Xuelan Li

ORCID: 0000-0001-9110-1103
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Research Areas
  • Pregnancy and preeclampsia studies
  • Maternal and fetal healthcare
  • Birth, Development, and Health
  • Assisted Reproductive Technology and Twin Pregnancy
  • Reproductive Biology and Fertility
  • Ovarian function and disorders
  • Gestational Diabetes Research and Management
  • Reproductive System and Pregnancy
  • Biological and pharmacological studies of plants
  • Maternal and Perinatal Health Interventions
  • MicroRNA in disease regulation
  • Photoacoustic and Ultrasonic Imaging
  • Cardiovascular Issues in Pregnancy
  • Pregnancy and Medication Impact
  • Endometriosis Research and Treatment
  • Prenatal Screening and Diagnostics
  • Bariatric Surgery and Outcomes
  • Soil Geostatistics and Mapping
  • Essential Oils and Antimicrobial Activity
  • Plant and Fungal Species Descriptions
  • Reproductive Health and Technologies
  • Geochemistry and Geologic Mapping
  • Ectopic Pregnancy Diagnosis and Management
  • Ginger and Zingiberaceae research
  • Nutrition and Health in Aging

Southern Medical University
2017-2025

The First People's Hospital of Shunde
2022-2025

First Affiliated Hospital of Xi'an Jiaotong University
2010-2024

Nanjing University of Information Science and Technology
2023-2024

Chinese Academy of Medical Sciences & Peking Union Medical College
2007-2023

Xi'an Jiaotong University
2012-2023

Peking Union Medical College Hospital
2022-2023

Zunyi Normal College
2023

Third Affiliated Hospital of Sun Yat-sen University
2021

Sun Yat-sen University
2021

To evaluate the value of fasting plasma glucose (FPG) in first prenatal visit to diagnose gestational diabetes mellitus (GDM).Medical records 17,186 pregnant women attending clinics 13 hospitals China, including Peking University First Hospital (PUFH), were examined. Patients with pre-GDM excluded; data for FPG at and one-step GDM screening 75-g oral tolerance test (OGTT) performed between 24 28 weeks gestation collected analyzed.The median ± SD was 4.58 0.437. decreased increasing age....

10.2337/dc12-1157 article EN cc-by-nc-nd Diabetes Care 2012-11-29

Abstract In mammals, nonrenewable primordial follicles are activated in an orderly manner to maintain the longevity of reproductive life. Mammalian target rapamycin (mTOR)-KIT ligand (KITL) signaling pre-granulosa cells and phosphatidylinositol 3-kinase (PI3K)-protein kinase B (Akt)-forkhead Box O3a (FOXO3a) oocytes important for follicle activation. The activation process is accompanied by enhancement energy metabolism, but causal relationship unclear. present study, levels...

10.1038/s41419-022-04541-1 article EN cc-by Cell Death and Disease 2022-01-27

Lead is known to have toxic effects on the cardiovascular system. Owing its high concentration, transmission range, and absorption efficiency in organisms, inhalation of fine particulate matter (PM2.5)-bound lead (PM2.5-Pb) may cause significant damage. However, contribution adverse PM2.5-Pb workers residents non-ferrous metal smelting areas are not fully understood. In this work, concentration chemical speciation were analyzed determine pollution characteristics at a typical site. A panel...

10.1021/acs.est.2c07476 article EN cc-by Environmental Science & Technology 2023-01-23

Premature ovarian failure (POF), a frequently occurring pathology. Chrysin has antioxidant, anti-inflammatory, anti-apoptotic and other pharmacological activities. This study was designed to detect the effect of on POF. The establishment POF depended subcutaneous injection D-gal (200 mg/kg/d). With adoption ELISA, levels hormones release inflammatory cytokines were assayed. expression MDA, GSH-px, SOD ROS evaluated with corresponding kits. In addition, pathological changes ovary apoptosis...

10.1080/21655979.2021.2005991 article EN Bioengineered 2022-03-21

The aim of the present study was to characterize role microRNA (miR)-155 in pathogenesis severe preeclampsia (PE). A total 19 preeclampsic and 22 normal placentas were collected measure miR-155 endothelial nitric oxide synthase (eNOS) expression using quantitative (q)PCR western blot analysis. results demonstrated a significant increase levels decreased eNOS placentas, as compared with controls. In order examine function human placenta, HTR8/Svneo cell line transiently transfected an mimic...

10.3892/mmr.2014.2214 article EN Molecular Medicine Reports 2014-05-06

Background Synovial hypoxia is a hallmark of rheumatoid arthritis (RA). Photoacoustic (PA) imaging, based on the use laser-generated US, can detect oxygenation status tissue in individuals with RA. However, large studies are lacking, few investigating correlation between and disease activity. Purpose To measure synovial participants RA by using multimodal PA US imaging system to determine imaging-measured oxygen saturation (SO2) Materials Methods In this prospective observational cohort...

10.1148/radiol.212257 article EN Radiology 2022-08-23

Soil nutrients are an important component of soil fertility, and having accurate timely information is conducive to scientifically guided agricultural fertilization improved crop yields. Traditional nutrient measurement methods but time-consuming costly. Visible near-infrared (vis-NIR) mid-infrared (MIR) as techniques spectroscopy measurements cheap, fast, non-destructive, and, after training, have been used separately predict nutrients. They can give complementary information, so using them...

10.1016/j.geoderma.2023.116754 article EN cc-by Geoderma 2023-12-19

The aim of this study was to establish a method for discriminating Dendrobium officinale from four its close relatives chrysanthum, crystallinum, aphyllum and devonianum based on chemical composition analysis. We analyzed 62 samples 24 species. High performance liquid chromatography analysis confirmed that the low molecular weight compounds 4',5,7-trihydroxyflavanone (naringenin), 3,4-dihydroxy-4',5-dime-thoxybibenzyl (DDB-2), 3',4-dihydroxy-3,5'-dimethoxybibenzyl (gigantol),...

