A5081763838- Pharmacological Effects and Toxicity Studies
- Epilepsy research and treatment
- Pregnancy and Medication Impact
- Asthma and respiratory diseases
- Blood disorders and treatments
- Cancer Risks and Factors
- Metabolism, Diabetes, and Cancer
- Biosimilars and Bioanalytical Methods
- Cannabis and Cannabinoid Research
- Statistical Methods in Clinical Trials
- Anesthesia and Pain Management
- Peripheral Neuropathies and Disorders
- Thyroid and Parathyroid Surgery
- Adipokines, Inflammation, and Metabolic Diseases
- Maternal Mental Health During Pregnancy and Postpartum
- Healthcare and Venom Research
- Inflammatory Myopathies and Dermatomyositis
- 3D IC and TSV technologies
- Adrenal and Paraganglionic Tumors
- Systemic Sclerosis and Related Diseases
- Chronic Lymphocytic Leukemia Research
- Pharmacogenetics and Drug Metabolism
- Computational Drug Discovery Methods
- Diverse Scientific Research Studies
- Analytical Chemistry and Chromatography
Temple University Hospital
2020-2025
University of Minnesota
2018-2025
Pfizer (United States)
2023-2025
Advanced Centre for Treatment, Research and Education in Cancer
2016-2021
Tata Memorial Hospital
2016-2021
Temple University
2021
Community Link
2020
Thrasher Research Fund
2020
Kasturba Medical College, Manipal
2015
Manipal Academy of Higher Education
2015
There is limited information on infant drug exposure via breastfeeding by mothers who are receiving antiepileptic therapy.To provide direct, objective through breast milk.This prospective cohort study was conducted between December 2012 to October 2016, with follow-up in children until 6 years of age at 20 sites across the United States. Data were collected an observational multicenter investigation (Maternal Outcomes and Neurodevelopmental Effects Antiepileptic Drugs [MONEAD]) outcomes...
Abstract Objective To evaluate the pharmacokinetics of a purified oral cannabidiol ( CBD ) capsule administered with and without food in adults refractory epilepsy. Methods Adult patients who were prescribed for seizures, had localization‐related intractable epilepsy ≥4 seizures per month, qualified Minnesota cannabis enrolled. A single dose 99% pure capsules was taken under both fasting (no breakfast) fed (high fat 840‐860 calorie) conditions. Blood sampling plasma concentrations performed...
During pregnancy in women with epilepsy, lower blood concentrations of antiseizure medications can have adverse clinical consequences.
Objective To determine how early lamotrigine clearance (LTG‐CL/F) increases during pregnancy in women with epilepsy and to quantify the relationship of LTG‐CL/F estradiol concentrations gestational week. Methods This was a multicenter, observational study pregnant on no interacting concomitant medications, employing frequent blood sampling prior pregnancy. A population mixed‐effects modeling approach used describe between week estradiol. Akaike information criterion (AIC) compared goodness...
Lamotrigine clearance can change drastically in pregnant women with epilepsy (PWWE) making it difficult to assess the need for dosing adjustments. Our objective was characterize lamotrigine pharmacokinetics PWWE during pregnancy and postpartum along a control group of nonpregnant (NPWWE). The Maternal Outcomes Neurodevelopmental Effects Antiepileptic Drugs (MONEAD) study prospective, observational, 20 site, cohort conducted United States (December 2012 February 2016). Inclusion criteria...
Objectives: Several biotherapeutics modulating targets related to Th2 immunity have been investigated for the treatment of atopic dermatitis (AD) [1-3]. More recently, there has interest in exploring novel multi-pathway combination therapies with potential improved efficacy either through additive or synergistic combinations and alarmin pathways. A quantitative systems pharmacology-based approach incorporating disparate preclinical clinical information from monotherapies can be used...
