A5021718985- Malaria Research and Control
- Mosquito-borne diseases and control
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Infective Endocarditis Diagnosis and Management
- Hemoglobinopathies and Related Disorders
- Pneumonia and Respiratory Infections
- Bacterial Identification and Susceptibility Testing
- Antibiotic Resistance in Bacteria
- Respiratory viral infections research
- Vibrio bacteria research studies
- Antimicrobial Resistance in Staphylococcus
- Food Allergy and Anaphylaxis Research
- COVID-19 Clinical Research Studies
- Streptococcal Infections and Treatments
- Complement system in diseases
- Neonatal and Maternal Infections
- Microscopic Colitis
- Bacterial Infections and Vaccines
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 detection and testing
- Iron Metabolism and Disorders
- Gastrointestinal motility and disorders
- Bacterial biofilms and quorum sensing
- Nosocomial Infections in ICU
Instituto de Salud Carlos III
2023-2025
Centro de Investigación Biomédica en Red
2023-2025
Universitat de Barcelona
1997-2025
Barcelona Institute for Global Health
2018-2025
DNA Diagnostic (Denmark)
2025
Departament de Salut
2024-2025
Hospital Clínic de Barcelona
1997-2025
Centro de Investigación en Red en Enfermedades Cardiovasculares
2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
1999-2025
Centre for Human Genetics
2010-2021
ABSTRACT Pseudomonas aeruginosa is an opportunistic pathogen capable of causing severe infections in immunocompromised individuals, who often require prolonged antibiotic therapy. The emergence carbapenemase-producing P. has further complicated the management nosocomial infections, limiting therapeutic options. Cefiderocol recently emerged as a promising antipseudomonal agent, using bacterial iron transport system to gain entry into cell; however, there have been reports resistant...
Time to positivity (TTP) and differential TTP (DTP) emerge as diagnostic prognostic tools for bloodstream infections (BSI) though specific cut-off values need be determined each pathogen. Pseudomonas aeruginosa BSI (PAE-BSI) is of critical concern, particularly in immunocompromised patients, due high mortality rates. Catheter-related are a common cause, necessitating rapid accurate effective management (source-control). Unicentric retrospective observational study analyzing the utility best...
Background. Infection is a major complication after total joint arthroplasty. The urinary tract possible source of surgical site contamination, but the role asymptomatic bacteriuria (ASB) before elective surgery and subsequent risk infection poorly understood.
A substantial decline in malaria was reported to have occurred over several years until 2007 the western part of The Gambia, encouraging consideration future elimination this previously highly endemic region. Scale up interventions has since increased with support from Global Fund and other donors.We continued examine laboratory records at four health facilities studied investigated six additional for a 7 year period, adding data 243,707 slide examinations, determine trends throughout...
The COVID-19 pandemic has greatly impacted the daily clinical practice of cardiologists and cardiovascular surgeons. Preparedness health workers services is crucial to tackle enormous challenge posed by SARS-CoV-2 in wards, operating theatres, intensive care units, interventionist laboratories. This Clinical Review provides an overview focuses on relevant aspects prevention management for specialists within field.
Human genetic factors are important determinants of malaria risk. We investigated associations between multiple candidate polymorphisms-many related to the structure or function red blood cells-and risk for severe Plasmodium falciparum and its specific phenotypes, including cerebral malaria, anaemia, respiratory distress.
A total of 451 stool specimens were collected from children less than five years age with acute diarrhea Ifakara, Tanzania and processed to detect bacterial enteropathogens, parasites, rotaviruses. These divided into 348 the dry season 103 rainy season. Overall, diarrheogenic Escherichia coli (35.7%) predominant enterotoxigenic E. coli, enteroaggregative enteropathogenic being most prevalent. Moreover, (63% versus 35.5%; P < 0.05), Shigella spp. (24% 12%; rotavirus (23% 4%; 0.05) more...
Reche M, Pascual C, Fiandor A, Polanco I, Rivero-Urgell Chifre R, Johnston S, Martín-Esteban M. The effect of a partially hydrolysed formula based on rice protein in the treatment infants with cow’s milk allergy.Pediatr Allergy Immunol 2010: 21: 577–585.© 2010 John Wiley & Sons A/S Infants diagnosed allergy to (CMP) are fed extensively formulas, modified soy formulas or even amino acid-based formulas. Hydrolysed infant have become available and been shown be well tolerated by these infants....
