Juan‐José Garcés
A5032982185- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Chemokine receptors and signaling
- vaccines and immunoinformatics approaches
- Cancer Genomics and Diagnostics
- Chronic Lymphocytic Leukemia Research
- COVID-19 Clinical Research Studies
- Hematopoietic Stem Cell Transplantation
- Cardiac Imaging and Diagnostics
- PI3K/AKT/mTOR signaling in cancer
- Single-cell and spatial transcriptomics
- COVID-19 and healthcare impacts
- Acute Myeloid Leukemia Research
- Coronary Interventions and Diagnostics
- Immunotherapy and Immune Responses
- Acute Myocardial Infarction Research
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Signaling Pathways in Disease
- T-cell and B-cell Immunology
- Immune cells in cancer
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Immunodeficiency and Autoimmune Disorders
- Peptidase Inhibition and Analysis
Clinica Universidad de Navarra
2018-2024
Centro de Investigación Biomédica en Red de Cáncer
2018-2024
Kettering University
2024
Memorial Sloan Kettering Cancer Center
2023-2024
Navarre Institute of Health Research
2019-2023
Staten Island University Hospital
2022
Centro de Investigación Biomédica en Red
2021-2022
Universidad de Navarra
2019
PURPOSE Patients with multiple myeloma (MM) may show patchy bone marrow (BM) infiltration and extramedullary disease. Notwithstanding, quantification of plasma cells (PCs) continues to be performed in BM since the clinical translation circulating tumor (CTCs) remains undefined. PATIENTS AND METHODS CTCs were measured peripheral blood (PB) 374 patients newly diagnosed MM enrolled GEM2012MENOS65 GEM2014MAIN trials. Treatment included bortezomib, lenalidomide, dexamethasone induction followed...
Here, we investigated for the first time frequency and number of circulating tumor plasma cells (CTPC) in peripheral blood (PB) newly diagnosed patients with localized systemic cell neoplasms (PCN) using next-generation flow cytometry (NGF) correlated our findings distinct diagnostic prognostic categories disease. Overall, 508 samples from 264 PCN patients, were studied. CTPC detected PB all active multiple myeloma (MM; 100%), smoldering MM (SMM) (100%), more than half (59%) monoclonal...
Primary plasma cell leukemia (PCL) is the most aggressive monoclonal gammopathy. It was formerly characterized by ≥ 20% circulating cells (CTCs) until 2021, when this threshold decreased to 5%. We hypothesized that primary PCL not a separate clinical entity, but rather it represents ultra-high-risk multiple myeloma (MM) elevated CTC levels.We assessed levels of CTCs multiparameter flow cytometry in 395 patients with newly diagnosed transplant-ineligible MM establish cutoff for identifies...
Large-scale immune monitoring is becoming routinely used in clinical trials to identify determinants of treatment responsiveness, particularly immunotherapies. Flow cytometry remains one the most versatile and high throughput approaches for single-cell analysis; however, manual interpretation multidimensional data poses a challenge when attempting capture full cellular diversity provide reproducible results. We present FlowCT, semi-automated workspace empowered analyze large sets. It...
Abstract Purpose: Early intervention in smoldering multiple myeloma (SMM) requires optimal risk stratification to avoid under- and overtreatment. We hypothesized that replacing bone marrow (BM) plasma cells (PC) for circulating tumor (CTC), adding immune biomarkers peripheral blood (PB) the identification of patients at progression due lost surveillance, could improve International Myeloma Working Group 20/2/20 model. Experimental Design: report outcomes 150 with SMM enrolled iMMunocell...
Normal cell counterparts of solid and myeloid tumors accumulate mutations years before disease onset; whether this occurs in B lymphocytes lymphoma remains uncertain. We sequenced multiple stages the lineage elderly individuals patients with lymphoplasmacytic lymphoma, a singular for studying lymphomagenesis because high prevalence mutated MYD88 . observed similar accumulation random lineages from both cohorts unexpectedly found L265P normal precursor mature lymphoma. uncovered genetic...
Abstract Purpose: Undetectable measurable residual disease (MRD) is a surrogate of prolonged survival in multiple myeloma. Thus, treatment individualization based on the probability patient achieving undetectable MRD with singular regimen could represent new concept toward personalized treatment, fast assessment its success. This has never been investigated; therefore, we sought to define machine learning model predict at onset Experimental Design: study included 487 newly diagnosed patients...
The psychometric hepatic encephalopathy score (PHES) is the "gold standard" for minimal (MHE) diagnosis. Some reports suggest that some cirrhotic patients "without" MHE according to PHES show neurological deficits and other alterations are not homogeneous in all patients. This work aimed assess whether: 1) a relevant proportion of detected by PHES; 2) with mild population or may be classified sub-groups specific deficits.Cirrhotic (n = 56) "with" 41) controls 52) performed tests assessing...
Bone marrow (BM) aspirates are the gold standard for patient prognostication and genetic characterization in multiple myeloma (MM). However, they represent an important limitation periodic disease monitoring because entail aggressive procedure. Moreover, recent findings show that a single BM aspirate is unable to reflect complex MM heterogeneity. Recent advances flow cytometry, microfluidics, "omics" technologies have opened Pandora's box of MM: The detection isolation circulating tumor...
Information on the immunopathobiology of coronavirus disease 2019 (COVID-19) is rapidly increasing; however, there remains a need to identify immune features predictive fatal outcome. This large-scale study characterized responses severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection using multidimensional flow cytometry, with aim identifying high-risk biomarkers. Holistic and unbiased analyses 17 cell-types were conducted 1,075 peripheral blood samples obtained from 868...
INTRODUÇÃO: Refinamentos da intervenção coronária percutânea (ICP), entre eles a utilização do ultrassom intravascular (IVUS) e reserva de fluxo fraccionada (FFR), têm permitido o tratamento lesões complexas com bons resultados. Como consequência, abordagem das TCE se difundiu, incluindo hospitais menor volume procedimentos. Nosso objetivo foi apresentar os resultados iniciais tardios ICP não protegido. MÉTODOS: Foram incluídos pacientes consecutivos tratados em dois centros hospitalares,...