A5071517114- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- Global Cancer Incidence and Screening
- Global Health Workforce Issues
- CAR-T cell therapy research
- Global Health and Surgery
- Ovarian cancer diagnosis and treatment
- Advances in Oncology and Radiotherapy
- Lung Cancer Research Studies
- Breast Implant and Reconstruction
- Cytomegalovirus and herpesvirus research
- CNS Lymphoma Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Orthopaedic implants and arthroplasty
- Mycobacterium research and diagnosis
- Colorectal and Anal Carcinomas
- Breast Cancer Treatment Studies
- Parvovirus B19 Infection Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Chronic Lymphocytic Leukemia Research
- Cancer Genomics and Diagnostics
- Sarcoma Diagnosis and Treatment
- Total Knee Arthroplasty Outcomes
University of Vermont
2023-2025
Stanford University
2021-2024
University of Virginia Medical Center
2022
Stanford Medicine
2021
University of Virginia
2018-2021
University of Virginia Health System
2020-2021
Epstein-Barr virus (EBV) is responsible for many B cell lymphoproliferative disorders (LPD) spanning subclinical infection to immunodeficiency-related neoplasms. EBV establishes a latent in the host as defined histologically by expression of membrane proteins and nuclear antigens. Herein, we characterize latency patterns neoplasms including post-transplant (PTLD) therapy-related LPD (formerly iatrogenic) with protein-1 (LMP-1) antigen-2 (EBNA-2) immunohistochemistry. The pattern was...
The immune regulatory enzyme indoleamine-2,3-dioxygenase (IDO-1) suppresses T cell responses and may reduce efficacy of therapies targeting checkpoints such as programmed death receptor-1/programmed ligand-1 (PD-1/PD-L1). Early phase clinical trials combining IDO-1 PD-1/PD-L1 inhibitors have shown some promise in non-small lung cancers (NSCLCs). However, the coexpression PD-L1 has not been thoroughly investigated, potential for immunohistochemical expression a therapeutic biomarker is...
Abstract Immune checkpoint (IC) therapy with anti-PD1 agents is typically used in treatment-refractory classic Hodgkin lymphoma (CHL). However, we present a rare case of composite Follicular (cFL) and CHL whereby frontline use (Nivolumab) combination standard AVD (Doxorubicin, Vinblastine, Dacarbazine) was clinically justified. We performed the Visium spatial transcriptomics assay to gain insight into unique tumor cell characteristics immune composition microenvironment both pre- post-IC...
It is becoming increasingly important to obtain detailed diagnostic information on small-volume tissue biopsies, such as core needle biopsies. This particularly crucial in the workup and diagnosis of classic Hodgkin lymphoma (CHL) other morphologically similar lymphomas T-cell/histiocyte-rich large B-cell (THRLBL), where lymph node biopsies often represent frontline source, differential includes a reactive process. Immunohistochemical markers could be helpful differentiate CHL from changes...
Extensor mechanism disruption after total knee arthroplasty is a relatively rare but potentially devastating complication. One technique to address this problem involves reconstruction with synthetic mesh. Although there are reports of successful clinical outcomes using technique, we not aware any histological analyses removed mesh grafts. This case report failed includes retrieval analysis demonstrating robust host soft-tissue incorporation into the graft and supports rationale for...
Small-volume biopsies (SVBs) including fine-needle aspiration (FNA), cell block, and needle core (NCB) are increasingly utilized to diagnose guide the clinical management of lymphoma. We established a multi-institutional interdisciplinary collaboration cytopathologists, hematopathologists, oncologists focused on role SVB in patients with follicular lymphoma (FL). To assess performance characteristics this setting, we evaluated all consecutive SVBs performed for indications initial diagnosis,...
Diagnosis of histologic transformation (HT) follicular lymphoma (FL) requires tissue biopsy. While surgical biopsy represents the gold standard, less invasive procedures such as fine-needle aspiration (FNAB) and core needle (CNB) are frequently performed. In this retrospective multi-institutional study including 269 patients with FL suspected HT, median time from initial clinical suspicion to final diagnostic was similar whether workup began FNAB, CNB, or (4, 9, 6 days, respectively; p=.27),...
Abstract Objectives Pathology and laboratory medicine (PALM) services in low- middle-income countries are essential to combat the increasing prevalence of cancer addition providing documentation types trends for future allocation public health resources. There many ways PALM as a whole can engage on global front. This study summarizes efforts results educational clinical elective pathology residents Quetzaltenango, Guatemala. Methods led implemented project, working alongside an in-country...
Abstract Background Few studies have evaluated diagnostic yield of small volume biopsies (SVB) for the diagnosis and management follicular lymphoma (FL). Methods The authors performed a multi‐institutional retrospective analysis SVBs including fine‐needle aspiration (FNA) needle core biopsy (NCB) initial FL suspected recurrence or transformation FL. A total 676 workups beginning with SVB were assessed mean number per workup, proportion requiring multiple biopsies, complete grade, on biopsy....
Small-volume biopsy-fine-needle aspiration biopsy (FNAB) with or without core biopsy-is in increasing use diagnosis and management of lymphoma patients. Our objective was to survey the current practice small-volume lymphoma, focusing on interaction among hematopathologists cytopathologists integration FNAB, biopsy, flow cytometry studies at sign-out.This study used a cross-sectional design employing RedCap database distributed via nine pathology professional society email listservs. The...
Graduate-level pathology education is under-resourced in low/middle-income countries (LMIC) and provides a unique opportunity for building sustainable collaborations. By focusing on bi-directional educational exchange through graduate medical training Pathology Laboratory Medicine (PALM), global collaborations can extend to research scholarship efforts. There are few PALM-based programs high-income (HIC) that offer this type of exchange, the exist have been mitigated by pandemic-related...