Judith Marín‐Corral
A5044079144- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Pneumonia and Respiratory Infections
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Nosocomial Infections in ICU
- Influenza Virus Research Studies
- Thermal Regulation in Medicine
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Airway Management and Intubation Techniques
- Nutrition and Health in Aging
- Exercise and Physiological Responses
- Cardiovascular and exercise physiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Hemodynamic Monitoring and Therapy
- Clinical Nutrition and Gastroenterology
- Respiratory viral infections research
- Antibiotic Use and Resistance
- Mechanical Circulatory Support Devices
- Machine Learning in Healthcare
- Family and Patient Care in Intensive Care Units
- Tracheal and airway disorders
- COVID-19 diagnosis using AI
Hospital Del Mar
2016-2025
The University of Texas Health Science Center at San Antonio
2020-2024
Hospital del Mar Research Institute
2016-2023
Parc de Salut
2015-2023
South Texas Veterans Health Care System
2023
Universitat Autònoma de Barcelona
2008-2022
Universidad Francisco de Vitoria
2022
Hospital Universitario de Torrejón
2022
Hospital Universitario Príncipe de Asturias
2022
Universidad de Alcalá
2022
Inflammation and oxidative stress contribute to muscle dysfunction in patients with chronic obstructive pulmonary disease (COPD). Oxidants contained cigarette smoke (CS) induce adverse effects on tissues through phenomena.To explore inflammation quadriceps of human smokers diaphragm limb muscles guinea pigs chronically exposed CS.Muscle function, protein oxidation nitration, antioxidants, oxidized proteins, inflammation, creatine kinase activity, lung structures were investigated vastus...
The clinical evolution of COVID-19 pneumonia is poorly understood. Identifying the metabolic pathways that are altered early with viral infection and their association disease severity crucial to understand pathophysiology, guide decisions. This study aimed at assessing critical in hospitalized patients. Forty-nine patients were enrolled a prospective, observational, single-center Barcelona, Spain. Demographic, clinical, analytical data admission registered. Plasma samples collected within...
The identification of factors associated with Intensive Care Unit (ICU) mortality and derived clinical phenotypes in COVID-19 patients could help for a more tailored approach to decision-making that improves prognostic outcomes.Prospective, multicenter, observational study critically ill confirmed disease acute respiratory failure admitted from 63 ICUs Spain. objective was utilize an unsupervised clustering analysis derive analyze patient's risk. Patient features including demographics data...
<h3>Background:</h3> Although exercise training has beneficial effects on skeletal muscle bioenergetics and performance in patients with severe chronic obstructive pulmonary disease (COPD), it may also be associated increased quadriceps oxidative nitrosative stress. The aim of this study was to explore stress COPD, both before after a 3 week endurance programme, identify the nature oxidatively modified proteins. <h3>Methods:</h3> Reactive carbonyls, hydroxynonenal–protein adducts,...
In the diaphragms of chronic obstructive pulmonary disease (COPD) patients, nature oxidatively modified proteins and superoxide anion production were explored. Diaphragm specimens obtained through thoracotomy because localised lung lesions in COPD patients (16 severe eight moderate) 10 control subjects. Lung respiratory muscle functions evaluated. Oxidised identified using immunoblotting mass spectrometry. Protein activity levels determined assays. Lucigenin-derived chemiluminescence signals...
Influenza A (H1N1)pdm09 virus infection acquired in the hospital and critically ill patients admitted to intensive care unit (ICU) has been poorly characterized.To assess clinical impact of hospital-acquired with influenza patients.Analysis a prospective database Spanish registry (2009-2015) severe ICU. Infection was defined as when diagnosis starting treatment occurred from seventh day stay no suspicion on admission, community-acquired established within first 48 h admission.Of 2421...
<h3>BACKGROUND:</h3> Despite wide use of noninvasive ventilation (NIV) in several clinical settings, the beneficial effects NIV patients with hypoxemic acute respiratory failure (ARF) due to influenza infection remain controversial. The aim this study was identify profile risk factors for using chi-square automatic interaction detection (CHAID) analysis and determine whether is associated ICU mortality. <h3>METHODS:</h3> This work a secondary from prospective observational multi-center...
Abstract One of the hallmarks SARS-CoV-2 infection is an induced immune dysregulation, in some cases resulting cytokine storm syndrome and acute respiratory distress (ARDS). Several physiological parameters are altered as a result storm. Among them, microRNAs (miRNAs) might reflect this poor condition since they play significant role cellular performance including inflammatory responses. Circulating miRNAs patients who underwent ARDS needed mechanical ventilation (MV+; n = 15) were analyzed...
