A5073464972- Traumatic Brain Injury and Neurovascular Disturbances
- Epilepsy research and treatment
- Traumatic Brain Injury Research
- Cardiac Arrest and Resuscitation
- EEG and Brain-Computer Interfaces
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Pharmacological Effects and Toxicity Studies
- Psychosomatic Disorders and Their Treatments
- Neonatal and fetal brain pathology
- Cerebrovascular and Carotid Artery Diseases
- Cerebrospinal fluid and hydrocephalus
- HIV/AIDS drug development and treatment
- Hepatitis C virus research
- Intensive Care Unit Cognitive Disorders
- Hemodynamic Monitoring and Therapy
- Sepsis Diagnosis and Treatment
- HIV Research and Treatment
- Research on Leishmaniasis Studies
- Stroke Rehabilitation and Recovery
- Intracerebral and Subarachnoid Hemorrhage Research
- HIV/AIDS Research and Interventions
- Heart Rate Variability and Autonomic Control
Massachusetts General Hospital
2016-2025
Harvard University
2016-2025
Kennedy Krieger Institute
2025
Mass General Brigham
2025
Center for Neuro-Oncology
2020-2024
University of Michigan
2016-2023
Medical University of South Carolina
2021-2023
King's College London
2023
Université Paris Cité
2023
Institut Pasteur
2021-2023
INTRODUCTION In the early 2000s, a subcommittee of American Clinical Neurophysiology Society (ACNS) set out to “standardize terminology periodic and rhythmic EEG patterns in critically ill aid future research involving such patterns.” The initial proposed was published 2005.1 This presented at many meetings on several continents, subjected multiple rounds testing interrater reliability, underwent revisions, then as an ACNS guideline 2013.2 Interrater agreement 2012 version (published 2013)...
Background: Rapid and easy clinical assessments for volumes of infarction perfusion mismatch are needed. We tested whether simple geometric models generated accurate estimates these volumes.
See Schiff (doi:10.1093/awx209) for a scientific commentary on this article. Patients with acute severe traumatic brain injury may recover consciousness before self-expression. Without behavioural evidence of at the bedside, clinicians render an inaccurate prognosis, increasing likelihood withholding life-sustaining therapies or denying rehabilitative services. Task-based functional magnetic resonance imaging and electroencephalography techniques have revealed covert in chronic setting, but...
Abstract Background Neurovascular coupling (NVC) refers to the process of aligning cerebral blood flow with neuronal metabolic demand. This study explores potential contralateral NVC—linking neural electrical activity on stroke side velocity (CBFV) contralesional side—as a marker physiological function brain. Our aim was examine association between NVC and neurological outcomes in patients ischemic following endovascular thrombectomy. Methods We concurrently recorded CBFVs middle arteries...
Some patients with mild or improving ischemic stroke symptoms do not receive intravenous tissue plasminogen activator (tPA) because they look "too good to treat" (TGT); however, some have poor outcomes.We retrospectively analyzed data from a prospective single-center study between 2002 and 2004. TGT were those arriving within 3 hours of symptom onset treated tPA solely symptoms.Of 128 presenting hours, 41 (34%) given stroke. Of the patients, 11 (27%) died discharged home neurological...
Abstract Objectives: Telemedicine‐enabled acute stroke consultation (TeleStroke) may be useful to determine eligibility for treatment with tissue plasminogen activator (tPA) and provide support emergency departments without on‐site expertise. Methods: Emergency physicians consulted neurologists via two‐way videoconferencing in the evaluation of patients possible stroke. History, neurologic examination, computed tomography head were reviewed tPA. Interpretations compared inter‐rater...
Background and Purpose— Because of a shortage stroke specialists, many outlying or “spoke” hospitals initiate intravenous (IV) thrombolysis using telemedicine telephone consultation before transferring patients to regional center (RSC) hub. We analyzed complications outcomes treated with IV tissue plasminogen activator (tPA) the “drip ship” approach compared those directly at RSC. Methods— A retrospective review our Get With Guidelines Stroke (GWTG-Stroke) database from 01/2003 03/2008...
