Jessica González
A5087758612- Long-Term Effects of COVID-19
- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Intensive Care Unit Cognitive Disorders
- Lung Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Sepsis Diagnosis and Treatment
- Thermal Regulation in Medicine
- Lung Cancer Treatments and Mutations
- COVID-19 and Mental Health
- Pulmonary Hypertension Research and Treatments
- Obstructive Sleep Apnea Research
- Nutritional Studies and Diet
- Asthma and respiratory diseases
- Cardiovascular Disease and Adiposity
- Circadian rhythm and melatonin
- Obesity, Physical Activity, Diet
- SARS-CoV-2 and COVID-19 Research
- Cardiovascular Health and Disease Prevention
- Cystic Fibrosis Research Advances
- Respiratory viral infections research
- Bone health and osteoporosis research
- Diabetes, Cardiovascular Risks, and Lipoproteins
Mayo Clinic in Florida
2024-2025
Mayo Clinic
2024-2025
Biomedical Research Institute of Lleida
2019-2025
Instituto de Salud Carlos III
2019-2025
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2019-2025
Hospital Universitari Arnau de Vilanova
2019-2025
Centro de Investigación Biomédica en Red
2022-2024
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2023-2024
The University of Texas Health Science Center at Houston
2024
Mayo Clinic in Arizona
2024
We evaluated whether the time between first respiratory support and intubation of patients receiving invasive mechanical ventilation (IMV) due to COVID-19 was associated with mortality or pulmonary sequelae.
To evaluate the sleep and circadian rest-activity pattern of critical COVID-19 survivors 3 months after hospital discharge.Observational, prospective study.Single-center study.One hundred seventy-two consecutive admitted to ICU with acute respiratory distress syndrome.Seven days actigraphy for assessment; validated questionnaires; tests at 3-month follow-up.The cohort included 172 patients, mostly males (67.4%) a median (25th-75th percentile) age 61.0 years (52.8-67.0 yr). The number was...
OBJECTIVES: To investigate the sleep and circadian health of critical survivors 12 months after hospital discharge to evaluate a possible effect severity disease within this context. DESIGN: Observational, prospective study. SETTING: Single-center PATIENTS: Two hundred sixty patients admitted ICU due severe acute respiratory syndrome coronavirus 2 infection. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The cohort was composed 260 (69.2% males), with median (quartile 1–quartile 3) age...
The primary aim of our study was to investigate the association between intubation timing and hospital mortality in critically ill patients with coronavirus disease 2019 (COVID-19)-associated respiratory failure. We also analysed both impact such throughout first four pandemic waves influence prior noninvasive support on outcomes.This is a secondary analysis multicentre, observational prospective cohort that included all consecutive undergoing invasive mechanical ventilation due COVID-19...
The long-term clinical management and evolution of a cohort critical COVID-19 survivors have not been described in detail. We report prospective observational study patients admitted to the ICU between March August 2020. follow-up post-COVID consultation comprised symptoms, pulmonary function tests, 6-minute walking test (6MWT), chest computed tomography (CT). Additionally, questionnaires evaluate prevalence post-COVID-19 syndrome were administered at 1 year. A total 181 during period. They...
Although the prevalence of community-acquired respiratory bacterial coinfection upon hospital admission in patients with coronavirus disease 2019 (COVID-19) has been reported to be < 5%, almost three-quarters received antibiotics. We aim investigate whether procalcitonin (PCT) or C-reactive protein (CRP) could helpful biomarkers identify among COVID-19 pneumonia. carried out a multicentre, observational cohort study including consecutive admitted 55 Spanish intensive care units (ICUs). The...
Elucidating the pathobiological mechanisms underlying post-acute pulmonary sequelae following SARS-CoV-2 infection is essential for early interventions and patient stratification. Here, we investigated potential of microRNAs (miRNAs) as theranostic agents pulmoprotection in critical illness survivors. Multicenter study including 172 ICU Diffusion impairment was defined a lung-diffusing capacity carbon monoxide (D
Circulating cell-free microRNAs (miRNAs) are promising biomarkers for medical decision-making. Suitable endogenous controls essential to ensure reproducibility. We aimed identify and validate reference miRNAs qPCR data normalization in samples from SARS-CoV-2-infected hospitalized patients. used plasma (n = 170) COVID-19 patients collected at hospital admission (COVID-Ponent project, www.clinicaltrials.gov/NCT04824677). First, 179 were profiled using RT–qPCR. After stability assessment,...
The pathophysiology of COVID-19-related critical illness is not completely understood. Here, we analyzed the microRNA (miRNA) profile bronchial aspirate (BAS) samples from COVID-19 and non-COVID-19 patients admitted to ICU identify prognostic biomarkers fatal outcomes define molecular pathways involved in disease adverse events.Two patient populations were included (n = 89): (i) a study population composed critically ill patients; (ii) prospective cohort survivors non-survivors among...
There is a limited understanding of the pathophysiology postacute pulmonary sequelae in severe COVID-19. The aim current study was to define circulating microRNA (miRNA) profiles associated with function and radiologic features survivors SARS-CoV-2-induced ARDS. included patients who developed ARDS secondary SARS-CoV-2 infection (n = 167) group infected did not develop 33). Patients were evaluated 3 months after hospital discharge. follow-up complete evaluation chest computed tomography....
Abstract Background and Purpose The post‐acute sequelae of SARS‐CoV‐2 infection pose a significant global challenge, with nearly 50% critical COVID‐19 survivors manifesting persistent lung abnormalities. lack understanding about the molecular mechanisms effective treatments hampers their management. Here, we employed microRNA (miRNA) profiling to decipher systemic underpinnings pulmonary complications. Experimental Approach We conducted longitudinal investigation including 119 survivors. A...
To determine the association between Obstructive Sleep Apnea (OSA) with long-term symptoms and inflammatory cytokines, exploring changes 4-months 1-year after COVID-19 infection. We conducted an observational, prospective cohort study, including patients ≥18 years old confirmed diagnosis of April to July 2020. All participants underwent two clinical follow-up visits, first at (Visit 1) second 1 year, SARS-CoV-2 infection 2). Plasma glucose, total cholesterol, HDL, triglycerides. Regarding...
The identification of critically ill COVID-19 patients at risk fatal outcomes remains a challenge. Here, we first validated candidate microRNAs (miRNAs) as biomarkers for clinical decision-making in patients. Second, constructed blood miRNA classifier the early prediction adverse ICU.This was multicenter, observational and retrospective/prospective study including 503 admitted to ICU from 19 hospitals. qPCR assays were performed plasma samples collected within 48 h upon admission. A 16-miRNA...
Sirtuin 1 (Sirt1) is a NAD+ dependent lysine deacetylase associated with the pathogenesis of various diseases including cancer. In many cancer types Sirt1 expression increased. Higher levels have been metastasis and poor prognosis. However, tumor suppressing properties also observed in some instances even dual role for same type has reported. Increased activity linked to life span extension cells respectively organisms by promoting DNA repair processes downregulation suppressor proteins....