedy Center for the Performing Arts
2013-2020
Diabetes Australia
2020
Allen Institute for Brain Science
2006
Royal North Shore Hospital
1960
Mice co-expressing the Swedish amyloid precursor protein mutation (APP(Swe)) and exon 9 deletion (DeltaE9) of PSEN1 gene begin to develop plaques at 6-7 months age. We demonstrate here a spatial learning deficit in 7-month-old APP(Swe) + PSEN1DeltaE9 bigenic mice using an adaptation Barnes maze. were first trained on cued target followed by hidden-target condition. Although quickly learned cued-target version task, they significantly impaired when switched version. In contrast, separate...
The Barnes maze is a spatial memory task that requires subjects to learn the position of hole can be used escape brightly lit, open surface maze. Two experiments assessed relative importance (extra-maze) versus proximal visible cues in solving In Experiment 1, four groups mice were trained either with or without discrete cue marking location hole, which was fixed variable across trials. 2, all target location. identical cued-target from locations. For these mice, sole predictor perfectly...
The precise regulation of synaptic dopamine (DA) content by the DA transporter (DAT) ensures phasic nature signal, which underlies ability to encode reward prediction error, thereby driving motivation, attention, and behavioral learning. Disruptions system are implicated in a number neuropsychiatric disorders, including attention deficit hyperactivity disorder (ADHD) and, more recently, autism spectrum (ASD). An ASD-associated de novo mutation SLC6A3 gene resulting threonine-to-methionine...
Subclinical vitamin C deficiency is widespread in many populations, but its role both Alzheimer's disease and normal aging understudied. In the present study, we decreased brain APPSWE/PSEN1deltaE9 mouse model of by crossing APP/PSEN1+ bigenic mice with SVCT2+/− heterozygous knockout mice, which have lower numbers sodium-dependent transporter required for neuronal transport. performed less well on rotarod task at 5 12 months age compared to littermates. combination genotype...
Abstract Intracellular Vitamin C (VC) is maintained at high levels in the developing brain by activity of sodium-dependent VC transporter 2 (Svct2), suggesting specific functions development. A role as a cofactor for Fe(II)-2-oxoglutarate-dependent dioxygenases has recently been suggested. We show that supplementation neural stem cell cultures derived from embryonic midbrains greatly enhanced differentiation toward midbrain-type dopamine (mDA) neurons, neuronal subtype associated with...
Oxidative stress is implicated in the cognitive deterioration associated with normal aging as well neurodegenerative disorders such Alzheimer's and Parkinson's diseases. We investigated effect of ascorbic acid (vitamin C) on oxidative stress, cognition, motor abilities mice null for gulono-gamma-lactone oxidase (Gulo). Gulo-/- are unable to synthesize depend dietary survival. were given supplements that provided them either levels equal to- or slightly higher than wild-type...
Background: Ergothioneine (ERGO) is a unique antioxidant and rare amino acid available in fungi various bacteria but not higher plants or animals. Substantial research data indicate that ERGO physiological cytoprotectant. Different from other antioxidants need to breach the blood–brain barrier enter brain parenchyma, specialized transporter called OCTN1 has been identified for transporting brain. Purpose: To assess whether consumption of can prevent progress Alzheimer’s disease (AD) on young...
Importance Sepsis is associated with long-term cognitive impairment and worse psychological functional outcomes. Potential mechanisms include intracerebral oxidative stress inflammation, yet little known about the effects of early antioxidant anti-inflammatory therapy on cognitive, psychological, outcomes in sepsis survivors. Objective To describe observed differences vitamin C, thiamine, hydrocortisone between intervention control groups Vitamin Thiamine, Steroids (VICTAS) randomized...