Objective Delayed cerebral ischemia (DCI) is a common, disabling complication of subarachnoid hemorrhage (SAH). Preventing DCI key focus neurocritical care, but interventions carry risk and cannot be applied indiscriminately. Although retrospective studies have identified continuous electroencephalographic (cEEG) measures associated with DCI, no study has characterized the accuracy cEEG sufficient rigor to justify using it triage patients or clinical trials. We therefore prospectively...
Abstract Coma and disordered consciousness are common manifestations of acute neurological conditions among the most pervasive challenging aspects treatment in neurocritical care. Gaps exist patient assessment, outcome prognostication, directed specifically at improving cognitive recovery. In 2019, Neurocritical Care Society (NCS) launched Curing Campaign order to address “grand challenge” management patients with coma decreased consciousness. One first steps was bring together a Scientific...
Super-refractory status epilepticus (SRSE) is a life-threatening form of that continues or recurs despite 24 hours more anesthetic treatment. We conducted multicenter, phase 1/2 study in SRSE patients to evaluate the safety and tolerability brexanolone (USAN; formerly SAGE-547 Injection), proprietary, aqueous formulation neuroactive steroid, allopregnanolone. Secondary objectives included pharmacokinetic assessment open-label evaluation response during after third-line agent (TLA)...
<h3>Importance</h3> Seizure risk stratification is needed to boost inpatient seizure detection and improve continuous electroencephalogram (cEEG) cost-effectiveness. 2HELPS2B can address this need but requires validation. <h3>Objective</h3> To use an independent cohort validate the score develop a practical guide for its use. <h3>Design, Setting, Participants</h3> This multicenter retrospective medical record review analyzed clinical EEG data from patients 18 years or older with indication...
Abstract Objective This study was undertaken to describe patterns of benzodiazepine use as first‐line treatment status epilepticus (SE) and test the association doses with response second‐line agents in patients enrolled Established Status Epilepticus Treatment Trial (ESETT). Methods Patients refractory an adequate dose benzodiazepines for SE were ESETT. Choice benzodiazepine, given prior administration agent, route administration, setting, patient weight characterized. These compared...
Seizures (SZs) and other SZ-like patterns of brain activity can harm the contribute to in-hospital death, particularly when prolonged. However, experts qualified interpret EEG data are scarce. Prior attempts automate this task have been limited by small or inadequately labeled samples not convincingly demonstrated generalizable expert-level performance. There exists a critical unmet need for an automated method classify SZs events with reliability. This study was conducted develop validate...
Quantitatively evaluate whether screening with compressed spectral arrays (CSAs) is a practical and time-effective protocol for assisting expert review of continuous EEG (cEEG) studies in hospitalized adults.Three neurophysiologists reviewed the reported findings first 30 minutes 118 cEEGs, then used CSA to guide subsequent ("CSA-guided review" protocol). Reviewers viewed 120 seconds raw data surrounding suspicious segments. The same performed independent page-by-page visual interpretation...
Abstract Coma and disorders of consciousness (DoC) are highly prevalent constitute a burden for patients, families, society worldwide. As part the Curing Campaign, Neurocritical Care Society partnered with National Institutes Health to organize symposium bringing together experts from all over world develop research targets DoC. The conference was structured along six domains: (1) defining endotype/phenotypes, (2) biomarkers, (3) proof-of-concept clinical trials, (4) neuroprognostication,...
<h3>Importance</h3> Mild traumatic brain injury (mTBI) may impair the ability to work. Strategies facilitate return work are understudied. <h3>Objective</h3> To assess employment and economic outcomes for employed, working-age adults with mTBI in 12 months after association between employer assistance. <h3>Design, Setting, Participants</h3> Using data from Transforming Research Clinical Knowledge Traumatic Brain Injury (TRACK-TBI) study, a cohort study of patients presenting emergency...