A5047090558- Photoacoustic and Ultrasonic Imaging
- Ultrasound and Hyperthermia Applications
- AI in cancer detection
- Breast Lesions and Carcinomas
- Rheumatoid Arthritis Research and Therapies
- Infrared Thermography in Medicine
- Radiomics and Machine Learning in Medical Imaging
- Thermography and Photoacoustic Techniques
- Global Cancer Incidence and Screening
- Optical Imaging and Spectroscopy Techniques
- Inflammatory Bowel Disease
- Inflammasome and immune disorders
- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Breast Cancer Treatment Studies
- Thermoregulation and physiological responses
- Air Quality Monitoring and Forecasting
- Toxoplasma gondii Research Studies
- Machine Learning and ELM
- Microscopic Colitis
- Ear and Head Tumors
- RNA Interference and Gene Delivery
- Immune Response and Inflammation
- Osteoarthritis Treatment and Mechanisms
- Venous Thromboembolism Diagnosis and Management
Ningxia Medical University
2024
Peking University Shenzhen Hospital
2023-2024
Jiangnan University
2024
Tianjin Research Institute of Electric Science (China)
2024
Peking Union Medical College Hospital
2017-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2023
Sun Yat-sen University
2023
Key Laboratory of Guangdong Province
2023
State Key Laboratory of Building Safety and Built Environment
2023
Nanjing Medical University
2023
We reported an initial clinical study of in vivo human thyroid by a photoacoustic/ultrasound handheld probe. Our dual-modality system is based on high-end ultrasound machine. Both healthy and cancerous thyroids were imaged non-invasively, we compared the photoacoustic imaging with color Doppler ultrasound. The results could reveal many blood vessels that not sensitive for demonstrated provide important complementary information traditional examination, which has great potential diagnosis.
Background Synovial hypoxia is a hallmark of rheumatoid arthritis (RA). Photoacoustic (PA) imaging, based on the use laser-generated US, can detect oxygenation status tissue in individuals with RA. However, large studies are lacking, few investigating correlation between and disease activity. Purpose To measure synovial participants RA by using multimodal PA US imaging system to determine imaging-measured oxygen saturation (SO2) Materials Methods In this prospective observational cohort...
To investigate the feasibility of a CAD system S-detect on database from single Chinese medical center.An experienced radiologist performed breast US examinations and made assessments 266 consecutive lesions in 227 patients. classified automatically dichotomous form. An in-training resident who was blind to both diagnostic results histological reviewed images afterward. The final were considered as gold standard. performances interrater agreements analyzed.A total focal (161 benign 105...
Objective The aim of the study is to explore potential value S-Detect for residents-in-training, a computer-assisted diagnosis system based on deep learning (DL) algorithm. Methods was designed as cross-sectional study. Routine breast ultrasound examinations were conducted by an experienced radiologist. ultrasonic images lesions retrospectively assessed five residents-in-training according Breast Imaging Report and Data System (BI-RADS) lexicon, dichotomic classification provided S-Detect....
To validate the feasibility of S-Detect, an ultrasound computer-aided diagnosis (CAD) system using deep learning, in enhancing diagnostic performance breast (US) for patients with opportunistic screening-detected lesions.Nine medical centers throughout China participated this prospective study. Asymptomatic US-detected masses were enrolled and received conventional US, strain elastography subsequently. The final pathological results are referred to as gold standard classifying mass....
Abstract Objectives We aimed to assess the clinical value of multimodal photoacoustic/ultrasound (PA/US) articular imaging scores, a novel method which can reflect micro-vessels and oxygenation level inflamed joints rheumatoid arthritis (RA). Methods Seven small were examined by PA/US system. A 0–3 scoring system was used semi-quantify PA power-Doppler (PD) signals, sums PD scores (PA-sum PD-sum scores) seven calculated. The relative oxygen saturation (SO 2 ) values measured classified into...
Deep learning-based computer-aided diagnosis (CAD) is an important method in aiding for radiologists. We investigated the accuracy of a deep CAD classifying breast lesions with different histological types.A total 448 were detected on ultrasound (US) and classified by experienced radiologist, resident respectively. The pathological results chosen as golden standard. diagnostic performances three raters types analyzed.For overall performance, presented significantly higher specificity...
We examined 14 benign and 26 malignant breast nodules by a handheld dual-modal PA/US imaging system analyzed the data using quantitative semi-quantitative method. The PA signal spatial density scores of different regions were compared, diagnostic performances two methods based on parameters evaluated. For both results, significant differences in distributions signals lesions identified. showed good performance diagnosing cancer, indicating potential PAI clinical utilization.
