A5005012109- Transcranial Magnetic Stimulation Studies
- Functional Brain Connectivity Studies
- Neurological disorders and treatments
- Pain Management and Treatment
- Neural and Behavioral Psychology Studies
- Vagus Nerve Stimulation Research
- EEG and Brain-Computer Interfaces
- Electroconvulsive Therapy Studies
- Advanced MRI Techniques and Applications
- Treatment of Major Depression
- Advanced Neuroimaging Techniques and Applications
- Obsessive-Compulsive Spectrum Disorders
- Neuroscience and Neural Engineering
- Migraine and Headache Studies
- Stroke Rehabilitation and Recovery
- Heart Rate Variability and Autonomic Control
- Muscle activation and electromyography studies
- Attention Deficit Hyperactivity Disorder
- Bipolar Disorder and Treatment
- Psychosomatic Disorders and Their Treatments
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neuroscience and Neuropharmacology Research
- Neurology and Historical Studies
- Motor Control and Adaptation
- Neural dynamics and brain function
Medical University of South Carolina
2016-2025
Ralph H. Johnson VA Medical Center
2016-2025
Kansas State University
2025
The University of Sydney
2001-2024
Yerevan State Medical University
2024
Sri Eshwar College of Engineering
2024
McLean Hospital
2020-2023
Brown University
1998-2023
Harvard University
2023
Yale University
2023
Daily left prefrontal repetitive transcranial magnetic stimulation (rTMS) has been studied as a potential treatment for depression, but previous work had mixed outcomes and did not adequately mask sham conditions.To test whether daily rTMS safely effectively treats major depressive disorder.Prospective, multisite, randomized, active sham-controlled (1:1 randomization), duration-adaptive design with 3 weeks of weekday (fixed-dose phase) followed by continued blinded up to another in...
Converging evidence points to hypofunction of the left prefrontal cortex in depression. Repetitive transcranial magnetic stimulation (rTMS) activates neurons near surface brain. We questioned whether daily rTMS might improve mood depressed subjects and report a pilot study such treatment six highly medication-resistant inpatients. Depression scores significantly improved for group as whole (Hamilton Scores decreased from 23.8 ± 4.2 (s.d.) at baseline 17.5 8.4 after treatment; t = 3.03, 5DF,...
The specific brain regions involved in the normal emotional states of transient sadness or happiness are poorly understood. authors therefore sought to determine if H2(15)O positron emission tomography (PET) might demonstrate changes regional cerebral blood flow (rCBF) associated with healthy adult women.Eleven and never mentally ill women were scanned, by using PET H2(15)O, during happy, sad, neutral induced recalling affect-appropriate life events looking at human faces.Compared condition,...
Preliminary studies have indicated that daily left prefrontal repetitive transcranial magnetic stimulation might antidepressant activity. The authors sought to confirm this finding by using a double-blind crossover design.Twelve depressed adults received in random order 2 weeks of active treatment (repetitive stimulation, 20 Hz at 80% motor threshold) and sham treatment.Changes from the relevant phase baseline scores on 21-item Hamilton depression scale showed significantly improved mood...
To provide expert recommendations for the safe and effective application of repetitive transcranial magnetic stimulation (rTMS) in treatment major depressive disorder (MDD).Participants included a group 17 clinicians researchers with expertise clinical rTMS, representing both National Network Depression Centers (NNDC) rTMS Task Group American Psychiatric Association Council on Research (APA CoR) Force Novel Biomarkers Treatments.The consensus statement is based review extensive literature...
Non-invasive imaging of human inter-regional neural connectivity by positron emission tomography (PET) during transcranial magnetic stimulation (TMS) was performed. The hand area primary motor cortex (M1) in the left cerebral hemisphere stimulated with TMS while local and remote effects were recorded PET. At site, increased blood flow (12-20%) a highly focal manner, without an inhibitory surround. Remote covariances, index M1, also focal. Connectivity patterns established non-human species...
<h3>Background</h3> Functional imaging studies have recently demonstrated that specific brain regions become active in cocaine addicts when they are exposed to stimuli. To test whether there regional activity differences during alcohol cue exposure between alcoholic subjects and social drinkers, we designed a functional magnetic resonance (fMRI) protocol involving alcohol-specific cues. <h3>Methods</h3> Ten non–treatment-seeking adult (2 women) (mean [SD] age, 29.9 [9.9] years) as well 10...
(1992). Changing nineteenth century views on the origins of cerebral palsy: W.J. Little and Sigmund Freud. Journal History Neurosciences: Vol. 1, No. pp. 29-37.
Major depressive disorder (MDD) is a prevalent and disabling condition, many patients do not respond to available treatments. Deep transcranial magnetic stimulation (dTMS) new technology allowing non-surgical of relatively deep brain areas. This the first double-blind randomized controlled multicenter study evaluating efficacy safety dTMS in MDD. We recruited 212 MDD outpatients, aged 22–68 years, who had either failed one four antidepressant trials or tolerated at least two treatments...
Article Abstract Background: Vagus nerve stimulation (VNS) had antidepressant effects in an initial open, acute phase pilot study of 59 participants a treatment-resistant major depressive episode (MDE). We examined the adjunctive VNS over 24 months this cohort. Method: Adult outpatients (N = 59) with chronic or recurrent disorder bipolar (I II) and experiencing treatment-resistant, nonpsychotic MDE (DSM-IV criteria) received 2 years VNS. Changes psychotropic medications stimulus parameters...