A5100604467- Schizophrenia research and treatment
- Genetic Associations and Epidemiology
- Obsessive-Compulsive Spectrum Disorders
- Tryptophan and brain disorders
- Bipolar Disorder and Treatment
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Diet and metabolism studies
- Autism Spectrum Disorder Research
- Epigenetics and DNA Methylation
- Genetic factors in colorectal cancer
- Genetics and Neurodevelopmental Disorders
- COVID-19 Clinical Research Studies
- Metabolism and Genetic Disorders
- Adolescent and Pediatric Healthcare
- Attention Deficit Hyperactivity Disorder
- Child and Adolescent Psychosocial and Emotional Development
- Birth, Development, and Health
- Advanced Neuroimaging Techniques and Applications
- Neurotransmitter Receptor Influence on Behavior
- Long-Term Effects of COVID-19
- Colorectal Cancer Screening and Detection
- Functional Brain Connectivity Studies
- Neuroendocrine regulation and behavior
- Mental Health Research Topics
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2017-2025
Universitat de Barcelona
2016-2025
Centro de Investigación Biomédica en Red de Salud Mental
2017-2025
Instituto de Salud Carlos III
2023-2025
Hospital Sant Joan de Déu Barcelona
2024
Hospital of the University of Pennsylvania
2023
Research Institute Hospital 12 de Octubre
2017-2023
Universidad Complutense de Madrid
2020-2023
Central University of the Caribbean
2023
BioCruces Health research Institute
2023
Insulin causes endothelium-derived nitric oxide (NO)-dependent vascular relaxation, and increases L-arginine transport via cationic amino acid transporter 1 (hCAT-1) endothelial NO synthase (eNOS) expression activity in human umbilical vein endothelium (HUVEC). We studied insulin effect on SLC7A1 gene hCAT-transport role insulin-modulated fetal reactivity. HUVEC were used for L-[(3) H]citrulline formation (NOS activity) assays absence or presence of N-ethylmaleimide (NEM) L-lysine...
Although the exact etiology of obsessive-compulsive disorder (OCD) is unknown, there growing evidence a role for immune dysregulation in pathophysiology disease, especially innate system including microglia. To test this hypothesis, we studied inflammatory markers monocytes from pediatric patients with OCD and healthy controls. We determined percentages total monocytes, CD16+ classical (CD14highCD16−), intermediate (CD14highCD16low), non-classical (CD14lowCD16high) monocyte subsets 102...
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Schizophrenia and bipolar disorder exhibit substantial clinical overlap, particularly in individuals at familial high risk, who frequently present sub-threshold symptoms before the onset of illness. Severe mental disorders are highly polygenic traits, but their impact on stages preceding manifestation remains relatively unexplored. Our study aimed to examine influence risk scores (PRS) sub-clinical outcomes over a 2-year period youth for schizophrenia controls. The sample included 222...
Patients with chronic pain often lack the skills and resources necessary to manage this disease. To develop a self-management program reflecting community stakeholders' priorities compare functional outcomes from training in two settings. A parallel-group randomized trial. Eligible subjects were 35–70 years of age, non-cancer treated opioids for >2 months at primary care one HIV clinic serving low-income Hispanics. In study arm, 6-month was delivered monthly one-on-one meetings by health...
Abstract Psychiatry lags in adopting etiological approaches to diagnosis, prognosis, and outcome prediction compared the rest of medicine. Etiological factors such as childhood trauma (CHT), substance use (SU), socioeconomic status (SES) significantly affect psychotic disorder symptoms. This study applied an agnostic clustering approach identify exposome clusters “Exposotypes (ETs)” examine their relationship with clinical, cognitive, functional outcomes. Using data from individuals...
Abstract Epigenetic modifications occur sequentially during the lifespan, but their pace can be altered by external stimuli. The onset of schizophrenia and bipolar disorder is critically modulated stressors that may alter epigenetic pattern, a putative signature marker exposure to environmental risk factors. In this study, we estimated age-related assess differences between young individuals at familial high (FHR) controls association with stressors. sample included 117 (6–17 years) FHR...
Abstract In previous work we developed a pharmacogenetic predictor of antipsychotic (AP) induced extrapyramidal symptoms (EPS) based on four genes involved in mTOR regulation. The main objective is to improve this by increasing its biological plausibility and replication. We re-sequence the using next-generation sequencing. predict functionality “in silico” all identified SNPs test it gene reporter assays. Using functional SNPs, develop new utilizing machine learning algorithms (Discovery...
One of the leading biological models obsessive-compulsive disorder (OCD) is frontal-striatal-thalamic model. This study undertakes an extensive exploration variability in genes related to regulation system a sample early-onset OCD trios. To this end, we genotyped 266 single nucleotide polymorphisms (SNPs) 35 84 probands and their parents. Finally, 75 complete trios were included analysis. Twenty SNPs overtransmitted from parents presented nominal pointwise P < 0.05 values. Three these...
Objective: The exact aetiology of obsessive-compulsive disorder (OCD) is unknown, although there evidence to suggest a gene–environment interaction model. Several lines support possible role the immune system in this model.Methods: present study explores allele variability HLA genes class II (HLA-DRB1, HLA-DQB1) sample 144 early-onset OCD compared with reference samples general population same geographical area.Results: None 39 alleles identified (allele frequency >1%) showed significant...
Background We evaluate the association between Trypanosoma cruzi infection and strongyloidiasis in a cohort of Latin American (LA) migrants screened for both infections non-endemic setting. Methodology Case-control study including LA individuals who were systematically T. January 2013 April 2015. Individuals included as cases if they had positive serological result Strongyloides stercoralis. Controls randomly selected from that tested negative S. stercoralis serology. The was evaluated by...
The natural flow regime is a key regulator of the dynamics stream communities and ecosystem processes. Native fish assemblages are evolutionarily adapted to their local regime. In Caribbean, streams vulnerable changes in climate that will alter regimes. We assessed long-term patterns (2008-2016) an urban San Juan, Puerto Rico. hypothesized drought periods would result negative effects on native species positive introduced species. Fish were sampled annually from 2008 2016 by backpack...
Abstract Dexamethasone and tocilizumab have been associated with reduction in mortality, however, the beneficial effect is not for all patients impact on viral replication well defined. We hypostatized that C-reactive protein (CRP) could help identification of requiring anti-inflammatory therapy. Patients admitted > 48 h our hospital a confirmed or suspected infection by SARS-CoV-2 from February 2020 to 2021 were retrospectively evaluated. The primary outcome was mortality at 30 days....
Background: The incidence of sporadic colorectal cancer (CRC) among individuals <50 years (early-onset CRC) has been increasing in the United States (U.S.) and Puerto Rico. CRC is currently leading cause death Hispanic men women living Rico (PRH). objective this study was to characterize molecular markers clinicopathologic features tumors from PRH better understand pathways subpopulation. Methods: Microsatellite instability (MSI), CpG island methylator phenotype (CIMP), KRAS BRAF mutation...
Little is known about genetic predisposition to relapse. Previous studies have linked cognitive and psychopathological (mainly schizophrenia bipolar disorder) polygenic risk scores (PRS) with clinical manifestations of the disease. This study aims explore potential role PRS from major mental disorders cognition on 114 patients recruited in 2EPs Project were included (56 who had not experienced relapse after 3 years enrollment 58 relapsed during 3-year follow-up). for (PRS-SZ), disorder...