A5070097778- Pneumonia and Respiratory Infections
- Nosocomial Infections in ICU
- Respiratory Support and Mechanisms
- Respiratory viral infections research
- Sepsis Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Cystic Fibrosis Research Advances
- Emergency and Acute Care Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- COVID-19 Clinical Research Studies
- Intensive Care Unit Cognitive Disorders
- Long-Term Effects of COVID-19
- Neonatal Respiratory Health Research
- Antibiotic Use and Resistance
- Respiratory and Cough-Related Research
- Tracheal and airway disorders
- Pediatric health and respiratory diseases
- Antibiotic Resistance in Bacteria
- Influenza Virus Research Studies
- Antimicrobial Resistance in Staphylococcus
- Airway Management and Intubation Techniques
- Tuberculosis Research and Epidemiology
- Hemodynamic Monitoring and Therapy
- Asthma and respiratory diseases
- Antibiotics Pharmacokinetics and Efficacy
Hospital Clínic de Barcelona
2015-2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2016-2025
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2016-2025
Universitat de Barcelona
2016-2025
Instituto de Salud Carlos III
2018-2025
Fundació Clínic per a la Recerca Biomèdica
2017-2022
Centro de Investigación Biomédica en Red
2019-2022
Centre for Biomedical Network Research on Rare Diseases
2017-2022
Hospital Universitari i Politècnic La Fe
2021
Biomedical Research Institute
2019-2020
IMPORTANCEIn patients with severe community-acquired pneumonia, treatment failure is associated excessive inflammatory response and worse outcomes.Corticosteroids may modulate cytokine release in these patients, but the benefit of this adjunctive therapy remains controversial.OBJECTIVE To assess effect corticosteroids communityacquired pneumonia high response.DESIGN, SETTING, AND PARTICIPANTS Multicenter, randomized, double-blind, placebo-controlled trial conducted 3 Spanish teaching...
<h3>Background</h3> The distribution of the microbial aetiology and mortality community-acquired pneumonia (CAP) was investigated in relation to clinical setting severity scores (pneumonia index (PSI) confusion, blood urea nitrogen, respiratory rate, pressure, age (CURB-65)). <h3>Methods</h3> 3523 patients with CAP were included (15% outpatients, 85% inpatients). (PSI, CURB-65) relative different aetiologies across analysed. <h3>Results</h3> established 1463 (42%), whom 257 died (7%)....
Rationale: The Sepsis-3 Task Force updated the clinical criteria for sepsis, excluding need systemic inflammatory response syndrome (SIRS) criteria. implications of proposed flowchart including quick Sequential (Sepsis-related) Organ Failure Assessment (qSOFA) and SOFA scores are unknown.Objectives: To perform a decision-making analysis in patients with community-acquired pneumonia.Methods: This was cohort study adult pneumonia from two Spanish university hospitals. SIRS, qSOFA, Confusion,...
Background Patients with severe community-acquired pneumonia (SCAP) and life-threatening acute respiratory failure may require invasive mechanical ventilation (IMV). Since use of IMV is often associated significant morbidity mortality, we assessed whether patients invasively ventilated would represent a target population for interventions aimed at reducing mortality SCAP. Methods We prospectively recruited consecutive SCAP 12 years. the characteristics outcomes presentation pneumonia,...
Abstract Introduction The frequency and clinical significance of polymicrobial aetiology in community-acquired pneumonia (CAP) patients admitted to the ICU have been poorly studied. aim present study was describe prevalence, characteristics outcomes severe CAP ICU. Methods prospective observational included 362 consecutive adult with within 24 hours presentation; 196 (54%) had an established aetiology. Results Polymicrobial infection 39 (11%) cases (20% those defined aetiology): 33 two...
<b><i>Background:</i></b> It is crucial to identify risk factors for poor evolution of patients admitted hospital with chronic obstructive pulmonary disease (COPD) in order provide adequate intensive therapy and closer follow-up. <b><i>Objectives:</i></b> To predictors adverse outcomes hospitalised exacerbation COPD. <b><i>Methods:</i></b> A prospective, observational study was conducted Demographic clinical parameters...
Bacterial co-infection is an important contributor to morbidity and mortality during influenza pandemics .We investigated the incidence, risk factors outcome of patients with A H1N1 pneumonia bacterial co-infection.Prospective observational study consecutive hospitalized virus community-acquired (CAP). We compared cases without co-infection.The incidence infection in CAP pandemic period was 19% (n, 667). studied 128 patients; 42(33%) had co-infection. The most frequently isolated pathogens...
Twenty per cent of chronic obstructive pulmonary disease (COPD) patients are readmitted for acute exacerbation (AECOPD) within 30 days discharge. The prognostic significance early readmission is not fully understood. objective our study was to estimate the mortality risk associated with discharge in COPD patients.The cohort (n = 378) divided into 68) and 310) Clinical, laboratory, microbiological, severity data were evaluated at admission during hospital stay, recorded four time points...
