A5081687805- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Immune cells in cancer
- MicroRNA in disease regulation
- Mathematical Biology Tumor Growth
- Cancer-related molecular mechanisms research
- Bioinformatics and Genomic Networks
- Circular RNAs in diseases
- Histone Deacetylase Inhibitors Research
- interferon and immune responses
- Metabolism, Diabetes, and Cancer
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- PI3K/AKT/mTOR signaling in cancer
- Cancer Immunotherapy and Biomarkers
- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
- Ubiquitin and proteasome pathways
- Liver Disease Diagnosis and Treatment
- RNA Research and Splicing
- Diet, Metabolism, and Disease
- Protease and Inhibitor Mechanisms
Nanjing Medical University
2015-2025
Weifang People's Hospital
2025
Hangzhou Medical College
2017-2025
Zhejiang Provincial People's Hospital
2025
Jiangsu Province Hospital
2014-2024
Qingdao University
2011-2024
Jiangsu Cancer Hospital
2019-2024
Harbin Medical University
2014-2024
First Affiliated Hospital of Harbin Medical University
2014-2024
Nanjing Drum Tower Hospital
2018-2024
MiR-145 can regulate cell apoptosis, proliferation, neural development and stem differentiation. Previous studies indicate that miR-145 is downregulated in human colon cancer cells. However, the molecular mechanisms of used to carcinogenesis angiogenesis remain be clarified. Here, we show expression ovarian tissues lines. inhibits p70S6K1 post-transcriptional by binding its 3'-UTR. The angiogenic factors hypoxia-inducible factor 1 (HIF-1) vascular endothelial growth (VEGF), which are...
Dysregulation of microRNAs is a common feature in human cancers, including breast cancer (BC). Here we describe the epigenetic regulation miR-148a and miR-152 their impact on BC cells. Due to hypermethylation CpG island, expression levels both (miR-148a/152) are decreased tissues DNMT1, DNA methyltransferase 1 for maintenance methylation, aberrantly up-regulated its overexpression responsible promoters. Intriguingly, found that DNMT1 expression, which one targets miR-148a/152, inversely...
Phosphofructokinase 1 (PFK1) plays a critical role in glycolysis; however, its and regulation tumorigenesis are not well understood. Here, we demonstrate that PFK1 platelet isoform (PFKP) is the predominant human glioblastoma cells expression correlates with total PFK activity. We show PFKP overexpressed specimens due to an increased stability, which induced by AKT activation resulting from phosphatase tensin homologue (PTEN) loss EGFR-dependent PI3K activation. binds phosphorylates at S386,...
PD-L1 up-regulation in cancer contributes to immune evasion by tumor cells. Here, we show that Wnt ligand and activated EGFR induce the binding of β-catenin/TCF/LEF complex CD274 gene promoter region expression, which AKT activation plays an important role. β-Catenin depletion, inhibition, or PTEN expression reduces cells, enhances infiltration CD8+ T growth, accompanied prolonged mouse survival. Combined treatment with a clinically available inhibitor anti–PD-1 antibody overcomes greatly...
Abstract Isocitrate dehydrogenase (IDH) wild-type glioblastoma (GBM) has a dismal prognosis. A better understanding of tumor evolution holds the key to developing more effective treatment. Here we study GBM's natural evolutionary trajectory by using rare multifocal samples. We sequenced 61,062 single cells from eight IDH primary GBMs and defined signature (NES) tumor. show that NES significantly associates with activation transcription factors regulate brain development, including MYBL2...
MicroRNAs are a class of small noncoding RNAs that function as critical gene regulators through targeting mRNAs for translational repression or degradation. In this study, we showed miR-128 expression levels were decreased in glioma, and identified p70S6K1 novel direct target miR-128. Overexpression suppressed its downstream signaling molecules such HIF-1 VEGF expression, attenuated cell proliferation, tumor growth angiogenesis. Forced can partly rescue the inhibitory effect cells. Taken...
Colorectal cancer (CRC) is one of the leading cancer-related causes death in world. Recently, downregulation microRNA-143 (miR-143) has been observed CRC tissues. Here this study, we found that miR-143 expression was downregulated both patients' blood samples and tumor specimens. MiR-143 levels were strongly correlated with clinical stages lymph node metastasis. Furthermore, insulin-like growth factor-I receptor (IGF-IR), a known oncogene, novel direct target miR-143, whose inversely human...
// Lin Wang 1,* , Zhu-mei Shi 1,2,* Cheng-fei Jiang Xue Liu 1 Qiu-dan Chen Xu Qian Dong-mei Li Xin Ge Xie-feng 2 Ling-Zhi 3 Yong-ping You Ning and Bing-Hua 1,3 State Key Lab of Reproductive Medicine, Department Pathology, Nanjing Medical University, Nanjing, China Neurosurgery, The First Affiliated Hospital Anatomy Cell Biology, Thomas Jefferson Philadelphia, USA * These authors contributed equally to this work Correspondence: Jiang, email: Liu, Keywords : miR-143, N-RAS, tumor growth,...
MicroRNAs (miRNAs) have been shown to be involved in different aspects of cancer biology including tumor angiogenesis. In this study, we identified that two miRNAs, miR-199a and miR-125b were downregulated ovarian tissues cell lines. Overexpression inhibited tumor-induced angiogenesis associated with the decrease HIF-1α VEGF expression cells. Moreover, levels negatively correlated mRNA tissues. We further showed direct targets HER2 HER3 functionally relevant. Forced rescued miR-199a-...
Glioma is one of the most aggressive and lethal human brain tumors. Accumulating evidence shows that microRNAs play important roles in cancers, including glioma. Previous studies reported miR-124 levels were downregulated glioma specimens. Here, we further investigate potential role The expression detected specimens by quantitative reverse transcriptase PCR. direct targets identified bioinformatics analysis validated immunoblotting luciferase reporter assay. effects on cell proliferation...
Abstract Although food availability is a potent synchronizer of the peripheral circadian clock in mammals, underlying mechanisms are unclear. Here, we show that hepatic Bmal1, core transcription activator molecular clock, post-transcriptionally regulated by signals from insulin, an important hormone temporally controlled feeding. Insulin promotes postprandial Akt-mediated Ser42-phosphorylation Bmal1 to induce its dissociation DNA, interaction with 14-3-3 protein and subsequently nuclear...