A5017005797- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Functional Brain Connectivity Studies
- Mental Health and Psychiatry
- Mental Health Research Topics
- Obsessive-Compulsive Spectrum Disorders
- Tryptophan and brain disorders
- Advanced Neuroimaging Techniques and Applications
- Autism Spectrum Disorder Research
- Neurotransmitter Receptor Influence on Behavior
- Cannabis and Cannabinoid Research
- Child and Adolescent Psychosocial and Emotional Development
- Psychosomatic Disorders and Their Treatments
- Electroconvulsive Therapy Studies
- Diet and metabolism studies
- Advanced MRI Techniques and Applications
- Pharmacological Effects and Toxicity Studies
- Genetic Associations and Epidemiology
- Personality Disorders and Psychopathology
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Attention Deficit Hyperactivity Disorder
- Epilepsy research and treatment
- Nerve injury and regeneration
- Neurological disorders and treatments
- Maternal Mental Health During Pregnancy and Postpartum
Centro de Investigación Biomédica en Red de Salud Mental
2016-2025
Parc de Salut
2015-2025
Universitat Pompeu Fabra
2022-2025
Hospital del Mar Research Institute
2016-2025
Instituto de Salud Carlos III
2022-2025
Hospital Del Mar
2016-2025
Municipal Institute for Medical Research
2014-2024
Instituto de Neurociencias
2023
Universitat Autònoma de Barcelona
2014-2022
Universitat de Barcelona
2004-2022
Negative symptoms are currently viewed as having a 2-dimensional structure, with factors reflecting diminished expression (EXP) and motivation pleasure (MAP). However, several factor-analytic studies suggest that the consensus around model is premature. The current study investigated cross-culturally validated factorial structure of BNSS-rated negative across range cultures languages.Participants included individuals diagnosed psychotic disorder who had been rated on Brief Symptom Scale...
First-episode psychosis has an annual incidence rate of 24.6 to 40.9 per 100,000 population, and most individuals develop chronic disorders, such as schizophrenia or affective psychosis. The first two five years are thought be key determinants long-term functional clinical prognosis. This study aimed determine the two-year course illness in first-episode psychosis, including diagnosis, relapse, functioning factors related these variables.A total 140 patients who experienced a episode were...
Although there is recent evidence that cells from the peripheral immune system can gain access to central nervous in certain conditions such as multiple sclerosis, their role has not been assessed psychosis. Here, we aimed explore whether blood cell count was associated with brain volume and/or clinical symptomatology. A total of 218 participants (137 first-episode psychosis patients [FEP] and 81 healthy controls [HC]) were included study. For each participant, a T1 structural image...
Gene-environment (GxE) interactions have been related to psychosis spectrum disorders, involving multiple common genetic variants in genes with very small effect sizes, and several environmental factors that constitute a dense network of exposures named the exposome. Here, we aimed analyze GxE cohort 310 first-episode psychotic (FEP) 236 healthy controls, by using aggregate scores estimated large populations such as polygenic risk score for schizophrenia (PRS-SCZ) Maudsley (ERS). In contrast...
The extreme variability in symptom presentation reveals that individuals diagnosed with a first-episode psychosis (FEP) may encompass different sub-populations potentially illness courses and, hence, treatment needs. Previous studies have shown sociodemographic and family environment factors are associated more unfavorable trajectories. aim of this study was to examine the dimensional structure symptoms identify individuals' trajectories at early stage potential risk poor outcomes follow-up...
Abstract To assess the role of age (early onset psychosis-EOP < 18 years vs. adult psychosis-AOP) and diagnosis (schizophrenia spectrum disorders-SSD bipolar disorders-BD) on duration untreated psychosis (DUP) prodromal symptoms in a sample patients with first episode psychosis. 331 (7–35 old) were recruited 174 (52.6%) diagnosed SSD or BD at one-year follow-up through multicenter longitudinal study. The Symptom Onset Schizophrenia (SOS) inventory, Positive Negative Syndrome Scale...
Brain connectivity and neurological soft signs (NSS) are reportedly abnormal in schizophrenia unaffected relatives, suggesting they might be useful neurobiological markers of the illness. NSS discrete sensorimotor impairments thought to correspond deviant brain development. Although support hypothesis that involves disruption functional circuits involving several hetero modal association areas, little is known about relationship between connectivity. We explored abnormalities default mode...
Abstract Objectives Negative symptom studies frequently use single composite scores as indicators of severity and primary endpoints in clinical trials. Factor analytic external validation do not support this practice but rather suggest a multidimensional construct. The current study used structural equation modeling (SEM) to compare competing dimensional models negative symptoms determine the number latent dimensions that best capture variance biological, psychological, variables known have...
Clozapine is often underused due to concerns about adverse drug reactions (ADRs) but studies into their prevalences are inconclusive. We therefore comprehensively examined of clozapine-associated ADRs in individuals with schizophrenia and demographic clinical factors associated occurrence. Data from a multi-center study (n=698 participants) were collected. The mean number during clozapine treatment was 4.8, 2.4% participants reporting no ADRs. most common hypersalivation (74.6%), weight gain...
The application of personalized medicine in patients with first-episode psychosis (FEP) requires tools for classifying according to their response treatment, considering both treatment efficacy and toxicity. However, several limitations have hindered its translation into clinical practice. Here, we describe the rationale, aims methodology Applied Pharmacogenetics Predict Response Treatment First Psychotic Episode (the FarmaPRED-PEP project), which develop validate predictive algorithms...
Relapsing after a first episode of schizophrenia (FES) is main predictor clinical and functional prognosis. Brain-derived neurotrophic factor (BDNF) plays critical role in neuronal development plasticity, its signaling may be altered by successive relapses. We assessed the impact relapse expression 2 isoforms BDNF tropomyosin-related kinase B (TrkB) receptor (active full-length TrkB-F inactive truncated TrkB-T) peripheral blood mononuclear cells from 53 FES patients remission followed up for...
Clozapine is highly effective for treatment-resistant schizophrenia but underutilized due to patient and clinician-related concerns. Little known about the general level of satisfaction with clozapine determinants thereof. We therefore explored in individuals diagnosed spectrum disorders (SSDs). Cross-sectional data from 480 users were used examine demographic clinical factors, including symptom severity, treatment response, adverse drug reactions (ADRs). Patient was self-rated on a scale 1...
Background and objective Low back pain (LBP) is a very common problem faced by people globally; with prevalence rate of almost 84%, it nowadays commonly seen in the young adult population too. This also prone to sedentary lifestyle, leading hamstring tightness. As this has little time spare terms long-term treatment, Mulligan traction straight leg raise (TSLR) technique might be ideal for them as effective even short amount may help treat LBP tightness noninvasive manner improve flexibility...