A5002129353- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Viral-associated cancers and disorders
- Chronic Lymphocytic Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hematological disorders and diagnostics
- Immunodeficiency and Autoimmune Disorders
- Congenital Diaphragmatic Hernia Studies
- Histiocytic Disorders and Treatments
- Pleural and Pulmonary Diseases
- Microbial infections and disease research
- Long-Term Effects of COVID-19
- Viral Infections and Vectors
- Animal health and immunology
- Antifungal resistance and susceptibility
- Mosquito-borne diseases and control
- Bone and Joint Diseases
- Intestinal and Peritoneal Adhesions
- Eosinophilic Disorders and Syndromes
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Head and Neck Anomalies
- Urological Disorders and Treatments
- Ethnobotanical and Medicinal Plants Studies
Memorial Sloan Kettering Cancer Center
2023-2025
Stanford University
2019-2023
Maulana Azad Medical College
2008-2023
Indian Institute of Technology Delhi
2022-2023
Stanford Medicine
2022
Ranchi University
2020-2021
Banaras Hindu University
2020
Indian Institute of Technology BHU
2020
Palo Alto University
2019
Maulana Azad Institute of Dental Sciences
2019
Purpose: To list the clinico-epidemiological profile and possible risk factors of COVID-19 associated rhino-orbital-cerebral mucormycosis (CA-ROCM) patients presenting to a COVID dedicated hospital during second wave in India. Patients Methods: A cross-sectional, single-center study was done on 60 cases probable CA-ROCM based clinical features supportive diagnostic nasal endoscopic findings and/or radiologic findings. with recent or active were included. The demographic profile, features,...
Comprehensive genomic sequencing is becoming a critical component in the assessment of hematologic malignancies, with broad implications for patients’ management. In this context, unequivocally discriminating somatic from germline events challenging but greatly facilitated by matched analysis tumor:normal pairs samples. contrast to solid tumors, malignancies conventional sources normal control material (peripheral blood, buccal swabs, saliva) could be highly involved neoplastic process,...
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Mass lesions in the retroperitoneal space may be primary or secondary. Primary mass are relatively uncommon as compared to pathology that arises secondarily from organs. These solid cystic lesions. The overlapping imaging features of various tumors make diagnosis difficult, and hence, histopathology remains mainstay diagnosis. This paper provides a brief review anatomy an algorithmic approach based on cross-sectional techniques narrow down differential masses encountered adult population.
Post-transplant lymphoproliferative disorders (PTLD) are diseases occurring in immunocompromised patients after hematopoietic stem cell transplantation (HCT) or solid organ (SOT). Although PTLD occurs rarely, it may be associated with poor outcomes. In most cases, is driven by Epstein-Barr virus (EBV) infection. Few studies have investigated the mutational landscape and gene expression profile of PTLD. our study, we performed targeted deep sequencing RNA-sequencing (RNA-Seq) on 16 cases...
Kikuchi-Fujimoto disease (KFD) and systemic lupus erythematosus (SLE) are benign entities with histologic features that raise concern about malignancy infection. We searched for a histology-independent KFD/SLE signature relying on only immunophenotype basic clinical characteristics.A was generated using 975 excised lymph nodes flow immunophenotyping, including 16 cases of KFD/SLE. This then evaluated in 1,198 fine-needle aspiration (FNA) specimens.The top cytometry discriminant uniform CD38+...
Angioimmunoblastic T‑cell lymphoma (AITL) is a uniquely aggressive mature neoplasm. In recent years, recurrent genetic mutations in ras homolog family member A (RHOA), tet methylcytosine dioxygenase 2 (TET2), DNA methyltransferase 3 alpha (DNMT3A) and isocitrate dehydrogenase [NADP(+)] (IDH2) have been identified as associated with AITL. However, deep molecular study assessing both RNA expression profile combined digital image analysis lacking. The present aimed to evaluate the significance...
During an outbreak of dengue viral infection in India, a 68-year-old woman presented with fever and myalgia for 4 days altered sensorium 1 day. At presentation, she was comatose Glasgow Coma score 6. Physical examination showed high (39°C), mild conjunctival injection hepatosplenomegaly. The pulse rate blood pressure were within normal limits. tourniquet test positive. Laboratory investigations leucocytosis, thrombocytopenia (65 000 per mm3) increased haematocrit (48.7%). Prothrombin …
During an outbreak of dengue viral infection in India, a 68-year-old woman presented with fever and myalgia for 4 days altered sensorium 1 day. At presentation, she was comatose Glasgow Coma score 6. Physical examination showed high (39°C), mild conjunctival injection hepatosplenomegaly. The pulse rate blood pressure were within normal limits. tourniquet test positive. Laboratory investigations leucocytosis, thrombocytopenia (65 000 per mm3) increased haematocrit …
We describe a 4-year-old boy who presented with progressive right periorbital edema and proptosis, no systemic symptoms, was found to have B-lymphoblastic leukemia (B-ALL). Magnetic resonance imaging (MRI) showed an enhancing mass centered in the superolateral extraconal orbit. Orbital biopsy consistent B-ALL (CD99, TdT, LCA cocktail, CD34, CD79, CD10, PAX5, MIB1 positive; CD3, CD20 negative). A subsequent bone marrow aspirate confirmed diagnosis of 80% blasts by flow cytometry haploid...
Aims An indolent T‐lymphoblastic proliferation (iT‐LBP) is a benign, reactive expansion of immature terminal deoxynucleotidyl transferase (TdT)‐positive T cells found in extrathymic tissues. iT‐LBP can be challenging to distinguish from malignant processes, specifically lymphoma (T‐LBL), given the overlapping clinical and histological features. Recently, it has been shown that LIM domain only 2 (LMO2) overexpressed T‐LBL but not TdT+ thymus. On basis these findings, aim this study was...
Abstract Objectives Histiocytic neoplasms demonstrate shared gene translocations and clonal immunoglobulin rearrangements in cases of associated B-cell lymphomas. However, the evolution these related disease processes remains largely uncertain, especially setting a prior mantle cell lymphoma. Methods We describe unique case histiocytic sarcoma that transdifferentiated from blastoid lymphoma after extensive therapy. Cytogenic molecular studies were performed provided evidence for progression....
Castleman disease (CD) is a rare lymphoproliferative disorder with distinct clinical subtypes. However, our understanding of the underlying pathogenesis particular subtypes CD remains unclear. While characteristic morphologic changes within UCD, including occasional cases overgrowth spindled stromal and follicular dendritic cells have been described, nature origin these spindle remain elusive. Few reports suggested that in UCD are clonally neoplastic may be fibroblastic reticular cell (FRC)...