A5060993417- Asthma and respiratory diseases
- Bipolar Disorder and Treatment
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Pharmaceutical studies and practices
- Cannabis and Cannabinoid Research
- Schizophrenia research and treatment
- Emergency and Acute Care Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- School Health and Nursing Education
- Electrolyte and hormonal disorders
- Lung Cancer Diagnosis and Treatment
- Eosinophilic Esophagitis
- Lung Cancer Treatments and Mutations
- Electroconvulsive Therapy Studies
- Prenatal Substance Exposure Effects
- Pulmonary Hypertension Research and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Pediatric health and respiratory diseases
- Hormonal Regulation and Hypertension
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cytomegalovirus and herpesvirus research
- Muscle activation and electromyography studies
- Gastroesophageal reflux and treatments
- Muscle Physiology and Disorders
Hospital Clínic de Barcelona
2023-2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2023-2025
Universitat de Barcelona
2023-2025
Centro de Investigación Biomédica en Red de Salud Mental
2023-2024
Complejo Hospitalario Universitario de Santiago
2023
Servicio Gallego de Salud
2023
Complexo Hospitalario Universitario A Coruña
2023
Hospital Clínico San Carlos
2023
University Hospital Complex Of Vigo
2023
Instituto de Salud Carlos III
2023
In a multicenter, randomized, double-blind study, we compared the effects of nebulized (5 mg x 2) and intravenous (0.5 mg) albuterol (salbutamol) over 1 h in 47 patients admitted to hospital with severe acute asthma defined as peak expiratory flow (PEF) below 150 L/min hypercapnia (Pa(CO2) > or = 40 mm Hg). Additional treatment included nasal oxygen hydrocortisone succinate. The efficacy was assessed after h. group treated by nebulization (NEB group, n 22) 19 (86%) (95% confidence interval:...
Abstract Background Bipolar disorder (BD) is a chronic and recurrent disease characterized by acute mood episodes periods of euthymia. The available literature postulates that biphasic dysregulation mitochondrial bioenergetics might underpin the neurobiology BD. However, most studies focused on inter‐subject differences rather than intra‐subject variations between different states. To test this hypothesis, in preliminary proof‐of‐concept study, we measured vivo respiration patients with BD...
ABSTRACT Introduction Bipolar disorder (BD) is a chronic and recurrent psychiatric illness characterized by alternating episodes of mania and/or hypomania depression. The endocannabinoid system (ECS) vast network chemical signals cellular receptors that are densely packed throughout the brain. It involved in most critical central nervous functions, such as learning memory, also mood regulation. Despite this, there only anecdotal evidence on potential role ECS pathophysiology BD. Objectives...
It has been suggested that pulmonary artery pressure at the end of ejection is close to mean pressure, thus contributing optimization external power from right ventricle. We tested hypothesis dicrotic notch and pressures could be similar magnitude in 15 men (50 +/- 12 yr) referred our laboratory for diagnostic left heart catheterization. Beat-to-beat relationships between were studied 1) rest over 10 consecutive beats 2) 5 patients during Valsalva maneuver (178 studied). At rest, there was...
The aim of the study was to determine whether nonspecific in vivo airway hyperresponsiveness inbred Fisher F‐344 rat strain associated with differences intrinsic contractile properties tracheal smooth muscle (TSM) when compared Lewis rats. Isotonic and isometric isolated TSM from rats (each n=10) were investigated, myosin crossbridge (CB) number, force kinetics both strains calculated using Huxley's equations adapted nonsarcomeric muscles. Maximum unloaded shortening velocity maximum extent...
Emotional intelligence (EI) and neurocognition (NC) impairments are common in first-episode psychosis (FEP), yet their evolution over time remains unclear. This study identified patient profiles EI NC performance FEP. 98 adult FEP patients 128 healthy controls (HCs) were tested on clinical, functional, EI, variables at baseline two-year follow-up (FUP). A repeated-measures ANOVA compared the effects of group (patients HCs) EI. Significant improvements observed both groups. Four groups...
Determinants of the isometric relaxation rate were investigated in isolated rat diaphragm (n = 30). We tested hypothesis that these determinants could include loading conditions, namely preload and afterload; abrupt changes load during contraction phase; stimulation conditions; time. Two sequences studied. When occurred at initial muscle length (isotonic-isometric sequence), an increase total (P) accelerated negative peak tension decline (-dP/dtmax). Variations length, stimulation, onset did...
To analyze the kinetics and unitary force of cross bridges (CBs) in airway smooth muscle (ASM), we proposed a new formalism Huxley's equations adapted to nonsarcomeric muscles (Huxley AF. Prog Biophys Chem7: 255–318, 1957). These were applied ASM from rabbits, rats, humans ( n = 12/group). We tested hypothesis that species differences whole mechanics related CB mechanics. calculated total number per square millimeter at peak isometric tension (Ψ ×10 9 ), (Π), rate constants for attachment f...
The load dependence (LD) of relaxation was studied in the diaphragm rabbits with congestive heart failure (CHF). CHF ( n = 15) induced by combined chronic volume and pressure overload. Aortic insufficiency forcing a catheter through aortic sigmoid valves, followed 3 wk later abdominal stenosis. Six weeks after first intervention, animals developed CHF. Sham-operated served as controls (C; 12). Diaphragm mechanics were vitro on isolated strips, at 22°C, isotonic isometric loading conditions....
Psychiatric comorbidity is common in cancer patients, emphasizing the need for comprehensive care. While depressive symptoms pancreatic have been studied, there limited attention given to manic symptoms. This case report aims contribute knowledge of psychiatric comorbidities by describing a patient with stage IV who presented sudden onset episode. The patient, 61-year-old male cancer, at Emergency Room abrupt behavioural changes suggestive episode 2 weeks evolution. had undergoing...
A patient with drug induced alveolitis due to an antidepressant drug, nomifensine, is described. After inadvertent rechallenge by the sequential bronchoalveolar lavage was carried out. Twenty four hours after fluid contained a high cell count neutrophils predominating. Seven days challenge cells were predominantly lymphocytes.