A5028131133- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- Mental Health Research Topics
- Mental Health and Psychiatry
- Neural dynamics and brain function
- Attention Deficit Hyperactivity Disorder
- Memory and Neural Mechanisms
- Neuroscience and Music Perception
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Bipolar Disorder and Treatment
- Psychosomatic Disorders and Their Treatments
- Neuroendocrine regulation and behavior
- Visual perception and processing mechanisms
- Health Systems, Economic Evaluations, Quality of Life
- Treatment of Major Depression
- Obsessive-Compulsive Spectrum Disorders
- Neurotransmitter Receptor Influence on Behavior
- EEG and Brain-Computer Interfaces
- Tryptophan and brain disorders
- Child and Adolescent Psychosocial and Emotional Development
- Cognitive Abilities and Testing
- Advanced Neuroimaging Techniques and Applications
- Neuroscience of respiration and sleep
- Infant Health and Development
University of Maryland, Baltimore
2016-2025
University of Mary
2013-2025
Connecticut Mental Health Center
2023
Yale University
2023
University of Chicago
2023
Kent State University
2019-2021
University of California, San Diego
2021
Hiroshima University
2021
University of California, Davis
2021
University of Maryland, College Park
2012-2020
Objective: The lack of an accepted standard for measuring cognitive change in schizophrenia has been a major obstacle to regulatory approval cognition-enhancing treatments. A primary mandate the National Institute Mental Health’s Measurement and Treatment Research Improve Cognition Schizophrenia (MATRICS) initiative was develop consensus battery clinical trials treatments through broadly based scientific evaluation measures. Method: MATRICS Neurocognition Committee evaluated more than 90...
Impaired Wisconsin Card Sorting Test (WCST) performance has been one critical piece of evidence suggesting frontal lobe dysfunction in schizophrenia. However, the specific cognitive processes underlying impaired have not identified. WCST schizophrenia might part reflect a fundamental working memory deficit.We examined 30 normal subjects and 36 patients with on neuropsychological battery including novel measure memory-letter-number (LN) span.Patients were LN span performance, which was also...
Objective: The consensus cognitive battery developed by the National Institute of Mental Health’s (NIMH’s) Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative includes 10 independently tests that are recommended as standard for clinical trials cognition-enhancing interventions schizophrenia. To facilitate interpretation results from MATRICS Consensus Cognitive Battery using a common scaling across tests, normative data were obtained single...
Although intellectual and neurocognitive deficits accompany schizophrenia, there are inconsistencies in the literature concerning issues of decline, premorbid deficits, a modal deficit pattern, preserved abilities.A battery neuropsychological tests was administered once to 117 consecutively admitted patients with chronic schizophrenia group 27 healthy control subjects examine patterns current intellect (measured by means reading scores IQ, respectively) attendant cognitive profiles using...
Objective: Nicotinic acetylcholine receptors are possible therapeutic targets for schizophrenia, as shown by neurobiological and molecular evidence deficiencies in expression of α 7 -nicotinic receptors. Patients’ heavy smoking suggests attempted self-medication through this mechanism. The agent 3-(2,4-dimethoxybenzylidene) anabaseine (DMXB-A) is a partial agonist can be taken orally. A phase 1 trial showed cognitive enhancement schizophrenia. Method: Thirty-one subjects with schizophrenia...
Patients with schizophrenia frequently present negative symptoms and cognitive impairments for which no effective treatments are known. Agents that act at the glycine site of N-methyl-D-aspartic acid (NMDA) glutamatergic receptor have been suggested as promising moderate to severe impairments.The Cognitive Negative Symptoms in Schizophrenia Trial (CONSIST) was a 16-week double-blind, double-dummy, parallel group, randomized clinical trial adjunctive glycine, D-cycloserine, or placebo...
Familial neuropsychological deficits are well established in schizophrenia but remain less characterized other psychotic disorders. This study from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium 1) compares cognitive impairment and bipolar disorder with psychosis, 2) tests a continuum model of dysfunction disorders, 3) reports familiality impairments across 4) evaluates among nonpsychotic relatives without cluster A personality traits.
<h3>Context</h3>Negative symptoms are a core feature of schizophrenia, but their pathogenesis remains unclear. Negative defined by the absence normal function. However, there must be productive mechanism that leads to this absence.<h3>Objective</h3>To test reinforcement learning account suggesting negative result from failure in representation expected value rewards coupled with preserved loss-avoidance learning.<h3>Design</h3>Participants performed probabilistic paradigm involving stimulus...
Previous research has shown that patients with schizophrenia are impaired in reinforcement learning tasks. However, behavioral curves such tasks originate from the interaction of multiple neural processes, including basal ganglia- and dopamine-dependent (RL) system, but also prefrontal cortex-dependent cognitive strategies involving working memory (WM). Thus, it is unclear which specific system induces impairments schizophrenia. We recently developed a task computational model allowing us to...
This study was designed to ascertain the degree and specificity of cognitive impairments in patients with schizophrenia affective disorders.Cognitive function assessed a neuropsychological test battery consecutively admitted (N = 57), unipolar depression 29), bipolar disorder 16).The performance schizophrenic group significantly below that groups disorders on measures attention psychomotor speed, verbal visual memory, problem solving abstraction. IQ lower appeared have deteriorated from...