To cite this article: Keil T, McBride D, Grimshaw K, Niggemann B, Xepapadaki P, Zannikos Sigurdardottir ST, Clausen M, Reche Pascual C, Stanczyk AP, Kowalski ML, Dubakiene R, Drasutiene G, Roberts Schoemaker A‐FA, Sprikkelman AB, Fiocchi A, Martelli Dufour S, Hourihane J, Kulig Wjst Yazdanbakhsh Szépfalusi Z, van Ree Willich SN, Wahn U, Mills ENC, Beyer K. The multinational birth cohort of EuroPrevall: background, aims and methods. Allergy 2010; 65 : 482–490. Abstract Background/aim: true...
Cerebral malaria (CM) in children is associated with a high mortality and long-term neurocognitive sequelae. Both erythropoietin (Epo) vascular endothelial growth factor (VEGF) have been shown to be neuroprotective. We hypothesized that plasma cerebrospinal fluid (CSF) levels of these cytokines would prevent neurological sequelae CM. measured Epo, VEGF, tumor necrosis paired samples CSF Kenyan admitted Logistic regression models were used identify risk protective factors the development...
To assess management patterns and outcome in patients with glioblastoma multiforme (GBM) treated during 2008–2010 Spain. Retrospective analysis of clinical, therapeutic, survival data collected through filled questionnaires from histologically confirmed GBM diagnosed 19 Spanish hospitals. We identified 834 (23% aged >70 years). Surgical resection was achieved 66% patients, although the extent surgery by postoperative MRI only 41%. There were major complications 14% age independent predictor...
The intestinal commensal microbiota provides a myriad of benefits to the healthy host, including colonisation resistance against pathogens. Perturbations (dysbiosis) may adversely affect health status an individual and prevent protection colonisation. whole range antibiotic genes (resistome) in specific is found pathogenic non-pathogenic bacteria. administration antibiotics cause dysbiosis, contributing loss followed by increment resistome microbiota. Treatments control current increase...
Background: The limited diagnostic accuracy of biomarkers in children at risk a serious bacterial infection (SBI) might be due to the imperfect reference standard SBI. We aimed evaluate performance new classification algorithm for biomarker discovery Methods: used data from five previously published, prospective observational studies, which included patients aged 0– &lt;16 years: Alder Hey emergency department ( n = 1,120), pediatric intensive care unit 355), Erasmus 1,993), Maasstad...
Differentiating between self-resolving viral infections and bacterial in children who are febrile is a common challenge, causing difficulties identifying which individuals require antibiotics. Studying the host response to infection can provide useful insights lead identification of biomarkers with diagnostic potential. This study aimed identify protein for future development into an accurate, rapid point-of-care test that distinguish infections, by recruiting presenting health-care settings...
Antiretroviral therapy has improved life expectancy in HIV-infected patients. However, people living with HIV under antiretroviral are at higher risks of developing chronic complications and acquiring multidrug resistant bacteria than healthy population. These factors have been associated shifts gut microbiome composition immune activation. It is unclear how drugs affect microbiota composition, but it observed that treatment not able to fully restore health after infection. Additionally,...
The rapid and broad microbiological diagnosis of meningoencephalitis (ME) has been possible thanks to the development multiplex PCR tests applied cerebrospinal fluid (CSF). We aimed assess a new panel (the QIAstat-Dx ME panel), which we compared conventional diagnostic tools Biofire FilmArray Panel. pathogens analyzed using both methods were Escherichia coli K1, Haemophilus influenzae, Listeria monocytogenes, Neisseria meningitidis, Streptococcus agalactiae, pneumoniae, Enterovirus, herpes...
Abstract Introduction Alterations in microbiota composition have been implicated a variety of human diseases. Patients with adenomyosis present immune dysregulation leading to persistent chronic inflammatory response. In this context, the hypothesis that alterations may be involved pathogenesis adenomyosis, by affecting epigenetic, immunologic, and biochemical functions host, has recently postulated. The aim study was compare vagina, endometrium, gut individuals without adenomyosis. Material...
ABSTRACT A matched case-control study was conducted in the Maternal and Child Health Clinic (MCH) Ifakara, Tanzania, during rainy season order to elucidate risk factors for etiology of diarrheal diseases children under 5 years age. Cases (103) controls (206) were sex age group. Precoded questionnaires with demographic details, clinical history, physical signs completed. Stools samples collected bacterial, parasitological, viral studies. high number siblings (odds ratio [OR], 0.86; P =...