Aaron Barksdale
A5023211531- Cardiac Arrest and Resuscitation
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and healthcare impacts
- Cardiac Ischemia and Reperfusion
- Infection Control and Ventilation
- Trauma and Emergency Care Studies
- Emergency and Acute Care Studies
- Appendicitis Diagnosis and Management
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Burn Injury Management and Outcomes
- Diabetic Foot Ulcer Assessment and Management
- Healthcare Decision-Making and Restraints
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory viral infections research
- Ethics in medical practice
- Intensive Care Unit Cognitive Disorders
- Ultrasound in Clinical Applications
- Radiology practices and education
- SARS-CoV-2 detection and testing
- Vitamin C and Antioxidants Research
- Child Development and Digital Technology
- COVID-19 diagnosis using AI
University of Nebraska Medical Center
2014-2025
St. Luke's Hospital
2023
University of Nebraska at Omaha
2021
Nebraska Medical Center
2021
University of Missouri–Kansas City
2012
Truman Medical Center
2012
Sepsis is a common syndrome with substantial morbidity and mortality. A combination of vitamin C, thiamine, corticosteroids has been proposed as potential treatment for patients sepsis.To determine whether hydrocortisone every 6 hours increases ventilator- vasopressor-free days compared placebo in sepsis.Multicenter, randomized, double-blind, adaptive-sample-size, placebo-controlled trial conducted adult sepsis-induced respiratory and/or cardiovascular dysfunction. Participants were enrolled...
Importance Preclinical models suggest dysregulation of the renin-angiotensin system (RAS) caused by SARS-CoV-2 infection may increase relative activity angiotensin II compared with (1-7) and be an important contributor to COVID-19 pathophysiology. Objective To evaluate efficacy safety RAS modulation using 2 investigational agents, TXA-127 (synthetic [1-7]) TRV-027 (an type 1 receptor–biased ligand), that are hypothesized potentiate action mitigate II. Design, Setting, Participants Two...
Importance Sepsis is associated with long-term cognitive impairment and worse psychological functional outcomes. Potential mechanisms include intracerebral oxidative stress inflammation, yet little known about the effects of early antioxidant anti-inflammatory therapy on cognitive, psychological, outcomes in sepsis survivors. Objective To describe observed differences vitamin C, thiamine, hydrocortisone between intervention control groups Vitamin Thiamine, Steroids (VICTAS) randomized...
Extremity injuries with hemorrhage have been a significant cause of death in civilian medicine and on the battlefield. The use tourniquet as an intervention is necessary for treatment to injured limb; however, subsequent release results serious acute ischemia-reperfusion (IR) injury skeletal muscle neuromuscular junction (NMJ). Much evidence demonstrates that inflammation important factor IR injury. To find effective therapeutic interventions tourniquet-induced injuries, our current study...
SARS-CoV-2 targets angiotensin converting enzyme-2 (ACE2), a key peptidase of the renin-angiotensin system (RAS), which regulates balance vasoconstrictor/inflammatory peptide Ang II and vasodilator/anti-inflammatory Ang-(1-7). Few studies have quantified circulating elements RAS longitudinally in infection their association with COVID-19 outcomes. Thus, we evaluated enzymes peptides mortality among patients COVID-19. Blood samples were collected from 111 new-onset hypoxemia during delta...
Abstract The capability to produce suture material using three‐dimensional (3D) printing technology may have applications in remote health facilities where rapid restocking of supplies is not an option. This a feasibility study evaluating the usability 3D‐printed sutures repair laceration wound when compared with standard material. was manufactured fused deposition modelling 3D printer and nylon filament. Study participants were tasked performing repairs on pigs' feet, first 3‐0 WeGo...
Introduction Frostbite is thought to result from initial vasoconstriction, ischemia, intracellular ice crystal formation, and inflammation caused by reperfusion injury. Corticosteroids have demonstrated beneficial anti-inflammatory effects in the treatment of other ischemia/reperfusion clinical conditions. The objective this study was determine effect dexamethasone (dex) on wound healing, inflammatory response, vasculogenesis a mouse skin frostbite model. Methods Treatment control groups...
Importance Fostamatinib, a spleen tyrosine kinase inhibitor, has been reported to improve outcomes of COVID-19. Objective To evaluate the efficacy and safety fostamatinib in adults hospitalized with COVID-19 hypoxemia. Design, Setting, Participants This multicenter, phase 3, placebo-controlled, double-blinded randomized clinical trial was conducted at 41 US sites 21 international between November 17, 2021, September 27, 2023; last follow-up visit December 31, 2023. were aged 18 years or...
Peripheral arterial disease (PAD) is a common circulatory problem in lower extremities, and the murine ischemic model used to reproduce human PAD. To compare strain differences of skeletal muscle responses ischemia, left femoral artery was blocked by ligation reduce blood flow limb BALB/c C57BL/6 mice. After 6 weeks ligation, functional morphological changes gastrocnemius were evaluated. mice displayed serious muscular dystrophy, including smaller myofibers (524.3 ± 66 µM2), accumulation...
The neuromuscular junction (NMJ) is an important factor to influence skeletal muscle contractile function. Tourniquet-induced ischemia-reperfusion (IR) results in the fragmentation of nicotinic acetylcholine receptors (nAChR) clusters NMJ and impairs neural controlled contraction. Rapsyn, a cytoplasmic nAChR-associated protein concentrates anchors nAChRs postsynaptic membrane participates nAChR assembly at NMJ. Here, we observed effect overexpression Rapsyn on morphological functional...
Tourniquet use is the most effective tool for controlling life-threatening extremity hemorrhage before other treatments and creating bloodless operating fields in surgical procedures. However, tourniquet-induced ischemia-reperfusion (IR) also causes skeletal muscle injury associated secondary end-organ damage. Our previous studies have demonstrated that there are involvements of inflammatory cytokines IR injuries. The objective this study to investigate responses end-organs after mouse...
Frostbite is a clinical condition in which exposure to environmental cold leads freezing of tissue. This can lead significant morbidity, including digit and appendage amputation. As soon as the risk refreezing minimal, current standard care rapidly rewarm frozen tissue circulating warm water bath at 37–39°C.1 However, there no method create temperature-targeted bath. One utilizes basins with manual exchanges. does not circulate requires labor, precise maintenance target temperature...