A5086211710- Breast Cancer Treatment Studies
- Ruminant Nutrition and Digestive Physiology
- Radiomics and Machine Learning in Medical Imaging
- AI in cancer detection
- Gut microbiota and health
- Ultrasound and Hyperthermia Applications
- Parathyroid Disorders and Treatments
- MicroRNA in disease regulation
- Breast Lesions and Carcinomas
- Cancer Mechanisms and Therapy
- HER2/EGFR in Cancer Research
- Thyroid and Parathyroid Surgery
- Circular RNAs in diseases
- Synthesis and Characterization of Heterocyclic Compounds
- Melanoma and MAPK Pathways
- Generative Adversarial Networks and Image Synthesis
- MRI in cancer diagnosis
- Toxin Mechanisms and Immunotoxins
- Viral gastroenteritis research and epidemiology
- Glioma Diagnosis and Treatment
- Phenothiazines and Benzothiazines Synthesis and Activities
- Colorectal Cancer Surgical Treatments
- Autophagy in Disease and Therapy
- Inflammatory Bowel Disease
- Thermography and Photoacoustic Techniques
Peking Union Medical College Hospital
2020-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
The Fourth People's Hospital
2024
Wuhan University
2021-2023
Renmin Hospital of Wuhan University
2021-2023
Nanjing Agricultural University
2016-2017
There is limited knowledge about the impact of long-term feeding a high concentrate diet on rumen microbiota, metabolome and host cell functions. In this study, combination mass spectrometry-based metabolomics techniques, 454 pyrosequencing 16S rDNA genes, RT-PCR was applied to evaluate changes ruminal microbiota composition, metabolites, related genes expression in epithelial cells lactating goats received either 35% or 65% for 4 19 wks, respectively. Results show that reduced diversity led...
Abstract Renal ischemia–reperfusion injury (IRI) is mainly responsible for acute kidney which there no effective therapy. Accumulating evidence has indicated the important role of mitophagy in mitochondrial homeostasis under stress. OGG1 (8‐oxoguanine DNA glycosylase) known functions excision repair nuclear and DNA. However, renal IRI remains unclear. Herein, we identified OGG1, induced during IRI, as a key factor mediating hypoxia‐reoxygenation‐induced apoptosis vitro tissue damage model....
Abstract A mucus layer coats the gastrointestinal tract and serves as first line of intestinal defense against infection. N-acyl-homoserine lactone (AHL) quorum-sensing molecules produced by gram-negative bacteria in gut can influence homeostasis epithelium. In this study, we investigated effects two representative long- short-chain AHLs, N-3-(oxododecanoyl)-homoserine (C12-HSL) N-butyryl homoserine (C4-HSL), on cell viability secretion LS174T cells. C12-HSL but not C4-HSL significantly...
Studies on the effect of a high-concentrate (HC) diet hindgut microbiota and metabolome ruminants are rarely reported. We used 454 pyrosequencing 16S rDNA genes gas chromatography–mass spectrometry to evaluate effects long-term feeding (HL) or short-term (HS) an HC changes in bacterial their metabolites hindgut, with Guanzhong goat as ruminant model. Results indicated that decreased diversity induced metabolic disorder hindgut. The levels lactate, endotoxin (lipopolysaccharide [LPS]),...
Renal ischemia-reperfusion injury (IRI) is one of the underlying causes acute kidney and also an unavoidable problem in renal transplantation. Lots miRNAs targets have been found to participate some post-transcriptional processes IRI, however, detailed knowledge miRNA mechanism unknown. In this study, miR-124 was inhibited PARP1 overexpressed IRI cells mouse models. Dual-luciferase reporter assay revealed that post-transcriptionally regulated PAPR1 3'UTR activity. Our results demonstrated...
To develop a deep-learning system for the automatic identification of triple-negative breast cancer (TNBC) solely from ultrasound images. A total 145 patients and 831 images were retrospectively enrolled at Peking Union College Hospital April 2018 to March 2019. Ultrasound clinical information collected accordingly. Molecular subtypes determined immunohistochemical (IHC) results. CNN with VGG-based architecture was then used predict TNBC. The model's performance evaluated using randomized...
It is well known that feeding a high concentrate (HC) diet to lactating ruminants likely induces subacute ruminal acidosis (SARA) and leads decrease in milk fat production. However, the effects of HC for long periods on fatty acids composition mechanism behind decline still remains poorly understood. The aim this study was investigate impact dairy goats yield with an emphasis mechanisms underlying depression. Seventeen mid-lactating were randomly allocated three groups. control treatment fed...