Pharmacokinetic studies are vital in development and optimization of drugs. While blood samples can be collected either EDTA, heparin or citrate containing tubes for the estimation drug levels plasma, EDTA more commonly used. The purpose this study was to evaluate effects anticoagulants on bioanalysis Six drugs used extensively cancer therapy were selected. Albino wistar rats (N = 6 per drug) dosed with one following intraperitoneally-pemetrexed (50 mg/kg), imatinib erlotinib (25 meropenem...
A sensitive, robust method was developed and validated to quantitate 13 major natural cannabinoid parent metabolite compounds in human plasma at or below 0.5 ng/mL.A liquid chromatography tandem mass spectrometry measure compounds: cannabidiol (CBD), cannabidiolic acid, cannabidivarin, cannabinol, cannabigerol, cannabigerolic cannabichromene, Δ-tetrahydocannabinol (THC), Δ-tetrahydrocannabinolic acid (THCA), Δ-tetrahydrocannabivarin (THCV), 11-hydroxy-Δ-tetrahydrocannbinol (11-OH-THC),...
To evaluate bupivacaine concentrations in maternal plasma and transfer into breast milk women undergoing liposomal infiltration the transversus abdominis plane after cesarean birth.Prospective cohort study of healthy pregnant who underwent birth at term followed by a block using 52 mg hydrochloride 0.25% (20 mL) 266 1.3% mL). Simultaneous blood samples were collected staggered fashion, three to four per patient following timepoints administration: 2, 6, 12, 24, 48, 72, 96 hours....
Maintaining seizure control with lamotrigine is complicated by altered pharmacokinetics and existence of subpopulations in whom clearance increases or remains constant during pregnancy.
Ritlecitinib is a small molecule in clinical development that covalently and irreversibly inhibits Janus kinase 3 (JAK3) the TEC family of kinases (BTK, BMX, ITK, TXK, TEC). This phase 1, open-label, parallel-group study assessed target occupancy functional effects ritlecitinib on JAK3 healthy participants aged 18-60 years who received 50 or 200 mg single doses day 1. Blood samples to assess pharmacokinetics, occupancy, pharmacodynamics were collected over 48 hours. Target was using mass...
Job's syndrome or hyper-immunoglobulin E (HIES) is a heterogeneous complex of immunodeficiencies distinguishes by skin abscesses, recurrent pneumatoceles staphylococcal infections, high serum immunoglobulin levels and eczematous dermatitis. It has two types depends on type gene involved; autosomal-dominant HIES (AD-HIES), which develops due to signal transducer activator transcription 3 autosomal recessive caused DOCK8 mutation. Hereby we present case 13-month-old male child who admitted our...
ABSTRACT Background Paclitaxel is dosed according to body surface area (BSA) but there scant information on actual drug exposure in overweight and obese patients. Methods Early breast cancer patients receiving paclitaxel at 175 mg/m 2 every 3 weeks, two BMI groups (normal, 18–24.9 kg/m overweight/obese, ≥25 , respectively), matched for age, serum albumin bilirubin levels using minimization technique, were included. Sparse pharmacokinetic (PK) sampling was performed 7 time points from 0 h...
SLE is an autoimmune connective tissue disease mostly occurs in women, affects various systems of the body with broad range symptoms and complications. A 31 year old female was admitted October 2013 complaints right lower limb weakness inability to walk for 3 days diagnosed have systemic lupus erythematosus (SLE) remission. detailed medical history revealed multiple admissions, initially Parinauds syndrome due upper midbrain tectal lesion December 2004 when she Primigravida at 32 weeks...
Abstract Introduction: Connective Tissue Disease Related Interstitial Lung (CTD-ILD) is often treated with immunosuppressant medications; common among these Mycophenolate Mofetil (MMF). We hypothesized that co-treatment corticosteroids would impact disease progression. Methods: examined a consecutive cohort of CTD-ILD patients followed at Temple University Hospital in Philadelphia, PA since 2015 who had pulmonary function tests (PFTs) performed by American Thoracic Society (ATS)/European...