A5081153667- Multiple Myeloma Research and Treatments
- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Chronic Myeloid Leukemia Treatments
- Lymphoma Diagnosis and Treatment
- Genetic Associations and Epidemiology
- Chronic Lymphocytic Leukemia Research
- Protein Degradation and Inhibitors
- Nutrition, Genetics, and Disease
- Genetic factors in colorectal cancer
- BRCA gene mutations in cancer
- Metabolomics and Mass Spectrometry Studies
- Cancer Treatment and Pharmacology
- Gene expression and cancer classification
- Histone Deacetylase Inhibitors Research
- Acute Lymphoblastic Leukemia research
- Cancer Mechanisms and Therapy
- Nutritional Studies and Diet
- CAR-T cell therapy research
- Cancer, Lipids, and Metabolism
- Diet and metabolism studies
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Garlic and Onion Studies
Memorial Sloan Kettering Cancer Center
2020-2025
Kettering University
2023-2025
Ternopil Ivan Pului National Technical University
2023-2024
State University of Trade and Economics
2023-2024
Zhytomyr Polytechnic State University
2024
Division of Cancer Epidemiology and Genetics
2015-2023
Sylvester Comprehensive Cancer Center
2023
Weatherford College
2020-2023
National Cancer Institute
2015-2023
Guy's and St Thomas' NHS Foundation Trust
2023
Coronavirus-2019 (COVID-19) mortality is higher in patients with cancer than the general population, yet cancer-associated risk factors for COVID-19 adverse outcomes are not fully characterized.
Abstract Azacitidine + venetoclax, decitabine and low-dose cytarabine venetoclax are now standard treatments for newly diagnosed older or unfit patients with acute myeloid leukemia (AML). Although these combinations also commonly used in relapsed refractory AML (RR-AML), clinical molecular predictors of response survival RR-AML incompletely understood. We retrospectively analyzed characteristics outcomes 86 who were treated combinations. The complete remission (CR) CR incomplete hematologic...
Acquired somatic mutations in hematopoietic stem and progenitor cells (clonal hematopoiesis or CH) are associated with advanced age, increased risk of cardiovascular malignant diseases, decreased overall survival. These adverse sequelae may be mediated by altered inflammatory profiles observed patients CH. A pro-inflammatory immunologic profile is also worse outcomes certain infections, including SARS-CoV-2 its disease Covid-19. Whether CH predisposes to severe Covid-19 other infections...
PURPOSE Outcomes for patients with newly diagnosed multiple myeloma (NDMM) are heterogenous, overall survival (OS) ranging from months to over 10 years. METHODS To decipher and predict the molecular clinical heterogeneity of NDMM, we assembled a series 1,933 available clinical, genomic, therapeutic data. RESULTS Leveraging comprehensive catalog genomic drivers, identified 12 groups, expanding on previous gene expression–based classifications. build model predicting individualized risk in...
Key Points Treatment-naive and relapsed/refractory MDS patients receiving venetoclax HMAs have an ORR of 59% with 63% responders proceeding to transplant. Allogeneic stem cell transplantation after treatment in combination HMA is associated prolonged survival.
The Consortium of Metabolomics Studies (COMETS) was established in 2014 to facilitate large-scale collaborative research on the human metabolome and its relationship with disease etiology, diagnosis, prognosis. COMETS comprises 47 cohorts from Asia, Europe, North America, South America that together include more than 136,000 participants blood metabolomics data samples collected 1985 2017. were provided by 17 different platforms, most frequently used labs being Metabolon, Inc. (14 cohorts),...
Abstract Multiple myeloma (MM) is consistently preceded by precursor conditions recognized clinically as monoclonal gammopathy of undetermined significance (MGUS) or smoldering (SMM). We interrogate the whole genome sequence (WGS) profile 18 MGUS and compare them with those from 14 SMMs 80 MMs. show that cases a non-progressing, stable condition ( n = 15) are characterized later initiation in patient’s life absence defining genomic events including: chromothripsis, templated insertions,...
Recently, the benefit of adding daratumumab to proteasome inhibitor-based, 3-drug combination bortezomib, lenalidomide, and dexamethasone for patients with newly diagnosed multiple myeloma who underwent high-dose melphalan chemotherapy autologous hemopoietic cell transplant was assessed. Here, we examine addition second-generation carfilzomib, dexamethasone.To assess safety effectiveness carfilzomib-lenalidomide-dexamethasone-daratumumab therapy myeloma, in absence transplant.Clinical...
