A5064810007- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- Obsessive-Compulsive Spectrum Disorders
- Mental Health Research Topics
- Suicide and Self-Harm Studies
- Functional Brain Connectivity Studies
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Psychosomatic Disorders and Their Treatments
- Autism Spectrum Disorder Research
- Mental Health and Psychiatry
- Cannabis and Cannabinoid Research
- Attention Deficit Hyperactivity Disorder
- Smoking Behavior and Cessation
- Treatment of Major Depression
- Healthcare Decision-Making and Restraints
- Nerve injury and regeneration
- Homicide, Infanticide, and Child Abuse
- Cardiac Health and Mental Health
- Genetic Associations and Epidemiology
- Neuroscience and Neuropharmacology Research
- Pharmaceutical studies and practices
- Personality Disorders and Psychopathology
- Psychiatric care and mental health services
Parc de Salut
2014-2025
Hospital Del Mar
2014-2024
Hospital del Mar Research Institute
2015-2024
Centro de Investigación Biomédica en Red de Salud Mental
2015-2024
Universitat Autònoma de Barcelona
2004-2024
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2024
Instituto de Salud Carlos III
2024
Universitat Pompeu Fabra
2024
Hospital Universitari Germans Trias i Pujol
2024
Instituto de Neurociencias
2023
Abstract To assess the role of age (early onset psychosis-EOP < 18 years vs. adult psychosis-AOP) and diagnosis (schizophrenia spectrum disorders-SSD bipolar disorders-BD) on duration untreated psychosis (DUP) prodromal symptoms in a sample patients with first episode psychosis. 331 (7–35 old) were recruited 174 (52.6%) diagnosed SSD or BD at one-year follow-up through multicenter longitudinal study. The Symptom Onset Schizophrenia (SOS) inventory, Positive Negative Syndrome Scale...
Clozapine is often underused due to concerns about adverse drug reactions (ADRs) but studies into their prevalences are inconclusive. We therefore comprehensively examined of clozapine-associated ADRs in individuals with schizophrenia and demographic clinical factors associated occurrence. Data from a multi-center study (n=698 participants) were collected. The mean number during clozapine treatment was 4.8, 2.4% participants reporting no ADRs. most common hypersalivation (74.6%), weight gain...
Clozapine is highly effective for treatment-resistant schizophrenia but underutilized due to patient and clinician-related concerns. Little known about the general level of satisfaction with clozapine determinants thereof. We therefore explored in individuals diagnosed spectrum disorders (SSDs). Cross-sectional data from 480 users were used examine demographic clinical factors, including symptom severity, treatment response, adverse drug reactions (ADRs). Patient was self-rated on a scale 1...
Although there is scientific evidence of the presence immunometabolic alterations in major depression, not all patients present them. Recent studies point to association between an inflammatory phenotype and certain clinical symptoms with depression. The objective our study was classify depression disorder using supervised learning algorithms or machine learning, based on oxidative stress biomarkers lifestyle habits.
Little is known about genetic predisposition to relapse. Previous studies have linked cognitive and psychopathological (mainly schizophrenia bipolar disorder) polygenic risk scores (PRS) with clinical manifestations of the disease. This study aims explore potential role PRS from major mental disorders cognition on 114 patients recruited in 2EPs Project were included (56 who had not experienced relapse after 3 years enrollment 58 relapsed during 3-year follow-up). for (PRS-SZ), disorder...
Introduction Thyroid hormones play an essential role in hippocampal development, a key structure psychosis. However, the of these first-episode psychosis (FEP) has received limited attention. It been hypothesized that thyroid could cause morphological modifications through upregulation brain-derived neurotrophic factor (BDNF). In this study, we primarily aimed to determine relationship between thyroid-stimulating hormone (TSH) levels, peripheral BDNF and volume antipsychotic-naïve FEP...
Clinical intervention in early stages of psychotic disorders is crucial for the prevention severe symptomatology trajectories and poor outcomes. Genetic variability studied as a promising modulator prognosis, thus novel approaches considering polygenic nature these complex phenotypes are required to unravel mechanisms underlying progression disorder.The sample comprised 233 first-episode psychosis (FEP) subjects with clinical cognitive data assessed periodically 2-year period 150 matched...
Introduction: Negative symptoms (NS) include asociality, avolition, anhedonia, alogia, and blunted affect are linked to poor prognosis. It has been suggested that they reflect two different factors: diminished expression (EXP) (blunted alogia) amotivation/pleasure (MAP) (anhedonia, asociality). The aim of this article was examine potential sex differences among first-episode schizophrenia (FES) patients analyze sex-related predictors NS factors (EXP MAP) functional outcome. Material Methods:...
A multicentre, non-randomised, open-label study assessed whether personal distress caused by erectile dysfunction (ED) affected psychosocial outcomes of tadalafil treatment. Eligible Swedish men at least 18 years old reporting ≥3-month history ED were stratified into two groups (manifest or mild/no distress) based upon a question administered enrolment. Tadalafil 20 mg was taken as needed for 8 weeks. The primary outcome the difference between in change from baseline Psychological and...
Emotional intelligence (EI) and neurocognition (NC) impairments are common in first-episode psychosis (FEP), yet their evolution over time remains unclear. This study identified patient profiles EI NC performance FEP. 98 adult FEP patients 128 healthy controls (HCs) were tested on clinical, functional, EI, variables at baseline two-year follow-up (FUP). A repeated-measures ANOVA compared the effects of group (patients HCs) EI. Significant improvements observed both groups. Four groups...
There is high prevalence of cigarette smoking in individuals with first-episode psychosis (FEP) prior to onset. The purpose the study was determine impact previous tobacco use or without cannabis on first psychotic experiences FEP and this age onset symptoms, including prodromes. Retrospective analyses from naturalistic, longitudinal, multicentre, "Phenotype-Genotype Environmental Interaction. Application a Predictive Model First Psychotic Episodes (PEPs)" Study. authors analysed...