A5091392056- Pancreatic and Hepatic Oncology Research
- Head and Neck Surgical Oncology
- Salivary Gland Tumors Diagnosis and Treatment
- Tracheal and airway disorders
- Neuroendocrine Tumor Research Advances
- Epigenetics and DNA Methylation
- Fibroblast Growth Factor Research
- Ear and Head Tumors
- Pancreatitis Pathology and Treatment
- Head and Neck Cancer Studies
- Tumors and Oncological Cases
- Gastrointestinal disorders and treatments
- Gastrointestinal Tumor Research and Treatment
- Oral and Maxillofacial Pathology
- Thyroid Cancer Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Treatments and Mutations
- Protein Degradation and Inhibitors
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- Cancer Research and Treatments
- Head and Neck Anomalies
- Cancer, Hypoxia, and Metabolism
- Cancer and Skin Lesions
University of Virginia
2016-2025
University of Virginia Medical Center
2011-2025
University of Virginia Hospital
2018-2024
University of Virginia Health System
2012-2023
UPMC Hillman Cancer Center
2022
Cancer Research Institute
2022
University of Pennsylvania
2022
Health Center
2021
Iowa City Public Library
2019
University Medical Center
2003-2018
NUT midline carcinoma (NMC) is a uniformly lethal malignancy that defined by rearrangement of the nuclear protein in testis (NUT) gene on chromosome 15q14. NMCs are morphologically indistinguishable from other poorly differentiated carcinomas, and diagnosis usually made currently fluorescence situ hybridization (FISH). As normal expression confined to ovary, we reasoned an immunohistochemical (IHC) stain for would be useful diagnosing NMC. To this end, raised highly specific rabbit...
Fine-needle aspiration (FNA) is an important test for triaging patients with thyroid nodules. The 2007 National Cancer Institute Thyroid Fine-Needle Aspiration State-of-the-Science Conference helped instigate the recent publication of Bethesda System Reporting Cytopathology. We reviewed 3,080 FNA samples and recorded interpretations according to proposed standardized 6-tier nomenclature, pursued follow-up cytology histology. Of FNAs, 18.6% were nondiagnostic, 59.0% benign, 3.4% atypical...
To more fully characterize the clinical and pathologic spectrum of a recently described tumor entity sinonasal tract characterized by loss nuclear expression SMARCB1 (INI1), we analyzed 39 SMARCB1-deficient carcinomas collected from multiple medical centers. The tumors affected 23 males 16 females with an age range 19 to 89 years (median, 52). All patients presented locally advanced disease (T3, n=5; T4, n=27) involving sinuses (mainly ethmoid) variable involvement nasal cavity. Thirty...
Human papillomavirus (HPV)–related multiphenotypic sinonasal carcinoma (HMSC), originally known as HPV-related with adenoid cystic carcinoma-like features, is a peculiar neoplasm that restricted to the tract, exhibits features of both surface-derived and salivary gland (particularly carcinoma), associated high-risk HPV. Given limited number published cases, full clinicopathologic spectrum this unclear. Here, we present an updated experience 49 cases. All cases HMSC were obtained from...
Background Undifferentiated carcinomas of the upper aerodigestive tract (UCUAT) occur most frequently within nasopharynx and are often associated with infection by Epstein-Barr virus (EBV) (WHO undifferentiated nonkeratinizing squamous cell carcinoma). An unusual group aggressive characterized translocations that involve Nuclear Protein in Testis (NUT), a novel gene on chromosome 15. In about two-thirds cases, NUT is fused to BRD4 19. These tumors, here termed midline (NMCs),...
Current therapies for pancreatic ductal adenocarcinoma (PDA) target individual tumor cells. Focal adhesion kinase (FAK) is activated in PDA, and levels are inversely associated with survival. We investigated the effects of PF-562,271 (a small-molecule inhibitor FAK/PYK2) on (i) vitro migration, invasion, proliferation; (ii) proliferation, metastasis a murine model; (iii) stromal cell composition PDA microenvironment. Migration assays were conducted to assess migration response cellular...
All clinically and ultrasonographically suspected examples of intraductal papillary-mucinous neoplasm (IPMN) aspirated during a 17-month period were reviewed analyzed for follow-up. We identified 18 cases IPMN in patients 52 to 87 years old. had dilated pancreatic ducts, with 3 showing sonographically apparent papillary lesions; 5 adjacent cystic or solid masses. Cytologic preparations showed thick, glistening, viscid, abnormal mucus all cases. Aspirates from 13 lesions (72%) acellular...
