A5100378610- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis Viruses Studies and Epidemiology
- HIV/AIDS Research and Interventions
- Liver Disease and Transplantation
- Cytomegalovirus and herpesvirus research
- Viral Infections and Outbreaks Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Herpesvirus Infections and Treatments
- Substance Abuse Treatment and Outcomes
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Maternal Mental Health During Pregnancy and Postpartum
- Food Security and Health in Diverse Populations
- PARP inhibition in cancer therapy
- Autophagy in Disease and Therapy
- Pancreatic and Hepatic Oncology Research
- Biochemical and Structural Characterization
- Smoking Behavior and Cessation
- Virus-based gene therapy research
- Youth Development and Social Support
- Liver Diseases and Immunity
- Cutaneous lymphoproliferative disorders research
- Heme Oxygenase-1 and Carbon Monoxide
Huazhong University of Science and Technology
2010-2025
Tongji Hospital
2025
Qilu Hospital of Shandong University
2024
First Affiliated Hospital of Xi'an Jiaotong University
2013-2024
Southwest Medical University
2020-2023
Xi'an Medical University
2023
Army Medical University
2023
Southwest Hospital
2023
Sichuan University
2023
Eighth Affiliated Hospital of Sun Yat-sen University
2023
Chronic hepatitis B (CHB) and liver fibrosis are associated with a high risk of hepatocellular carcinoma (HCC) development. We assessed whether entecavir (ETV) plus Biejia-Ruangan compound (BRC), an anti-fibrotic traditional Chinese medicine, can further reduce the HCC in treatment-naïve patients CHB Ishak score ≥3 points derived from our parent double-blind randomized placebo-controlled trial.After 72-week comparison between ETV+BRC ETV+placebo treatment, participants were eligible to enter...
Hepatocellular carcinoma ( HCC ) is the second most common cause of cancer‐related mortality worldwide. The expression nitric oxide synthase NOS and inhibition autophagy have been linked to cancer cell death. However, involvement serum NO ), not investigated in . In present study, we first established that level was significantly higher hepatitis B virus‐related than liver cirrhosis control (53.60 ± 19.74 vs 8.09 4.17 μmol/L, t = 15.13, P < 0.0001). Using immunohistochemistry, found...
Journal Article Tobacco control policy and adolescent cigarette smoking status in the United States Get access Maria T. Botello-Harbaum, Botello-Harbaum Search for other works by this author on: Oxford Academic PubMed Google Scholar Denise L. Haynie, Haynie Ronald J. Iannotti, Iannotti Jing Wang, Wang Lauren Gase, Gase Bruce Simons-Morton Nicotine & Research, Volume 11, Issue 7, July 2009, Pages 875–885, https://doi.org/10.1093/ntr/ntp081 Published: 14 May 2009 history Received: 11 September...
Abstract Background and Aim The efficacy of telbivudine for breaking vertical transmission hepatitis B virus has been well established. Data on the risk postpartum flare after withdrawal extended antiviral therapy delivery are limited. Methods Chronic virus‐infected women who received beginning at week 24 or 28 gestation were enrolled then followed up to 52 weeks postpartum. Virological biochemical parameters assessed. Results Of 241 finished follow‐up, 33.6% had elevated serum alanine...
Long-term nucleos(t)ide analogue (NA) treatment can reverse liver fibrosis in chronic hepatitis B (CHB), but its effect on regression remains limited. Biejia-Ruangan (BR) has been approved China as an antifibrotic traditional Chinese medicine drug patients with diseases. A multicenter randomized controlled trial aims to evaluate the of BR CHB treated NAs.CHB histologically confirmed advanced or cirrhosis were randomly assigned receive entecavir (ETV) (0.5 mg per day) plus (2 g 3 times a...
