A5041113460- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Neutropenia and Cancer Infections
- Bacterial Identification and Susceptibility Testing
- HIV/AIDS Research and Interventions
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Antibiotic Use and Resistance
- SARS-CoV-2 and COVID-19 Research
- Dental Research and COVID-19
- Antimicrobial Resistance in Staphylococcus
- Artificial Intelligence in Healthcare and Education
- Antibiotic Resistance in Bacteria
- HIV-related health complications and treatments
- Infectious Encephalopathies and Encephalitis
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 diagnosis using AI
- Edible Oils Quality and Analysis
- HIV, Drug Use, Sexual Risk
- Pneumonia and Respiratory Infections
- Inflammatory Biomarkers in Disease Prognosis
- Plant Pathogens and Fungal Diseases
- Mosquito-borne diseases and control
Complejo Hospitalario de Navarra
2022-2023
Universidad de Alcalá
2023
Instituto de Salud Carlos III
2023
Instituto Ramón y Cajal de Investigación Sanitaria
2023
Universidad de Navarra
2023
Hospital Clínic de Barcelona
2019-2022
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2019-2022
Universitat de Barcelona
2019-2022
Abstract Background We aimed to describe the current rates of inappropriate empirical antibiotic treatment (IEAT) in oncohematological patients with febrile neutropenia (FN) and its impact on mortality. Methods This was a multicenter prospective study all episodes bloodstream infection (BSI) high-risk FN (2006–2017). Episodes receiving IEAT were compared appropriate therapy. Adherence Infectious Diseases Society America (IDSA) recommendations evaluated. Multivariate analysis performed...
BackgroundCalcium is an essential ion for pathogen survival and virulence involved in the regulation of inflammatory response. Hypocalcemia a common laboratory finding critically ill patients. Data regarding levels calcium SARS-CoV-2 infection scarce. Patients with who present hypocalcemia could have worse outcome.MethodsWe performed retrospective analysis hospitalized patients included all had any serum measurement first 72 h since hospital admission. The main objective was to investigate...
Abstract Hospitalized patients with coronavirus disease 2019 (COVID-19) experiencing respiratory symptoms have different complications (inflammatory, co-infection, and thrombotic) that are identifiable by analytics patterns. Personalized treatment decisions decreased early mortality (odds ratio [OR] .144; 95% confidence interval [CI] .03–.686; P = .015). Increasing age (OR 1.06; .038) therapeutic effort limitation 9.684; < .001) were associated higher mortality.
Abstract Background In some patients the immune response triggered by SARS-CoV-2 is unbalanced, presenting an acute respiratory distress syndrome which in many cases requires intensive care unit (ICU) admission. The limitation of ICU beds has been one major burdens management worldwide; therefore, clinical strategies to avoid admission are needed. Objective We aimed describe influence tocilizumab on need transfer or death non-critically ill patients. Methods A retrospective study 171 with...
Background We aimed to describe the epidemiology of catheter-related bloodstream infections (CRBSIs) in onco-hematological neutropenic patients during a 25-year study period, evaluate risk factors for Gram-negative bacilli (GNB) CRBSI, as well rates inappropriate empirical antibiotic treatments (IEAT) and mortality. Materials/Methods All consecutive episodes CRBSIs were prospectively collected (1994–2018). Changing was evaluated comparing five-year time spans. A multivariate regression model...
Objectives. In some patients the immune response triggered by SARS-CoV-2 is unbalanced, presenting an acute respiratory distress syndrome which in many cases requires intensive care unit (ICU) admission. The limitation of ICU beds has been one major burdens management around world; therefore, clinical strategies to avoid admission are needed. We aimed describe influence tocilizumab on need transfer or death non-critically ill patients. Material and methods. A retrospective study 171 with...