Although the prevalence of community-acquired respiratory bacterial coinfection upon hospital admission in patients with coronavirus disease 2019 (COVID-19) has been reported to be < 5%, almost three-quarters received antibiotics. We aim investigate whether procalcitonin (PCT) or C-reactive protein (CRP) could helpful biomarkers identify among COVID-19 pneumonia. carried out a multicentre, observational cohort study including consecutive admitted 55 Spanish intensive care units (ICUs). The...
Discrepancies exist regarding the involvement of cellular inflammation and apoptosis in muscle dysfunction chronic obstructive pulmonary disease (COPD) patients with preserved body composition. We explored whether levels inflammatory cells were increased both respiratory limb muscles COPD without nutritional abnormalities. In vastus lateralis, external intercostals, diaphragms severe moderate normal composition, healthy subjects, intramuscular leukocytes macrophage determined...
In fast- and slow-twitch limb heart muscles of cachectic rats, redox balance muscle structure were explored. The nature the oxidatively modified proteins also was identified in these muscles. Reactive carbonyls, hydroxynonenal (HNE)- malondialdehyde (MDA)-protein adducts, antioxidant enzyme levels determined (7 days after inoculation Yoshida AH-130 ascites hepatoma) control rats. Moreover, carbonylated (proteomics), fiber-type composition evaluated (morphometry) compared with controls: (a)...
Abstract Background Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study investigate associations between mortality and variables measured during first three days ventilation with intubated at ICU admission. Methods Multicenter, observational, cohort includes consecutive admitted 44 Spanish ICUs February 25 July 31, 2020, who required intubation admission for more than days. We collected demographic clinical data prior...
The risk of severe coronavirus disease 2019 (COVID-19) varies significantly among persons similar age and is higher in males. Age-independent, sex-biased differences susceptibility to COVID-19 may be ascribable deficits a sexually dimorphic protective attribute that we termed immunologic resilience (IR).
Non-invasive oxygenation strategies have a prominent role in the treatment of acute hypoxemic respiratory failure during coronavirus disease 2019 (COVID-19). While efficacy these therapies has been studied hospitalized patients with COVID-19, clinical outcomes associated oxygen masks, high-flow therapy by nasal cannula and non-invasive mechanical ventilation critically ill intensive care unit (ICU) remain unclear.
Abstract Hip fractures (HFx) are associated with a higher morbidity and mortality rates, leading to significant reduction in life quality limitation of patient´s mobility. The present study aimed obtain real-world evidence on the clinical characteristics patients an initial second hip fracture develop predictive model for HFx using artificial intelligence. Electronic health records from one hospital centre Spain January 2011 December 2019 were analysed EHRead® technology, based natural...
COVID-19 is primarily a respiratory disease; however, there also evidence that it causes endothelial damage in the microvasculature of several organs. The aim present study to characterize vivo microvascular reactivity peripheral skeletal muscle severe patients.This prospective observational carried out Spain, Mexico and Brazil. Healthy subjects patients admitted intermediate (IRCU) intensive care units (ICU) due hypoxemia were studied. Local tissue/blood oxygen saturation (StO2) local...
Abstract Amyotrophic lateral sclerosis (ALS) is a fatal, neurodegenerative motor neuron disease. Although an early diagnosis crucial to provide adequate care and improve survival, patients with ALS experience significant diagnostic delay. This study aimed use real-world data describe the clinical profile timing between symptom onset, diagnosis, relevant outcomes in ALS. Retrospective multicenter 5 representative hospitals Primary Care services SESCAM Healthcare Network (Castilla-La Mancha,...
The identification of critically ill COVID-19 patients at risk fatal outcomes remains a challenge. Here, we first validated candidate microRNAs (miRNAs) as biomarkers for clinical decision-making in patients. Second, constructed blood miRNA classifier the early prediction adverse ICU.This was multicenter, observational and retrospective/prospective study including 503 admitted to ICU from 19 hospitals. qPCR assays were performed plasma samples collected within 48 h upon admission. A 16-miRNA...
Patients infected with influenza A (H1N1)pdm09 virus requiring admission to the ICU remain an important source of mortality during season. The objective study was assess impact a delay in diagnosis community-acquired infection on clinical outcome critically ill patients admitted ICU.A prospective multicenter observational cohort based data from GETGAG/SEMICYUC registry (2009-2015) collected by 148 Spanish ICUs. All which had been established within first week hospitalization were included....