Both enantiomers of cyclohexenylguanine were synthesized in a stereospecific way starting from the same material: R-(−)-carvone. compounds showed potent and selective anti-herpesvirus activity (HSV-1, HSV-2, VZV, CMV). The binding both cyclohexene nucleosides active site HSV-1 thymidine kinase was investigated, model for is proposed. amino acids involved optical antipodes are same, but interaction energy slightly different. This may be attributed to secondary hydroxyl function nucleoside...
Hepatocellular carcinoma (HCC) is one of the most frequent malignant tumors in world. The only serological marker widely used for diagnosis HCC alpha-fetoprotein (AFP). Despite that AFP HCC, it has a limit as due to its low sensitivity and specificity. human cervical cancer proto-oncogene 1 (HCCR-1) was previously reported new biomarker HCC. To further evaluate HCCR-1 we conducted prospective cohort study. We evaluated significance simultaneous measurement 2 tumor markers China, Japan Korea....
Abstract Background & Aims We previously found that hepatic stellate cell activation induced by autophagy maintains the liver architecture to prevent collapse during acute failure. Nitric oxide has shown induce apoptosis. Whether and how nitric is involved in failure remains unclear. Methods Acute patients were recruited investigate correlation between plasma levels clinical features. Liver tissues collected from chronic hepatitis biopsy who had undergone transplantation. The expression...
INTRODUCTION: Little reliable evidence has been reported regarding usefulness of liver stiffness measurement (LSM) for monitoring the hepatic fibrosis changes during treatment. We aimed to assess association between in LSM and histological outcomes patients with chronic hepatitis B. METHODS: In this prospective multicenter study, 727 treatment-naive receiving entecavir-based therapy, who underwent paired biopsies at treatment baseline week 72, were analyzed. Changes defined as ≥30% decrease,...
BackgroundHBeAg-positive chronic infection is a unique phase of hepatitis B virus (HBV) infection. Current guidelines advise against starting antiviral treatment for HBeAg-positive patients, some data suggest treating such patients may reduce the risk hepatocellular carcinoma. We aimed to explore whether these can have evident histological liver injury (EHLI), and develop non-invasive model identifying EHLI in patients.MethodWe assessed HBV defined by Ishak fibrosis stage ≥3 and/or...
Botulinum neurotoxin (BoNT) is a highly lethal toxin produced by the anaerobic bacterium Clostridium botulinum, which leads to nerve paralysis following poisoning. At present, there no specific drug officially approved. Antibodies, particularly single-domain antibodies, represent safe and effective candidates for drugs against BoNT. In this study, receptor-binding domain of botulinum (BoNT/AHCC) was utilized immunize Bactrian camels, resulting in generation nanobody phage library. From...
To investigate the roles of mutations in enhancer II (Enh II) and basal core promoter (BCP) hepatitis B virus (HBV) hepatocellular carcinoma (HCC), we determined sequence Enh II/BCP 152 HCC 136 non-HCC patients from a high-incidence area East China. A longitudinal study was conducted on 21 cases which serial plasma samples were available before HCC. In total, six point mutations, including T1653, V1753, T1762, A1764, T1766 A1768, found to occur more frequently patients. Multivariate analysis...
The AnluoHuaxian pill (AHP) is a widely used patented medicine for chronic hepatitis B (CHB) patients with advanced fibrosis or cirrhosis that has been in China more than 15 years. However, data are lacking on whether monotherapy AHP can be effective CHB alanine aminotransferase (ALT) levels less 2 times the upper limit of normal (ALT<2ULN) and early liver (F ≤ 2). We aimed to investigate improves histology these patients. In this double-blind, randomized, placebo-controlled trial, 270...
Abstract Background Neither HBV DNA nor HBsAg positivity at birth is an accurate marker for infection of infants. No data available continuous changes markers in newborns to HBsAg(+) mothers. This prospective, multi-centers study aims observing the dynamic and exploring early diagnostic mother-infant infection. Methods One hundred forty-eight mothers their were enrolled after signed informed consent forms. Those infants received combination immunoprophylaxis (hepatitis B immunoglobulin...