Owing to the heavy health burdens from rheumatoid arthritis, a sensitive and objective imaging method is needed for early diagnosis accurate evaluation of disease. We aimed fabricate vascular epithelial growth factor (VEGF)–targeted microbubbles (MBs) evaluate expression levels VEGF within inflammatory lesions rats with adjuvant-induced arthritis (AIA) using multimodal photoacoustic (PA)/ultrasound (US) system. Fluorescein isothiocyanate–biotin double-labeled endothelial receptor 2...
Abstract In this pilot study, we explored a quantitative method to analyse characteristics of breast tumours using 3D volumetric data obtained from three-dimensional (3D) photoacoustic/ultrasound (PA/US) functional imaging system. Imaging results 24 Asian patients with maximum tumour diameters less than 2 cm, including 8 benign tumours, 16 T1 stage invasive cancers (IBCs), and 22 normal breasts, were analysed. We found that the mean oxygenation saturation (SO ) in regions IBCs was 7.7% lower...
A growing body of experimental and clinical evidence has implicated gut microbiota in the onset course rheumatoid arthritis (RA). The imbalance intestinal flora RA patients may lead to abnormal expression immune cells related cytokines.
Aggressive angiomyxoma (AAM) is a rare tumour that often occurs in soft tissues of the female genital tract. Eight cases AAM are reported this article, and clinical features ultrasound magnetic resonance imaging (MRI) results eight reviewed summarized. The main complaints all patients were palpable painless masses vulva or scrotum. lesions mainly located vulva, pelvis, perineal region, with large scope involvement. sonographic characteristic. On sonography, irregular shape showed...
To develop a nomogram for predicting axillary lymph node (ALN) metastases using the breast imaging reporting and data system (BI-RADS) ultrasound lexicon.A total of 703 patients from July 2015 to January 2018 were included in this study as primary cohort model construction. Moreover, 109 including 51 pathologically confirmed N1 (TNM staging) 58 non-metastatic recruited an external validation March August 2019. Ultrasound images clinical information these retrospectively reviewed. The...
Multiple objective assessments have been used to assess the activity of keloids compare different therapeutic regimens and facilitate best individual treatment choice for patients, but none them are standardized. A multimodal photoacoustic/ultrasonic (PA/US) imaging system, including photoacoustic imaging, elastography, ultra-micro-angiography, conventional US technologies (gray scale US, color Doppler power US), was applied evaluate by a radiologist. Growing stages were defined Vancouver...
This study aimed to identify features of breast intraductal lesions in photoacoustic/ultrasound (PA/US) imaging and compare PA/US with color Doppler flow/ultrasound (CDFI/US) the evaluation lesions. In nine patients 10 8 benign lesions, total vessel scores evaluated from are significantly greater than those CDFI/US (p=0.005). PA internal oxygen saturation (SO 2 ) score increased (p=0.016, p=0.006). With a cutoff (sum SO score) 2.5, we obtained sensitivity 90% specificity 87.5%...
Abstract Objectives We aimed to investigate the value of deep learning (DL) models based on multimodal ultrasonographic (US) images quantify RA activity. Methods Static greyscale (SGS), dynamic (DGS), static power Doppler (SPD) and (DPD) US were collected evaluated by two expert radiologists according EULAR–OMERACT Synovitis Scoring system. Four DL developed ResNet-type structure, separate test cohorts, finally compared with performance 12 different levels experience. Results In total, 1244...
Purpose: The purpose of this study was to compare the diagnostic performance breast lesions between deep learning-based computer-aided diagnosis (deep CAD) system and experienced radiologists symptomatic asymptomatic patients. Methods: From January December 2018, a total 451 in 389 consecutive patients were examined (mean age 46.86±13.03 years, range 19-84 years) by both ultrasound CAD system, all which biopsied, pathological results obtained. diagnosed an radiologist according fifth edition...
Photoacoustic imaging (PAI) was performed to evaluate oxygen saturation ( s O 2 ) of blood-mimicking phantoms, femoral arteries in beagles, and radial humans at various plateaus. The accuracy (root mean square error, RMSE) PAI compared with reference calculated. In achieved an 1.49% a absolute error (MAE) 1.09% within 25 mm depth, good linearity (R = 0.968; p < 0.001) obtained between . canine arteries, 2.16% MAE 1.58% 8 depth 0.965; 0.001). human 3.97% 3.28% from 4 14 0.892; For...