A5051594298- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Viral Infections and Outbreaks Research
- Galectins and Cancer Biology
- Diabetes and associated disorders
- Immune Response and Inflammation
- Cancer Research and Treatments
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Viral Infections and Vectors
- Cancer Cells and Metastasis
- Monoclonal and Polyclonal Antibodies Research
- Macrophage Migration Inhibitory Factor
- Hepatitis B Virus Studies
- Systemic Lupus Erythematosus Research
- Viral gastroenteritis research and epidemiology
- Complement system in diseases
- Pancreatitis Pathology and Treatment
- Inflammatory Bowel Disease
- Cancer-related molecular mechanisms research
- Viral Infectious Diseases and Gene Expression in Insects
- Psoriasis: Treatment and Pathogenesis
- Viral Infections and Immunology Research
- Cytokine Signaling Pathways and Interactions
Academy of Military Medical Sciences
2012-2024
Inner Mongolia Medical University
2013-2024
National Institutes for Food and Drug Control
2023-2024
Institute of Pharmacology
2023-2024
Chinese PLA General Hospital
2021-2024
University of the Witwatersrand
2024
China Earthquake Administration
2022
Central South University
2013-2021
Tianjin Hospital
2021
China Pharmaceutical University
2021
Interleukin‐12 family cytokines have emerged as critical regulators of immunity with some members (IL‐12, IL‐23) associated disease pathogenesis while others (IL‐27, IL‐35) mitigate autoimmune diseases. Each IL‐12 member is comprised an α and a β chain, chain‐sharing key feature. Although four bona fide thus far been described, promiscuous chain‐pairing between alpha (IL‐23p19, IL‐27p28, IL‐12/IL‐35p35) beta (IL‐12/IL‐23p40, IL‐27/IL‐35Ebi3) subunits, predicts six possible heterodimeric...
Sepsis is an excessive inflammatory condition with a high mortality rate and limited prediction therapeutic options. In this study, for the first time, to our knowledge, we found that downregulation and/or blockade of T cell Ig mucin domain protein 3 (Tim-3), negative immune regulator, correlated severity sepsis, suggesting Tim-3 plays important roles in maintaining homeostasis sepsis both humans mouse model. Blockade led increased macrophage activation, which contributed systemic response...
T cell Ig mucin-3 (Tim-3), an immune checkpoint inhibitor, shows therapeutic potential. However, the molecular mechanism by which Tim-3 regulates responses remains to be determined. In particular, very little is known about how works in innate cells. Here, we demonstrated that involved development of tumor-promoting M2 macrophages colon cancer. Manipulation pathway significantly affected polarization status intestinal and progression The signaling was explored using microarray,...
Abstract Chronic inflammation is a major driving force for the development of colitis-associated cancer (CAC). Elevated production granulocyte macrophage colony-stimulating factor (GM-CSF) has been observed in mucosa patients with inflammatory bowel disease. Its actions progression from colitis to cancer, however, remain poorly understood. Herein, we demonstrated that colonic epithelial cells (CEC) were cellular source GM-CSF and its was significantly augmented when CAC model established by...
Abstract This study tested the hypothesis that besides spleen, LNs, peripheral blood, and thymus contain a regulatory IL-10-producing CD19+CD5+CD1dhigh B cell subset may play critical role in maintenance of immune homeostasis. Indeed, this population was identified murine thymus, furthermore, when cocultured with CD4+ T cells, cells supported CD4+Foxp3+ Tregs vitro, part, via CD5–CD72 interaction. Mice homozygous for Cd19Cre (CD19−/−) express impaired signaling humoral responses. Strikingly,...
Alternative splicing (AS) of mRNA is known to be involved in regulation immune cell differentiation and activation. Elongation factor Tu GTP binding domain containing 2 (Eftud2) an AS potentially modulate innate response macrophages. In this study, we investigate its involvement the pathogenesis colitis-associated cancer (CAC). Using established mouse model CAC, show that Eftud2 constantly overexpressed colonic tissues as well infiltrating Myeloid-specific knockout remarkably suppresses...
Regulatory IL-10-producing CD1d(high)CD5(+)CD19(+) B cells and CD4(+)CD25(+)Foxp3(+) T have been found to modulate immune responses in autoimmunity, infection, cancer, but the interaction between these two cell subsets remains unclear. Through culture flow cytometry (FACS), we analyzed of regulatory (Tregs) (Bregs). A neutralizing antibody was used determine role CD5 CD72 maintaining homeostasis. We that CD19(+)CD5(+)CD1d(hi) Bregs induced expansion CD4(+)Foxp3(+) Tregs, CD4(+)CD25(+) Tregs...
