A5101675972- Inflammatory Bowel Disease
- Microscopic Colitis
- Colorectal Cancer Surgical Treatments
- Cutaneous Melanoma Detection and Management
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Epigenetics and DNA Methylation
- Surgical site infection prevention
- Pancreatic and Hepatic Oncology Research
- Urinary and Genital Oncology Studies
- Genetic and rare skin diseases.
- Genetic factors in colorectal cancer
- Cancer and Skin Lesions
- Autophagy in Disease and Therapy
- Pneumocystis jirovecii pneumonia detection and treatment
- Radiomics and Machine Learning in Medical Imaging
- Dermatologic Treatments and Research
- HIV-related health complications and treatments
- Dermatology and Skin Diseases
- Nonmelanoma Skin Cancer Studies
- Intraperitoneal and Appendiceal Malignancies
- Trauma Management and Diagnosis
- Autoimmune and Inflammatory Disorders
- Microtubule and mitosis dynamics
- MRI in cancer diagnosis
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2025
Peking Union Medical College Hospital
2017-2025
University of Massachusetts Chan Medical School
2021
Qilu Hospital of Shandong University
2021
First Hospital of Jilin University
2018
Jilin University
2018
Kunming University
2018
Yunnan Center for Disease Control And Prevention
2018
National Institute of Allergy and Infectious Diseases
2008
Although small cell carcinoma of the gastrointestinal (GI) tract is well-recognized, nonsmall type high-grade neuroendocrine (HGNEC) this site remains undefined. At current time, neither World Health Organization nor American Joint Committee on Cancer includes condition in histologic classifications, and consequently it being diagnosed treated inconsistently. In study, we aimed at delineating immunophenotypical spectrum HGNECs GI with emphasis subtypes. Guided primarily by...
Background: Gastrointestinal ultrasound (GIUS) is recommended for monitoring Crohn’s disease (CD). GIUS scores are used to quantify CD activity. Among them, IBUS-SAS (International Bowel Ultrasound Segmental Activity Score), BUSS (Bowel Simple-US (Simple and SUS-CD Score Disease) most commonly used. This study aimed compare correlate the performance of such indicators with endoscopic activity calculate interobserver agreement. Methods: Consecutive patients at our hospital between June 2015...
Pruritus is the most common complication of intrathecal morphine; however, its exact molecular mechanism unclear, and treatment challenging. The analgesic effect N-methyl-D-aspartate (NMDA) receptor antagonists morphine-associated increase in NMDA activation suggest potential role spinal itch sensation. Male C57BL/6 mice were given morphine to induce scratching behavior. effects NMDA, ketamine, ifenprodil U0126 on morphine-induced pruritus analgesia evaluated also. number responses was...
Abstract Objective This study aims to investigate the effect of polo‐like kinase 1 ( PLK1 ) inhibition on cisplatin (DDP)‐resistant gastric cancer (GC) cells. Methods: The transcriptional level was measured by quantitative reverse‐transcription polymerase chain reaction. Expressions and its downstream mediators as well autophagy‐related protein LC3 I/LC3 II were detected western blot. An 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay 5‐ethynyl‐2′‐deoxyuridine...
Colorectal cancer patients respond inconsistently to immunotherapies, likely due the immune microenvironments around their tumors. We analyzed relationship between deficient mismatch repair (dMMR) and colorectal microenvironment identify predictors of effective immunotherapy. (n=113) who had undergone surgical resection were divided into dMMR proficient (pMMR) groups. The levels checkpoint proteins, including programmed cell death 1 (PD-1), ligand (PD-L1), indoleamine 2,3 dioxygenase CD8...
Basal cell carcinoma (BCC) is the most common cutaneous malignancy. Occasionally, it may have an appearance similar to that of some benign pigmented skin lesions. Therefore, additional information needed differentiate these lesions.A diagnostic accuracy study was performed from February 2018 April 2019. All lesions underwent ultrasound examination with 50 and 20 MHz probes. The high-frequency (HFUS) images were evaluated independently by 2 experienced doctors for presence predefined...
Stricture is a common complication in Crohn's disease (CD). Accurate identification of strictures that poorly respond to biologic therapy essential for making optimal therapeutic decisions. The aim this study was determine the association between ultrasound characteristics and their outcomes.
To develop a nomogram for predicting axillary lymph node (ALN) metastases using the breast imaging reporting and data system (BI-RADS) ultrasound lexicon.A total of 703 patients from July 2015 to January 2018 were included in this study as primary cohort model construction. Moreover, 109 including 51 pathologically confirmed N1 (TNM staging) 58 non-metastatic recruited an external validation March August 2019. Ultrasound images clinical information these retrospectively reviewed. The...
Melanocytic nevi (MN) can be classified into three subtypes according to the depth of nests nevus cells which is important for management. High-frequency ultrasound (HF-US) clearly reveal lesion size, contour, depth, and internal structures. However, HF-US studies MN are limited. We aimed describe features explore its value in accurate classification.This retrospective study was conducted from January 2018 November 2019. Eighty-five patients with were included examined by 50 20 MHz HF-US....
Abstract The application of chemotherapy in non‐small cell lung cancer (NSCLC) is limited by the toxicity to normal cells and development multi‐drug resistance. Targeted using cytotoxic analogs against specific receptors on could be a less toxic more efficacious approach. We identified that expressions somatostatin receptor (SSTR) 2 5 tumor tissues from NSCLC patients were higher than those adjacent immunohistochemistry, therefore, analogues might applied for SSTRs‐mediated targeted therapy...
Abstract Objectives Creeping fat (CF) is associated with stricture formation in Crohn’s disease (CD). This study evaluated the feasibility of intestinal ultrasound (IUS) for semiquantitative analysis CF and compared agreement between IUS computed tomography enterography (CTE). Methods In this retrospective study, we recruited consecutive CD patients who underwent CTE. wrapping angle was analyzed on most affected bowel segment independently by We cross- vertical sections diseased bowel....