A5008292929- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory Support and Mechanisms
- Pleural and Pulmonary Diseases
- Tracheal and airway disorders
- Lung Cancer Treatments and Mutations
- Pulmonary Hypertension Research and Treatments
- Cystic Fibrosis Research Advances
- Bone health and osteoporosis research
- COVID-19 Clinical Research Studies
- Cardiovascular Disease and Adiposity
- Inhalation and Respiratory Drug Delivery
- Respiratory viral infections research
- Esophageal Cancer Research and Treatment
- Long-Term Effects of COVID-19
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging and Pathology Studies
- Asthma and respiratory diseases
- Inflammatory Biomarkers in Disease Prognosis
- SARS-CoV-2 and COVID-19 Research
- Neonatal Respiratory Health Research
- Trauma Management and Diagnosis
- Vascular Anomalies and Treatments
Clinica Universidad de Navarra
2016-2025
Pulmonary Associates
2007-2015
British Association for Immediate Care Scotland
2015
BASilar artery International Cooperation Study
2015
Universidad de Navarra
2005-2014
Hospital Municipal de Badalona
2004
Abstract Importance COVID‐19 is caused by SARS‐CoV‐2, a betacoronavirus that uses the angiotensin‐converting enzyme‐related carboxypeptidase (ACE2) receptor to gain entry into cells. ACE2 widely expressed in multiple organs, including retina, an extension of central nervous system. The involved diabetic and hypertensive retinopathy. Additionally, coronaviruses cause ocular infections animals, retinitis, optic neuritis. Objective To assess whether there any retinal disease associated with...
Multimorbidity frequently affects the ageing population and their co-existence may not occur at random. Understanding interactions that with clinical variables could be important for disease screening management. In a cohort of 1969 chronic obstructive pulmonary (COPD) patients 316 non-COPD controls, we applied network-based analysis to explore associations between multiple comorbidities. Clinical characteristics (age, degree obstruction, walking, dyspnoea, body mass index) 79 comorbidities...
Rationale: Lung cancer screening using computed tomography (CT) is effective in detecting lung early stages. Concerns regarding false-positive rates and unnecessary invasive procedures have been raised. Objective: To study the efficiency of a protocol spiral CT F-18-fluorodeoxyglucose positron emission (FDG-PET). Methods: High-risk individuals underwent with annual CTs. Follow-up CTs were done for noncalcified nodules 5 mm or greater, FDG-PET was 10 larger smaller (> 7 mm), growing nodules....
Patients with chronic obstructive pulmonary disease (COPD) are at high risk for lung cancer (LC) and represent a potential target to improve the diagnostic yield of screening programs.To develop predictive score LC patients COPD.The Pamplona International Early Lung Cancer Detection Program (P-IELCAP) Pittsburgh Screening Study (PLuSS) databases were analyzed. Only COPD on spirometry included. By logistic regression we determined which factors independently associated in PLuSS developed...
Rationale: Lung cancer (LC) screening using low-dose chest computed tomography is now recommended in several guidelines the National Screening Trial (NLST) entry criteria (age, 55–74; ≥30 pack-years; tobacco cessation within previous 15 yr for former smokers). Concerns exist about their lack of sensitivity.Objectives: To evaluate performance NLST two different LC studies from Europe and United States, to explore effect emphysema as a complementary criterion.Methods: Participants Pamplona...
Leptin is a powerful stimulant of ventilation in rodents. In humans, resistance to leptin has been consistently associated with obesity. Raised levels have reported subjects sleep apnoea or obesity-hypoventilation syndrome. The aim the present study was assess, by multivariate analysis, possible association between respiratory centre impairment and serum leptin. total, 364 obese (body mass index >or=30 kg.m(-2)) underwent following tests: studies, function tests, baseline hypercapnic...
Lung cancer screening using computed tomography (CT) is effective in detecting early stage disease. However, concerns regarding adherence have been raised. The current authors conducted a retrospective observational study of 641 asymptomatic smokers enrolled lung programme between 2000 and 2003. Adherent subjects were compared with nonadherent regard to function, sex, age, motivation for enrollment, smoking status, distance the referral centre, family history cancer, asbestos exposure,...
To assess the relationship between lung cancer and emphysema subtypes.
Introduction Little information is available on the surgical treatment options for patients with Airway Obstruction (AO) and early-stage non-small cell lung cancer (NSCLC) followed in screening programs (LCS). This study aims to compare potential impact of anatomical sub lobar resections vs. lobectomies these patients. Methods a retrospective analysis participants who underwent within Lung Cancer Screening Program, including those AO (post bronchodilator FEV 1 /FVC < 0.70). The short-term...
Epicardial Adipose Tissue (EAT) volume as determined by chest computed tomography (CT) is an independent marker of cardiovascular events in the general population. COPD patients have increased risk disease, however nothing known about EAT this population.To assess and explore its association with clinical physiological variables disease severity.We measured using low-dose CT 171 stable 70 controls matched age, smoking history BMI. We blood pressure, cholesterol, glucose HbA1c levels,...
Information on the immunopathobiology of coronavirus disease 2019 (COVID-19) is rapidly increasing; however, there remains a need to identify immune features predictive fatal outcome. This large-scale study characterized responses severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection using multidimensional flow cytometry, with aim identifying high-risk biomarkers. Holistic and unbiased analyses 17 cell-types were conducted 1,075 peripheral blood samples obtained from 868...
Idiopathic pulmonary fibrosis (IPF) has a dismal prognosis. Mesenchymal stromal cells (MSCs) have shown benefit in other inflammatory diseases.To evaluate the safety and feasibility of endobronchial administration bone marrow autologous MSCs (BM-MSC) patients with mild-to-moderate IPF.A phase I multicentre clinical trial (ClinicalTrials.gov NCT01919827) single adult BM-MSCs diagnosed IPF. In first escalating-dose phase, three were included sequentially dose cohorts (10×106, 50×106 100×106...