A5072027170- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- CAR-T cell therapy research
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Mycobacterium research and diagnosis
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Eosinophilic Disorders and Syndromes
- CNS Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Xenotransplantation and immune response
- Multiple Myeloma Research and Treatments
- Neutropenia and Cancer Infections
- Virus-based gene therapy research
- Head and Neck Surgical Oncology
- Lung Cancer Treatments and Mutations
- Salivary Gland Tumors Diagnosis and Treatment
- Retinoids in leukemia and cellular processes
Memorial Sloan Kettering Cancer Center
2020-2025
Cornell University
2024
Government of the United States of America
2022
Center for Cancer Research
2020
National Cancer Institute
2019-2020
National Institutes of Health
2018-2019
Stanford University
2019
University Hospitals of Cleveland
2019
University of Massachusetts Chan Medical School
2015-2019
National Institutes of Health Clinical Center
2018-2019
Phenotypic characterization of immune cells in the bone marrow (BM) patients with acute myeloid leukemia (AML) is lacking.T-cell infiltration was quantified on BM biopsies from 13 AML, and flow cytometry performed aspirates (BMAs) 107 AML who received treatment at The University Texas MD Anderson Cancer Center. authors evaluated expression inhibitory receptors (programmed cell death protein 1 [PD1], cytotoxic T-lymphocyte antigen 4 [CTLA4], lymphocyte-activation gene 3 [LAG3], T-cell...
// Benjamin J. Chen 1 , Ravi Dashnamoorthy 2 Pallavi Galera Vladislav Makarenko Hong Chang 3 Srimoyee Ghosh 4 and Andrew M. Evens Department of Pathology, University Massachusetts Medical School, Worcester, MA, USA Division Blood Disorders, Rutgers Cancer Institute New Jersey, Brunswick, NJ, for Clinical Research Health Policy Studies the Biostatistics, Epidemiology, Design (BERD) Center, Tufts Boston, Tesaro, Waltham, Correspondence to: Chen, email: Benjamin.chen@umassmemorial.org Keywords:...
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Follicular lymphoma (FL) is an indolent B cell with a heterogenous disease course, and patients may not require immediate treatment upon diagnosis. Scrutiny of its microenvironment provide key insights into lymphomagenesis enhancement therapeutic options. We analyzed the T-cell composition large, well-annotated follicular hyperplasia (FH; n=43) cohort utilizing standardized high dimensionality flow cytometry (>150,000 cells analyzed/sample) novel reproducible analytical pipeline leading...
Monomorphic posttransplant lymphoproliferative disorders have been defined as lymphoid or plasmacytic proliferations that fulfill criteria for one of the B-cell T/NK-cell neoplasms recognized in immunocompetent hosts current WHO Classification. Low-grade historically excluded from this category, although rare reports marginal zone lymphoma (MZL) described. We report 9 cases Epstein-Barr virus-negative MZL, all arising solid organ transplant recipients (4 renal, 3 liver, 1 cardiac, and...
Sirolimus is an immunosuppressant used to prevent graft versus host disease in allogeneic hematopoietic stem cell transplant recipients. It has a large volume of distribution (12 ± 7.5 l/kg) and within the intravascular space ∼95% it bound red blood cells. Because potential toxic effects at high trough levels, therapeutic drug monitoring recommended for sirolimus. We present case severe hepatic dysfunction due Hepatitis B sirolimus toxicity, 51‐year‐old male recipient. An automated exchange...
Therapeutic leukapheresis can control the white blood cell count (WBC) of pregnant women with chronic myelogenous leukemia (CML) who have hyperleukocytosis without leukostasis. The medical justification for this treatment has not been objectively documented. We report a 27-year-old woman, diagnosed CML at 10-week gestation, developed severe dyspnea on exertion. A workup that included chest CT and echocardiography bubble study detected no cardiopulmonary pathology to explain her symptoms,...
Background . While 2% of all extranodal Non-Hodgkin Lymphomas present in the thyroid, there exists insufficient data to describe incidence mantle cell lymphoma thyroid. A case series 1400 patients revealed that <1% thyroid lymphomas may be MCL; hence better understanding disease course is essential. Patient Findings 65-year-old female was referred for a multinodular goiter. Multiple fine needle aspirations from dominant right nodule were consistent with Hashimoto’s thyroiditis and flow...
ABSTRACT Mixed phenotype (MP) in acute leukemias poses unique classification and management dilemmas can be seen entities other than de novo mixed leukemia (MPAL). Although WHO empirically recommends excluding AML with myelodysplasia related changes (AML-MRC) therapy (t-AML) (AML-MP) from MPAL, there is lack of studies investigating the clinical, genetic, biologic features AML-MP. We report first cohort AML-MRC t-AML MP integrating their immunophenotypic, genomic transcriptomic comparison to...
Metaplastic breast carcinoma (MBC) is a heterogenous group of tumors that diverge from conventional glandular differentiation. The metaplastic component can be focal or may present purely posing diagnostic challenges. Since MBC show immunostaining even negative for some cytokeratins (CK), different CKs are often needed to prove their epithelial origin. OSCAR relatively new broad-spectrum anti-CK antibody. Thirty cases diagnosed at our institution were retrieved, including 7 spindle cell...