We describe the aetiology of community-acquired pneumonia (CAP) in HIV-infected patients, risk factors for bacterial or Pneumocystis jirovecii CAP and prognostic 30-day mortality. This was a prospective observational study 331 consecutive adult cases patients (January 2007 to July 2012). 128 (39%) had CD4 + cell counts <200 per mm 3 99 (43%) ha HIV RNA levels copies mL on antiretroviral therapy. Streptococcus pneumoniae most frequent microorganism group with ≥200 ; P. mL. Predictors were:...
Our aim was to assess the incidence, characteristics, aetiology, risk factors and mortality of acute respiratory distress syndrome (ARDS) in intensive care unit (ICU) patients with community-acquired pneumonia (CAP) using Berlin definition. We prospectively enrolled consecutive mechanically ventilated adult ICU CAP over 20 years, compared them without ARDS. The main outcome 30-day mortality. Among 5334 hospitalised CAP, 930 (17%) were admitted 432 required mechanical ventilation; 125 (29%)...
Although the prevalence of community-acquired respiratory bacterial coinfection upon hospital admission in patients with coronavirus disease 2019 (COVID-19) has been reported to be < 5%, almost three-quarters received antibiotics. We aim investigate whether procalcitonin (PCT) or C-reactive protein (CRP) could helpful biomarkers identify among COVID-19 pneumonia. carried out a multicentre, observational cohort study including consecutive admitted 55 Spanish intensive care units (ICUs). The...
The purpose of this study was to establish the microbial aetiology and outcomes patients with community-acquired pneumonia (CAP) treated as outpatients after presenting a hospital emergency care unit. A prospective observational carried out in Hospital Clinic Barcelona (Barcelona, Spain). All consecutive cases CAP were included. 568 adult studied (mean± sd age 47.2±17.6 yrs; 110 (19.4%) aged ≥65 yrs). Aetiological diagnoses established 188 (33.1%) cases. Streptococcus pneumoniae most...
Rationale: There are conflicting reports describing the effect of macrolide resistance on presentation and outcomes patients with Streptococcus pneumoniae pneumonia.Objectives: We aimed to determine pneumococcal pneumonia.Methods: conducted a retrospective, observational study in Hospital Clinic Barcelona all adult hospitalized pneumonia who had positive cultures for S. from January 1, 2000 December 31, 2013. Outcomes examined included bacteremia, pulmonary complications, acute renal...
Rationale: Detection of the C-polysaccharide Streptococcus pneumoniae in urine by an immune-chromatographic test is increasingly used to evaluate patients with community-acquired pneumonia.Objectives: We assessed sensitivity and specificity this largest series cases date logistic regression models determine predictors positivity hospitalized pneumonia.Methods: performed a multicenter, prospective, observational study 4,374 pneumonia.Measurements Main Results: The urinary antigen was done...
ABSTRACT Background and objective Seasonal distribution of microbial aetiology in patients with community‐acquired pneumonia ( CAP ) may add important information both for epidemiologists clinicians. We investigate the seasonal . Methods This prospective observational study was carried out Hospital Clinic Barcelona, Spain (January 2003–December 2014). Results studied 4431 , whom 2689 (61%) were males. Microbial identified 1756 (40%). most frequent winter (34%) but two‐third presented other...
Abstract Background Microbial aetiology of intensive care unit (ICU)-acquired pneumonia (ICUAP) determines antibiotic treatment and outcomes. The impact polymicrobial ICUAP is not extensively known. We therefore investigated the characteristics outcomes ICUAP. Method Patients with confirmed microbiologically were prospectively compared according to identification 1 (monomicrobial) or more (polymicrobial) potentially-pathogenic microorganisms. Microbes usually considered as non-pathogenic for...
<b>Introduction:</b> Treatment failure is associated with excessive inflammatory response and worse outcomes in patients severe community-acquired pneumonia (CAP). However the anti-inflammatory role of corticosteroids these remains controversial. We aimed to investigate effects intravenous methylprednisolone (M-Pred) on treatment CAP. <b>Materials methods:</b> conducted a multicenter, randomized, double-blind, placebo-controlled trial CAP (C-reactive protein >150 mg/L). Of 120 recruited...
We investigated the risk and prognostic factors of pure viral sepsis in adult patients with community-acquired pneumonia (CAP), using Sepsis-3 definition. Pure was found 3% all (138 4028) admitted to emergency department a diagnosis CAP, 19% those CAP 722) intensive care unit, 61% 225) CAP. Our data indicate that males aged ≥65 years are at increased sepsis.