10.1007/s11427-012-4419-3 article EN cc-by Science China Life Sciences 2012-12-01

To a large extent, the ovarian reserve determines woman's reproductive potential. The etiological and pathological mechanisms of diminished (DOR) remain unclear, no reliable treatment is currently available for DOR. Adipokines cytokines in follicular fluid (FF) play pivotal roles development maturation. concentrations adipokines FF from individual follicles women with DOR undergoing vitro fertilization (IVF) were studied. In particular, we investigated associations between levels FFs...

10.1186/s13048-025-01594-6 article EN cc-by-nc-nd Journal of Ovarian Research 2025-01-22

Endocrine-disrupting chemicals (EDCs), particularly phthalates (PAEs), bisphenols, parabens, and polycyclic aromatic hydrocarbons (PAHs), constitute pervasive environmental contaminants with demonstrated potential to adversely affect female reproductive health. Although these compounds are known exert adverse effects, critical knowledge gaps persist concerning their specific associations outcomes. The present study analyzed 144 follicular fluid samples from women undergoing assisted...

10.20517/jeea.2025.07 article EN Journal of Environmental Exposure Assessment 2025-05-16

INTRODUCTION Gestational diabetes mellitus (GDM) was earlier defined as "hyperglycemia first recognized during pregnancy" and has more recently been described by American Diabetes Association (ADA) (2012) diagnosed pregnancy that is not clearly overt diabetes.[1] The hyperglycemia adverse outcomes study (HAPO) demonstrated the risk of maternal, fetal, neonatal continuously increase a function maternal glycemia at 24−28 weeks, even within ranges previously considered normal for pregnancy.[2]...

10.4103/0366-6999.147858 article EN cc-by-nc-nd Chinese Medical Journal 2014-12-26

To evaluate effectiveness and safety of titrated oral misoprostol solution (OMS) in comparison with vaginal dinoprostone for cervix ripening labor induction term pregnant women. A multicenter randomized controlled trial women singleton pregnancy indications induction; 481 participants were allocated to receive OMS different doses by hourly administration according the procedure or insert compare maternal outcomes including indication induction, mode outcome delivery, morbidity, neonatal...

10.1007/s00404-015-4000-y article EN cc-by Archives of Gynecology and Obstetrics 2016-01-08

Background With the refinement of cryopreservation technology, number frozen-warmed embryo transfer (FET) cycles and cryopreserved embryos has increased rapidly. However, studies investigating effect storage duration on pregnancy outcomes after vitrification are limited their results controversial. Furthermore, available did not take patients’ demographic nor clinical treatment characteristics into account cryo-storage was short. So this study aimed to explore vitrified warmed neonatal in...

10.3389/fendo.2023.1148411 article EN cc-by Frontiers in Endocrinology 2023-03-14

The effect of hepatitis B immunoglobulin (HBIG) on virus (HBV) DNA load and its protective mechanism are not well understood. Twenty-eight surface antigen (HBsAg)–positive pregnant women their newborns were assigned to an experimental (n = 12) or control group 16) according whether they received HBIG during pregnancy. HBV markers titer the mothers tested. These in did fluctuate significantly comparable control. In group, there was a positive correlation between with regard antibody titer....

10.1080/21645515.2015.1010890 article EN Human Vaccines & Immunotherapeutics 2015-06-30

The aim of our study was to compare the clinical characteristics fetal and neonatal outcomes in twin pregnancies between women with preeclampsia (PE) those normotension a Chinese population. There were 143 preeclamptic 367 normotensive included this retrospective case–control study. baseline perinatal collected compared groups. Multiple logistic regression linear used assess correlations PE outcomes. Significant increases observed frequencies preterm delivery (OR = 2.75, P < 0.001),...

10.1097/md.0000000000005199 article EN cc-by-nc Medicine 2016-10-01

Photoacoustic imaging (PAI) was performed to evaluate oxygen saturation ( s O 2 ) of blood-mimicking phantoms, femoral arteries in beagles, and radial humans at various plateaus. The accuracy (root mean square error, RMSE) PAI compared with reference calculated. In achieved an 1.49% a absolute error (MAE) 1.09% within 25 mm depth, good linearity (R = 0.968; p &lt; 0.001) obtained between . canine arteries, 2.16% MAE 1.58% 8 depth 0.965; 0.001). human 3.97% 3.28% from 4 14 0.892; For...

10.1364/boe.469747 article EN cc-by Biomedical Optics Express 2022-09-19

Pregnancy complicated with pulmonary arterial hypertension (PAH) is a severe and dangerous condition for both the mother fetus. Pregnancy-specific alterations in maternal cardiovascular system suggest that PAH pregnancy may manifest more symptoms compared those non-pregnant patients. Although most societal guidelines recommend early termination case of PAH, some recent data suggests mortality among patients lower than previously observed if woman decides to proceed pregnancy, she should be...

10.1016/j.ijcrp.2024.200252 article EN cc-by-nc-nd International Journal of Cardiology Cardiovascular Risk and Prevention 2024-03-17

Homeobox genes are known to be critically important in tumor development and progression.The BP1 (Beta Protein 1) gene, an isoform of DLX4, belongs the Distal-less (DLX) subfamily homeobox encodes a homeodomain-containing transcription factor.Our studies have shown that gene was overexpressed 81% primary breast cancer its expression closely correlated with progression cancer.However, exact role has yet elucidated.Therefore, it is explore potential transcriptional targets via whole...

10.7150/ijbs.5.1 article EN cc-by-nc International Journal of Biological Sciences 2009-01-01
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