There are no clear criteria for antifungal de-escalation after initial empirical treatments. We hypothesized that early (ED) (within 5 days) to fluconazole is safe in fluconazole-susceptible candidemia with controlled source of infection. This a multicenter post hoc study included consecutive patients from 3 prospective cohorts (2007-2016). The impact ED and factors associated mortality were assessed. Of 1023 episodes, 235 met inclusion criteria. these, 54 (23%) classified as the group 181...
In recent years, important epidemiologic changes have been described in hematopoietic stem cell transplantation (HSCT) recipients with bloodstream infection (BSI), increases gram-negative bacilli and multidrug resistant (MDR) bacilli. These linked to a worrisome increase mortality. We aimed define the risk factors for mortality of HSCT patients experiencing BSI. All episodes BSI between 2008 2017 were prospectively collected. Multivariate analyses performed. A total 402 documented 293 who...
Dolutegravir (DTG) based dual therapies for treating PLWHIV are a standard of care nowadays. Switching to DTG and lamivudine (3TC) safety efficacy were proven in TANGO randomized clinical trial. This multicenter retrospective study included 1032 HIV virologically suppressed patients switching DTG+3TC from 13 Spanish hospitals. provided high rates undetectable viral load over 96%, corresponding 96.6% (889/921) at 24 weeks, 97.5% (743/763) 48 98.3% (417/425) 96 weeks. No significant...
Switching dual therapy with dolutegravir (DTG) plus rilpivirine (RPV) was assessed in the SWORD-1 and SWORD-2 studies. Real-life data regarding immunological impact of this approach on CD4+ CD8+ T lymphocyte counts CD4/CD8 ratio are scarce. We evaluated strategy basis clinical practice data.A multicentric retrospective cohort study.Treatment-experienced virologically suppressed HIV-1-infected patients who were switched to DTG RPV included. Using different models for paired data, we efficacy...
We estimated the incidence rate of HIV medical care interruption (MCI) and its evolution over a 16-year-period, identified associated risk factors among HIV-positive individuals from Cohort Spanish AIDS Research Network in 2004-2020.We included antiretroviral-naive aged at least 18 years enrolment, recruited between January 1, 2004, August 30, 2019, followed-up until November 2020.Individuals with any time interval 15 months two visits were defined as having MCI. calculated (IR) one MCI used...
The study aims to describe characteristics and clinical outcome of patients with SARS-CoV-2 infection that received siltuximab according a protocol aimed early block the activity IL-6 avoid progression inflammatory flare.Retrospective review first 31 treated siltuximab, in Hospital Clinic Barcelona or Universitario Salamanca, from March April 2020 positive polymerase-chain reaction (PCR) nasopharyngeal swab.The cohort included cases median (IQR) age 62 (56-71) 71% were males. most frequent...
Abstract The objective of this study was to assess the performance direct real time RT-PCR detection SARS-CoV-2 in heated saliva samples, avoiding RNA isolation step. Oropharyngeal and nasopharyngeal swabs together with samples were obtained from 51 patients clinically diagnosed as potentially having COVID-19. Two different methods compared: 1. extracted 500 μl sample using a MagNA Pure Compact Instrument an elution volume 50μl 2. 700µL heat-inactivated at 96°C for 15 minutes, directly...
The study aim was to assess the influence of inflammatory response modifiers, including anti-interleukin-6 (IL-6) biologics and corticosteroids, on incidence hospital-acquired infections in patients with coronavirus disease 2019 (COVID-19). Case–control performed at a university hospital from February 26 May 26, 2020. Cases were defined as COVID-19 who developed infections. For each case, two controls selected among without matched obeying three criteria hierarchical sequence: length stay up...
Background We monitored the quality of care for newly diagnosed people with HIV (PWH) in Spain, including linkage to within 1 month diagnosis (LC-1Mo) and viral suppression 3 months (VS-3Mo). Methods Longitudinal study based on The Cohort Spanish AIDS Research Network (CoRIS). used logistic regression stratified by year (2004–2013 2014–2019) assess differences sex, country origin, risk group, age, prior AIDS, Viral Load, CD4 cell count. Results final analysis included 13,632 PWH: males 85%,...