A5022676598- Schizophrenia research and treatment
- Personality Disorders and Psychopathology
- Bipolar Disorder and Treatment
- Functional Brain Connectivity Studies
- Mental Health and Psychiatry
- Advanced Neuroimaging Techniques and Applications
- Child and Adolescent Psychosocial and Emotional Development
- Obsessive-Compulsive Spectrum Disorders
- Psychotherapy Techniques and Applications
- Epilepsy research and treatment
- Psychosomatic Disorders and Their Treatments
- Treatment of Major Depression
- Attention Deficit Hyperactivity Disorder
- Diet and metabolism studies
- Electroconvulsive Therapy Studies
- Neural dynamics and brain function
- Mental Health Research Topics
- Neurotransmitter Receptor Influence on Behavior
- Advanced MRI Techniques and Applications
- Tryptophan and brain disorders
- Neural and Behavioral Psychology Studies
- Genetic Associations and Epidemiology
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Pharmaceutical studies and practices
- Mental Health Treatment and Access
University of Minnesota
2009-2018
Institute of Behavioral Sciences
2007-2017
Minneapolis VA Health Care System
2015
Harvard University
2014
University of Iowa
2014
McLean Hospital
2014
University of Minnesota Medical Center
2004-2014
Resonance Research (United States)
2011
University of Minnesota System
2008
Twin Cities Orthopedics
2008
This study was designed to ascertain the degree and specificity of cognitive impairments in patients with schizophrenia affective disorders.Cognitive function assessed a neuropsychological test battery consecutively admitted (N = 57), unipolar depression 29), bipolar disorder 16).The performance schizophrenic group significantly below that groups disorders on measures attention psychomotor speed, verbal visual memory, problem solving abstraction. IQ lower appeared have deteriorated from...
Psychiatric symptoms and cognition were assessed in 13 patients with schizophrenia, one patient schizoaffective disorder, psychosis not otherwise specified while they received a conventional neuroleptic again after an average of 15 months on clozapine. Despite improvements psychiatric symptoms, attention, memory, higher-level problem-solving essentially unchanged. This suggests that certain cognitive deficits are relatively independent psychotic probably central enduring features the...
Comprehensive NeuroScience, Inc., 21 Bloomingdale
The present study was undertaken to survey the prevalence of mental disorder in juvenile justice facilities and compare health needs for females males. Girls displayed significantly more than boys. estimated boys 27%, compared with 84% girls. difference is highly significant discussed terms service system issues that affect males differently. ©1997 John Wiley & Sons, Ltd.
Twenty-two patients meeting the criteria for borderline or schizotypal personality disorder both participated in a prospective, nonblind 12-week trial of fluoxetine. There were significant reductions self-injury and scores on Hopkins Symptom Checklist regardless diagnosis. The results suggest that controlled trials fluoxetine investigations serotonergic system these disorders would be useful.
Previous studies have found varying relationships between cognitive functioning and brain volumes in patients with schizophrenia. However, cortical thickness may more closely reflect cytoarchitectural characteristics than gray matter density or volume estimates. Here, we aimed to compare associations regional variation executive functions, memory, as well verbal spatial processing schizophrenia healthy controls (HCs). We obtained magnetic resonance imaging neuropsychological data for 131 138...
The authors compared the efficacy and tolerability of low moderate dosages extended-release quetiapine in adults with borderline personality disorder.Ninety-five participants DSM-IV disorder were randomly assigned to receive 150 mg/day (the low-dosage group; N=33), 300 moderate-dosage or placebo (N=29). Total score over time on clinician-rated Zanarini Rating Scale for Borderline Personality Disorder ("Zanarini scale") was analyzed a mixed-effects model accounting informative...
Borderline personality disorder (BPD) is associated with symptoms such as affect dysregulation, impaired sense of self, and self-harm behaviors. Neuroimaging research on BPD has revealed structural functional abnormalities in specific brain regions connections. However, little known about the topological organizations networks BPD. We collected resting-state magnetic resonance imaging (fMRI) data from 20 patients 10 healthy controls, constructed frequency-specific by correlating...
Substance abusers with borderline personality disorder (n = 34) were compared substance who not 89) on measures of impulsivity, coping skills, hostility, negative affect, and triggers for craving or relapse. Borderline abused more substances over the course their lifetime scored significantly higher impulsivity. utilized escape/avoidance mechanisms often, used problem solving positive reappraisal less often than nonborderline abusers. Borderlines had cravings relapses triggered by emotional...
Regional gray matter (GM) abnormalities are well known to exist in patients with chronic schizophrenia. Voxel-based morphometry (VBM) has been previously used on structural magnetic resonance images (MRI) data characterize these abnormalities. Two multisite schizophrenia studies, the Functional Biomedical Informatics Research Network and Mind Clinical Imaging Consortium, which include 9 collection sites, evaluating efficacy of pooling imaging across centers. Such a could yield increased...
Background: Emerging evidence implicates white matter (WM) abnormalities in the pathophysiology of schizophrenia. However, there is considerable heterogeneity presentation WM existing studies. The object this study was to evaluate integrity a large sample patients with first-episode (FE) and chronic schizophrenia comparison matched control groups. Our goal assess whether findings occurred early illness or these developed over time. Methods: Participants included 114 (31 FE 83 patients) 138...
Despite the prevalence and clinical significance of borderline personality disorder, its treatment remains understudied.To evaluate with variably dosed olanzapine in individuals disorder.In this 12-week randomised, double-blind trial, received (2.5-20 mg/day; n=155) or placebo (n=159) (trial registry: NCT00091650). The primary efficacy measure was baseline to end-point change on Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD) using last-observation-carried-forward...
Motivation: Imaging genetics combines brain imaging and genetic information to identify the relationships between variants activities. When data samples belong different classes (e.g. disease status), may exhibit class-specific patterns that can be used facilitate understanding of a disease. Conventional approaches often perform separate analysis on each class report differences, but ignore important shared patterns. Results: In this paper, we develop multivariate method analyze differential...
This study aims to extend previous research by considering gender differences in borderline personality (BPD) using both dimensional self-reported and clinical measures of symptomatology. Drawing from a cross-cultural, trial sample, the authors compared female male BPD subjects (N = 770; 211 male) between ages 18 65 diagnostic self-report data. The found that women with have greater hostility relationship disruption than men. Gender eating disorders, particularly bulimia, are more divergent...