Abstract Background Accurate identification of parathyroid lesions in primary hyperparathyroidism (PHPT) patients is essential for minimally invasive surgery during pregnancy. Materials and methods Patients who were diagnosed with PHPT pregnancy had undergone surgical treatment between January 2005 September 2023 retrospectively included. Demographic clinical characteristics preoperative ultrasound (US) technetium-99m sestamibi ( 99m Tc-MIBI) scintigraphy results collected. Histopathologic...
<title>Abstract</title> Foundational models have emerged as powerful tools for addressing various tasks in clinical settings. However, their potential development to breast ultrasound analysis remains untapped. In this paper, we present BUSGen, the first foundational generative model specifically designed image analysis. Pretrained on over 3.5 million images, BUSGen has acquired extensive knowledge of structures, pathological features, and variations. With few-shot adaptation, can generate...
Owing to the heavy health burdens from rheumatoid arthritis, a sensitive and objective imaging method is needed for early diagnosis accurate evaluation of disease. We aimed fabricate vascular epithelial growth factor (VEGF)–targeted microbubbles (MBs) evaluate expression levels VEGF within inflammatory lesions rats with adjuvant-induced arthritis (AIA) using multimodal photoacoustic (PA)/ultrasound (US) system. Fluorescein isothiocyanate–biotin double-labeled endothelial receptor 2...
To develop a nomogram for predicting axillary lymph node (ALN) metastases using the breast imaging reporting and data system (BI-RADS) ultrasound lexicon.A total of 703 patients from July 2015 to January 2018 were included in this study as primary cohort model construction. Moreover, 109 including 51 pathologically confirmed N1 (TNM staging) 58 non-metastatic recruited an external validation March August 2019. Ultrasound images clinical information these retrospectively reviewed. The...
The 70-gene signature (70-GS, MammaPrint) test has been recommended by the main guidelines to evaluate prognosis and chemotherapy benefit of hormonal receptor positive human epidermal 2 negative (HR + /Her2-) early breast cancer (BC). However, this expensive assay is not always accessible affordable worldwide. Based on our previous study, we established nomogram models predict binary quartile categorized risk 70-GS.We retrospectively analyzed a consecutive cohort 150 female patients with HR...
Data-driven deep learning models have shown great capabilities to assist radiologists in breast ultrasound (US) diagnoses. However, their effectiveness is limited by the long-tail distribution of training data, which leads inaccuracies rare cases. In this study, we address a long-standing challenge improving diagnostic model performance on cases using long-tailed data. Specifically, introduce pipeline, TAILOR, that builds knowledge-driven generative produce tailored synthetic The model,...
Abstract NF‐κB, a critical cytokine of inflammatory bowel diseases (IBD), is viable marker to reflect the activity intestine. We aimed develop NF‐κB‐targeted microbubbles (MBs) and perform molecular contrast‐enhanced ultrasound (CEUS) quantify NF‐κB expressions on intestinal wall in IBD mice vivo. In this study, MBs were fabricated by connecting biotin‐loaded antibodies avidin‐loaded MBs. presented as transparent round bubbles with an average diameter 1.03/μm±0.01. The specific binding...
Abstract Purpose To construct an effective prognostic nomogram for patients with clinically localized Acral lentiginous melanoma (ALM). Methods This retrospective study included ALM from the Surveillance, Epidemiology, and End Results (SEER) database 2004–2015. The 1686 cases were divided into training internal validation cohorts at a ratio of 7:3. Cox regression analyses performed to select risk factors nomogram. performances evaluated using concordance index (C-index), area under receiver...
Acne treatment may fail or cause undesirable side effects due to inaccurate evaluation. High-frequency ultrasound (HFUS) can monitor systemic in patients with moderate-to-severe acne vulgaris.In this prospective study, consecutive vulgaris were recruited. Patients graded by a comprehensive clinical assessment before and after therapy. Simultaneous HFUS grading was independently evaluated according the sonographic scoring system for (SSSA). Clinical grades compared through kappa analysis.A...
Abstract Background: The 70-gene signature (70-GS, MammaPrint) test has been recommended by the main guidelines to evaluate prognosis and chemotherapy benefit of hormonal receptor positive human epidermal 2 negative (HR+/Her2-) early breast cancer (BC). However, this expensive assay is not always accessible affordable worldwide. Based on our previous study, we established nomogram models predict binary quartile categorized risk 70-GS. Methods: We retrospectively analyzed a consecutive cohort...