The rarity of malignant Hodgkin and Reed Sternberg (HRS) cells in classic lymphoma (cHL) limits the ability to study genomics cHL. To circumvent this, our group has previously optimized fluorescence-activated cell sorting purify HRS cells. Using this approach, we now report whole-genome sequencing landscape reconstruct chronology likely etiology pathogenic events leading We identified alterations driver genes not described cHL, APOBEC mutational activity, presence complex structural variants...
Many association tests have been proposed for rare variants, but the choice of a powerful test is uncertain when there limited information on underlying genetic model. Proposed methods use either linear statistics, which are most variants causal and same direction effect, or quadratic more in other scenarios. To achieve robustness, it natural to combine evidence from two complementary tests. this end, we consider minimum‐p Fisher's combining P ‐values statistics. Extensive simulation studies...
Background: Identifying circulating metabolites related to cigarette smoking may provide insight into the biological mechanisms of smoking-related diseases and nature addiction. However, previous studies are limited, generally small, have largely targeted a priori metabolites. Methods: We examined associations between using an untargeted metabolomics approach in 892 men women from four including participants Italy, USA, China Finland. individual log-transformed two key phenotypes (current...
Two recent metabolomic analyses found serum lipid, energy, and other metabolites related to aggressive prostate cancer risk up 20 years prior diagnosis. We conducted a investigation of in the Prostate, Lung, Colorectal, Ovarian Cancer Screening Trial that included annual total prostate-specific antigen measurement digital rectal examination. This nested study 380 cases diagnosed post-screening controls individually matched on age, race, centre, blood-collection date (median time diagnosis,...
Impaired metabolism may play an important role in the pathogenesis of lethal prostate cancer, yet there is a paucity evidence regarding association. We conducted large prospective serum metabolomic analysis cancer 523 cases and matched controls nested within Alpha‐Tocopherol, Beta‐Carotene Cancer Prevention (ATBC) Study. Median time from baseline fasting collection to death was 18 years (maximum 30 years). identified 860 known biochemicals through ultrahigh‐performance LC–MS/MS platform....
Abstract Background Coffee has been consistently associated with lower risk of liver cancer and chronic disease, suggesting that coffee affects mechanisms underlying disease development. Methods We measured serum metabolites using untargeted metabolomics in 1:1 matched nested case-control studies (n = 221 cases) fatal 242 the Alpha-Tocopherol, Beta-Carotene Cancer Prevention cohort 29 133). Associations between baseline drinking were identified linear regression; conditional logistic...
Patients with multiple myeloma have a compromised immune system, due to both the disease and antimyeloma therapies, may therefore be particularly susceptible COVID-19. Here, we report outcomes risk factors for serious in patients treated at five large academic centers New York City spring of 2020, during which it was global epicenter SARS-CoV-2 pandemic. Of 100 (male 58%; median age 68) diagnosed COVID-19, 75 were admitted; these, 13 (17%) placed on invasive mechanical ventilation, 22 (29%)...
Abstract Purpose: Sustained minimal residual disease (MRD) negativity is associated with long-term survival in multiple myeloma. The gut microbiome affected by diet, and turn can modulate host immunity, for example through production of short-chain fatty acids including butyrate. We hypothesized that dietary factors affect the (abundance butyrate-producing bacteria or stool butyrate concentration) may be myeloma outcomes. Experimental Design: examined relationship (via a food frequency...
Abstract B-cell-maturation-antigen (BCMA)-directed therapies are highly active for multiple myeloma, but infections emerging as a major challenge. In this retrospective, single-center analysis we evaluated infectious complications after BCMA-targeted chimeric-antigen-receptor T-cell therapy (CAR-T), bispecific-antibodies (BsAb) and antibody-drug-conjugates (ADC). The primary endpoint was severe (grade ≥3) infection incidence. Amongst 256 patients, 92 received CAR-T, 55 BsAb 109 ADC....
7536 Background: Teclistamab (Tec) is the first BCMAxCD3 bispecific antibody approved for triple-class-exposed relapsed/refractory multiple myeloma (RRMM). The MajesTEC-1 study demonstrated an overall response rate (ORR) of 63% and a median progression-free survival (mPFS) 11.3 months (mos). Herein, we examined real-world pt characteristics outcomes associated with Tec in (1) pts treated within 4 mos approval (early initiators who were expected to have high disease burden) as compared recent...