Although small cell carcinoma of the gastrointestinal (GI) tract is well-recognized, nonsmall type high-grade neuroendocrine (HGNEC) this site remains undefined. At current time, neither World Health Organization nor American Joint Committee on Cancer includes condition in histologic classifications, and consequently it being diagnosed treated inconsistently. In study, we aimed at delineating immunophenotypical spectrum HGNECs GI with emphasis subtypes. Guided primarily by...
Human papillomavirus (HPV)-related carcinomas of the head and neck are characterized by a predilection for oropharynx, nonkeratinizing squamous morphology, infection with HPV 16 type; but comprehensive testing across all sites has shown that pathologic features HPV-related carcinoma may be more wide ranging than initially anticipated. In particular, subset sinonasal positive, these include variant is histologically similar to adenoid cystic (ACC). Cases were identified retrospective...
Endobronchial ultrasound–guided transbronchial fine-needle aspiration (EBUS-TBNA) is a new technique that facilitates cytologic sampling of mediastinal lymph nodes. We describe our initial experience with this method, including adequacy assessment, impact on cytopathologists' work, and diagnostic pitfalls. There were 229 EBUS-TBNA samples obtained from 100 patients; mean 22 minutes was spent an average 3 passes performed 6 slides prepared per site. Of 193 aspirates, 5 categorized as...
Papillary squamous cell carcinoma (SCC) is an uncommon variant of SCC in the upper aerodigestive tract. It most frequently located larynx, oropharynx, and sinonasal tract, more common older men. Because its complex exophytic papillary architecture, histologic assessment underlying invasion can be challenging. Risk factors pathogenesis are unclear. We reviewed 31 SCCs tract seen at our institution over a 17-year period with respect to p16 immunoreactivity human papillomavirus (HPV) status....
Information on the clinicopathologic characteristics of invasive carcinomas arising from mucinous cystic neoplasms (MCNs) is limited, because in many early studies they were lumped and analyzed together with noninvasive MCNs. Even more importantly, largest prior did not require ovarian-type stroma (OTS) for diagnosis. We 178 MCNs, all strictly defined by presence OTS, 98% which occurred perimenopausal women (mean age, 47 y) arose distal pancreas. Twenty-nine (16%) patients had associated...
Mitochondria undergo fission and fusion to maintain homeostasis, tumors exhibit the dysregulation of mitochondrial dynamics. We recently demonstrated that ectopic HRasG12V promotes fragmentation tumor growth through Erk phosphorylation GTPase Dynamin-related protein 1 (Drp1). However, role Drp1 in setting endogenous oncogenic KRas remains unknown. Here, we show is required for KRas-driven anchorage-independent fibroblasts patient-derived pancreatic cancer cell lines, it glycolytic flux, part...
The Ewing sarcoma breakpoint region 1 (EWSR1) is translocated in many sarcomas. Recently, its rearrangement has been described salivary gland hyalinizing clear cell carcinomas (HCCCs) and a subset of soft tissue myoepitheliomas. This study examines the presence EWSR1 variety lesions including classic myoepitheliomas HCCCs. Using microarray whole-mount sections, fluorescence situ hybridization (FISH) was performed on detected 87% HCCCs (13 15); all other had intact EWSR1. Patients with...
Mammary analogue secretory carcinoma (MASC) of the salivary glands is a newly described tumor entity associated with t(12;15)(p13;q25) ETV6-NTRK3 translocation. Early studies have shown this to be distinct histologic, biologic, and clinical differences from acinic cell adenocarcinoma, not otherwise specified. Because was only recently, it remains relatively unknown outside head neck specialty pathology centers.In current study, 6 cases fine-needle aspiration cytology histologically and/or...
Sinonasal undifferentiated carcinoma (SNUC) is a high-grade malignancy with limited treatment options and poor outcome. A morphological spectrum of 47 sinonasal tumours including 17 (36.2%) SNUCs was analysed at genomic level. Thirty carcinomas (cohort 1) were subjected to hybridization exon-capture next-generation sequencing assay (MSK-IMPACTTM ) interrogate somatic variants in 279 or 410 cancer-related genes. Seventeen 2) examined only for the presence IDH1/2 exon 4 mutations by Sanger...
The tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) plays a key role progression and response to therapy. dense PDAC stroma causes hypovascularity, which leads hypoxia. Here, we showed that hypoxia drives long-lasting epithelial-mesenchymal transition (EMT) primarily through positive-feedback histone methylation-MAPK signaling axis. Transformed cells preferentially underwent EMT hypoxic regions multiple model systems. Hypoxia drove cell autonomous cells, which, unlike...