A5103211259- Robotic Mechanisms and Dynamics
- RNA Research and Splicing
- RNA modifications and cancer
- Air Quality and Health Impacts
- Circadian rhythm and melatonin
- Liver Disease Diagnosis and Treatment
- Toxic Organic Pollutants Impact
- Inflammasome and immune disorders
- RNA and protein synthesis mechanisms
- Gynecological conditions and treatments
- Adipose Tissue and Metabolism
- Ovarian function and disorders
- Plant tissue culture and regeneration
- Reproductive Biology and Fertility
- Soft Robotics and Applications
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Modular Robots and Swarm Intelligence
- Electrocatalysts for Energy Conversion
- Fluid Dynamics and Heat Transfer
- Sarcoidosis and Beryllium Toxicity Research
- Corrosion Behavior and Inhibition
- Advanced battery technologies research
- Birth, Development, and Health
- Healthcare and Venom Research
- Advanced Surface Polishing Techniques
Beijing Jiaotong University
2013-2025
Shanghai University of Medicine and Health Sciences
2025
Fujian Medical University
2021-2024
Union Hospital
2024
Third Affiliated Hospital of Sun Yat-sen University
2024
Sun Yat-sen University
2020-2024
East China University of Science and Technology
2024
Shenzhen Luohu People's Hospital
2024
Fudan University
2018-2023
Zhongshan Hospital
2023
Koichi Ogami1,4, Patricia Richard1, Yaqiong Chen1, Mainul Hoque2, Wencheng Li2, James J. Moresco3, John R. Yates III3, Bin Tian2 and L. Manley1 1Department of Biological Sciences, Columbia University, New York, York 10027, USA; 2Department Microbiology, Biochemistry, Molecular Genetics, Rutgers Jersey Medical School, Newark, 07103, 3Department Chemical Physiology, The Scripps Research Institute, La Jolla, California 92037, USA Corresponding author: jlm2{at}columbia.edu ↵4 Present address:...
Abstract Although food availability is a potent synchronizer of the peripheral circadian clock in mammals, underlying mechanisms are unclear. Here, we show that hepatic Bmal1, core transcription activator molecular clock, post-transcriptionally regulated by signals from insulin, an important hormone temporally controlled feeding. Insulin promotes postprandial Akt-mediated Ser42-phosphorylation Bmal1 to induce its dissociation DNA, interaction with 14-3-3 protein and subsequently nuclear...
In this paper, we present the design of a novel 3-RUS/RRR redundantly actuated parallel mechanism for ankle rehabilitation based on principle from conceptual design. The proposed can actualize rotational movements in three directions while at same time center rotations match axes compared with other multi-degree-of-freedom devices, owing to structural characteristics special constraint limb and platform. A new actuator redundancy scheme is used, which not only still maintains all inherent...
The nuclear RNA exosome is an essential and versatile machinery that regulates maturation degradation of a huge plethora species. past two decades have witnessed remarkable progress in understanding the whole picture its substrates structural basis functions. In addition to itself, recent studies focusing on associated co-factors been elucidating how directed towards specific substrates. Moreover, it has gradually realized loss-of-function subunits affect multiple biological processes, such...
Abstract The molecular targets and mechanisms of propolis ameliorating metabolic syndrome are not fully understood. Here, we report that Brazilian green reduces fasting blood glucose levels in obese mice by disrupting the formation CREB/CRTC2 transcriptional complex, a key regulator hepatic gluconeogenesis. Using mammalian two-hybrid system based on CREB-CRTC2, identify artepillin C (APC) from as an inhibitor CREB-CRTC2 interaction. Without apparent toxicity, APC protects high fat...
Emerging evidence implies a key role of angiopoietin-like protein 8 (Angptl8) in the metabolic transition between fasting and feeding, whereas much less is known about mechanism its own expression. Here we show that hepatic Angptl8 rhythmically expressed, which involving liver X receptor alpha (LXRα) glucocorticoid (GR) modulation during feeding periods, respectively. In addition, mRNA very unstable, contributes to nature daily rhythmicity by rapidly responding fasting/feeding transition. To...
Decline in successful conception decreases more rapidly after 38 years of age owing to follicular depletion and decreased oocyte quality. However, limited information is available regarding the underlying mechanism useful treatment. This study aimed evaluate effects growth hormone supplementation on maturation vivo aged young mice determine its effect mitochondrial function. The influence three different doses recombinant human (rhGH) (0.4, 0.8 1.6 mg/kg/day) for 8 weeks before ovarian...
Abstract Growing evidence shows that granulocyte macrophage colony-stimulating factor (GM-CSF) has progression-promoting potentials in certain solid tumors, which is largely attributed to the immunomodulatory function of this cytokine tumor niches. However, little known about effect GM-CSF on cancer cells. Herein, we show chronic exposure colon cells GM-CSF, harbor its receptor, leads occurrence epithelial mesenchymal transition (EMT), time and dose-dependent manners. These GM-CSF-educated...
The human gut is a reservoir of antibiotic resistance genes (ARGs). Even in the absence antibiotics, ARGs are present large quantities faeces adults, children and even newborns. However, where when acquired remains unclear, as does types acquired. Herein, we recruited 82 pairs women their caesarean section Conventional culture methods quantitative PCR were employed to detect nine species six ARG meconia, from 3-day-old newborns, amniotic fluid, colostrum, hospital ward air samples....
Abstract The aim of the study was to identify specific clinical and serum protein biomarkers that are associated with longitudinal outcome RA-associated interstitial lung disease (RA-ILD). 60 RA patients serological profiles were assessed by HRCT pulmonary function tests (PFTs) at baseline (Year 0) 5 years post enrollment 5). Progression versus non-progression defined based on changes in Quantitative Modified scores PFTs over time. Specific samples Year Multiplex enzyme-linked immunosorbent...
Exoskeletons play a crucial role in joint healthcare by providing targeted support and rehabilitation for individuals with musculoskeletal diseases. As an assistive device, the accurate monitoring of user’s signals exoskeleton status using wearable sensors is essential to ensure efficiency conducting complex tasks various scenarios. However, balancing sensitivity stretchability devices applications remains significant challenge. Here, we introduce strain sensor detecting finger knee motions....
Flexible electronic skin has garnered significant interest due to its promising applications in underwater robotics, aircraft monitoring systems, and human healthcare systems. A critical requirement for flexible is exhibit high sensitivity, stretchability, stability. Functional materials, as essential components of skin, significantly influence the overall performance device. Consequently, a variety material structural designs have been developed enhance functional materials. This...
Abstract Objectives The aim of this study was to investigate serum biomarkers linked primary Sjögren's syndrome (pSS)-associated interstitial lung disease (ILD). Methods 69 pSS patients were consecutively enrolled and evaluated via quantitative ILD scoring based on high-resolution computed tomography (HRCT). Biomarkers interest assessed by multiplex enzyme-linked immunosorbent assays (ELISAs). Results Among with pSS, the presence pSS–ILD 50% radiographically defined abnormalities (ILA)...
The extensive use of chemical/inorganic fertilizer application over the past few decades has significantly enhanced global food production potentials. However, excessive these fertilizers resulted in environmental issues, soil nutrient imbalances, and poor quality food. study aimed to evaluate impact various blends bio-organic fertilizer, farm manure, compound on health, focusing content, enzymatic parameters, physio-biochemical attributes, traits tobacco. experimental treatments...