A5045418513- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Schizophrenia research and treatment
- Obsessive-Compulsive Spectrum Disorders
- Mental Health Research Topics
- Global Health Workforce Issues
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Higher Education Research Studies
- Career Development and Diversity
- Biofield Effects and Biophysics
- Health, psychology, and well-being
- Transcranial Magnetic Stimulation Studies
- Advanced MRI Techniques and Applications
- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Evaluation of Teaching Practices
- Heart Rate Variability and Autonomic Control
- Chronic Lymphocytic Leukemia Research
- Neural and Behavioral Psychology Studies
- Global Health and Surgery
- Psychosomatic Disorders and Their Treatments
- Memory and Neural Mechanisms
- Attention Deficit Hyperactivity Disorder
- Primary Care and Health Outcomes
University of California, San Diego
2023-2024
University of California, Davis
2018-2020
Yale University
2019
University of Cambridge
2013-2016
Studies show evidence of longitudinal brain volume decreases in schizophrenia. We studied changes and their relation to symptom severity, level function, cognition, antipsychotic medication participants with schizophrenia control from a general population based birth cohort sample relatively long follow-up period almost decade. All members the Northern Finland Birth Cohort 1966 any psychotic disorder random not having psychosis were invited for MRI scan, clinical cognitive assessment during...
Abstract Current knowledge about functional connectivity in obsessive-compulsive disorder (OCD) is based on small-scale studies, limiting the generalizability of results. Moreover, majority studies have focused only predefined regions or networks rather than throughout entire brain. Here, we investigated differences resting-state between OCD patients and healthy controls (HC) using mega-analysis data from 1024 1028 HC 28 independent samples ENIGMA-OCD consortium. We assessed group...
Progressive brain volume loss in schizophrenia has been reported previous studies but its cause and regional distribution remains unclear. We investigated progressive reductions correlations with potential mediators.Participants were drawn from the Northern Finland Birth Cohort 1966. A total of 33 individuals 71 controls MRI scanned at baseline (mean age=34.7, SD=0.77) follow-up age=43.4, SD=0.44). Regional change differences associations clinical mediators examined using FSL voxelwise...
The hallmark of chronic myelogenous leukaemia (CML) is the presence Philadelphia chromosome and its resultant fusion message, BCR‐ABL , protein, p210. Patients with CML in blast crisis, or positive acute lymphoblastic (ALL), can have a smaller transcript possessing only first exon BCR fused to ABL . This encodes 190 kD protein which more strongly transforming than p210 derived from larger CML‐associated transcript. We performed RT‐PCR on samples patients phase determine frequency mechanism...
Abstract Background Multiple lines of evidence suggest the presence altered neuroimmune processes in patients with schizophrenia (Sz) and severe mood disorders. Recent studies using a novel free water diffusion tensor imaging (FW DTI) approach, proposed as putative biomarker neuroinflammation, atrophy, or edema, have shown significantly increased FW Sz. However no to date investigated longitudinal stability alterations during early course psychosis, nor focused separately on FE psychosis Sz...
Cognitive behavioral therapy (CBT) is a first-line treatment for obsessive-compulsive disorder (OCD), but clinical response difficult to predict. In this study, we aimed develop predictive models using and neuroimaging data from the multicenter Enhancing Neuro-Imaging Genetics through Meta-Analysis (ENIGMA)-OCD consortium. Baseline resting-state functional magnetic imaging (rs-fMRI) 159 adult patients aged 18-60 years (88 female) with OCD who received CBT at four treatment/neuroimaging sites...
Recent diffusion imaging studies using free-water (FW) elimination have shown increased FW in gray matter (GM) and white (WM) first-episode psychosis (FEP) lower corrected fractional anisotropy (FAt) WM chronic schizophrenia. However, little is known about the longitudinal stability clinical significance of these findings. To determine tissue-specific FAt abnormalities FEP, as part a multicenter Spanish study, 132 FEP 108 healthy controls (HC) were clinically characterized underwent...
Brain development during childhood and adolescence differs between boys girls. Structural changes continue adulthood old age, particularly in terms of brain volume reductions that accelerate beyond age 35 years. We investigated whether structural change mid-life men women. 43 28 women from the Northern Finland 1966 Birth Cohort underwent MRI scans at 33-35 (SD=0.67) then again 42-44 (SD=0.41). examined sex differences total percentage (PBVC) regional with FSL SIENA software. Women showed...
Abstract Background Identifying risk factors of individuals in a clinical-high-risk state for psychosis are vital to prevention and early intervention efforts. Among prodromal abnormalities, cognitive functioning has shown intermediate levels impairment CHR relative first-episode healthy controls, highlighting potential role as factor transition other negative clinical outcomes. The current study used the AX-CPT, brief 15-min computerized task, determine whether control impairments at...
This paper presents a survey tool for assessing undergraduate STEM environments at institutions of higher learning. Such surveys typically appear in methodology sections focused, hypothesis-driven papers written by and education studies specialists. We sought to compose different kind tool, one that enables instructors, nonspecialists educational research, probe climate their broad, exploratory terms. accomplished this goal assembling diverse research team students faculty, those who...
Current knowledge about functional connectivity in obsessive-compulsive disorder (OCD) is based on small-scale studies, limiting the generalizability of results. Moreover, majority studies have focused only predefined regions or networks rather than throughout entire brain. Here, we investigated differences resting-state between OCD patients and healthy controls (HC) using mega-analysis data from 1,024 1,028 HC 28 independent samples ENIGMA-OCD consortium. We assessed group whole-brain at...
Introduction Long duration of untreated psychosis (DUP) has been associated to brain morphological changes in schizophrenia cross sectional analyses. It is unclear DUP relates volume change over time. Aims Our aim was analyze the association between length and total a general population based sample. Methods All members Northern Finland 1966 Birth Cohort (NFBC1966) known have had psychotic illness were invited for field study at age 34-years (in average 10 year after onset psychosis) follow...
Tēnā koutou katoa and welcome to Issue 35 of Te Hautaka o ngā Akongā Rongoā, the New Zealand Medical Student Journal (NZMSJ). The theme this issue is “Health Literacy”, which has become an increasingly important topic for medical professionals general public alike. It our great privilege share with readers insightful high-quality articles by authors both domestic abroad. health literacy workforce crucial successful patient-centred healthcare. Health not solely understanding pathophysiology a...
Tēnā koutou katoa and welcome to Issue 34 of Te Hautaka o ngā Akongā Rongoā, the New Zealand Medical Student Journal (NZMSJ). The theme this issue is “Global Health,” which an important topic for medical students health professionals. It our privilege share with readers a wide range insightful high-quality articles by care professional students, clinicians, academics from Aotearoa abroad. Global has been thrust into spotlight ongoing coronavirus disease 2019 (COVID-19) pandemic, but it long...