Abstract Growing evidence shows that granulocyte macrophage colony-stimulating factor (GM-CSF) has progression-promoting potentials in certain solid tumors, which is largely attributed to the immunomodulatory function of this cytokine tumor niches. However, little known about effect GM-CSF on cancer cells. Herein, we show chronic exposure colon cells GM-CSF, harbor its receptor, leads occurrence epithelial mesenchymal transition (EMT), time and dose-dependent manners. These GM-CSF-educated...
Abstract The development of multidrug resistance ( MDR ) not only actively transports a wide range cytotoxic drugs across drug transporters but is also complex interaction between number important cellular signalling pathways. Nitric oxide donors appear to be new class anticancer therapeutics for satisfying all the above conditions. Previously, we reported furoxan‐based nitric oxide‐releasing compounds that exhibited selective antitumour activity in vitro and vivo . Herein, demonstrate...
Botulinum neurotoxin (BoNT) is a highly lethal toxin produced by the anaerobic bacterium Clostridium botulinum, which leads to nerve paralysis following poisoning. At present, there no specific drug officially approved. Antibodies, particularly single-domain antibodies, represent safe and effective candidates for drugs against BoNT. In this study, receptor-binding domain of botulinum (BoNT/AHCC) was utilized immunize Bactrian camels, resulting in generation nanobody phage library. From...
Complement 5a (C5a) and Interleukin-17 (IL-17) are two important inflammatory mediators in sepsis. Here we studied the mechanisms underlying regulation of IL-17 by anaphylatoxin C5a. We found that C5a blockade increased survival rate mice following cecal ligation puncture (CLP)-induced sepsis decreased expression vivo. was secreted mainly gammadelta T cells this model. Importantly, our data suggest participates secretion cells. Dendritic (DC) were to act as a "bridge" between mechanism...
Summary Whether interleukin (IL)‐17 promotes a diabetogenic response remains unclear. Here we examined the effects of neutralization IL‐17 on progress adoptively transferred diabetes. IL‐17‐producing cells in non‐obese diabetic (NOD) mice were identified and their role pathogenesis diabetes using transfer co‐transfer assays. Unexpectedly, found that vivo did not protect NOD–severe combined immunodeficiency (SCID) against by splenocytes. In NOD mice, γδ + T dominated to be major source IL‐17....
Tumor necrosis factor-α (TNF-α) is a key factor for the pathogenesis of inflammatory bowel diseases (IBD), whose function known to be mediated by TNF receptor 1 (TNFR1) or 2. However, precise role two receptors in IBD remains poorly understood. Herein, acute colitis was induced dextran sulfate sodium (DSS) instillation TNFR1 2−/− mice. ablation led exacerbation signs colitis, including more weight loss, increased mortality, colon shortening and oedema, severe intestinal damage, higher levels...
Abstract T cell immunoglobulin mucin-3 (Tim-3) is an immune checkpoint inhibitor and its dysregulation has been related to tolerance many disorders, such as tumors infection tolerance. However, the physiopathology roles of Tim-3 in innate immunity remain elusive. Here, we demonstrate that inhibits macrophage phagocytosis L. monocytogenes by inhibiting nuclear erythroid 2-related factor 2 (Nrf2) signaling pathway increases bacterial burden. promotes Nrf2 degradation increasing ubiquitination...
Marburg virus (MARV) is one of the filovirus species that cause deadly hemorrhagic fever in humans, with mortality rates up to 90%. Neutralizing antibodies represent ideal candidates prevent or treat disease. However, no antibody has been approved for MARV treatment date. In this study, we identified a novel human named AF-03 targeted glycoprotein (GP). possessed high binding affinity GP and showed neutralizing protective activities against pseudotyped vitro vivo. Epitope identification,...
Tolerance induction of autoreactive T cells against pancreatic beta cell-specific autoantigens such as glutamic acid decarboxylase 65 (GAD65) and insulin has been attempted a method to prevent autoimmune diabetes. In this study, we investigate whether adenoassociated virus (AAV) gene delivery multiple immunodominant epitopes expressing GAD(500-585) could induce potent immune tolerance persistently suppress diabetes in NOD mice. A single muscle injection 7-wk-old female mice with...