A5090780734- Glioma Diagnosis and Treatment
- Immune cells in cancer
- Mathematical Biology Tumor Growth
- Bioinformatics and Genomic Networks
- Mitochondrial Function and Pathology
- RNA modifications and cancer
- interferon and immune responses
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Histone Deacetylase Inhibitors Research
- Cardiovascular Function and Risk Factors
- Adipose Tissue and Metabolism
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Extracellular vesicles in disease
- Sirtuins and Resveratrol in Medicine
- RNA Research and Splicing
- Lipid metabolism and biosynthesis
- Cancer-related gene regulation
- Cardiovascular Disease and Adiposity
- Chemokine receptors and signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Cell Function and Interaction
Nanjing Medical University
2021-2025
Jiangsu Province Hospital
2021-2025
Air Force Medical University
2018-2024
Second Xiangya Hospital of Central South University
2020-2024
Tang Du Hospital
2022-2024
Central South University
2020-2024
Shanghai Clinical Research Center
2024
Fudan University
2023-2024
Huashan Hospital
2023-2024
Shanghai Center for Brain Science and Brain-Inspired Technology
2024
Increasing evidence has implicated the important role of mitochondrial pathology in diabetic cardiomyopathy (DCM), while underlying mechanism remains largely unclear. The aim this study was to investigate dynamics pathogenesis DCM and its mechanisms. Methods: Obese (db/db) lean control (db/+) mice were used study. Mitochondrial analyzed by transmission electron microscopy vivo confocal vitro. Results: Diabetic hearts from 12-week-old db/db showed excessive fission significant reduced...
Abstract Isocitrate dehydrogenase (IDH) wild-type glioblastoma (GBM) has a dismal prognosis. A better understanding of tumor evolution holds the key to developing more effective treatment. Here we study GBM's natural evolutionary trajectory by using rare multifocal samples. We sequenced 61,062 single cells from eight IDH primary GBMs and defined signature (NES) tumor. show that NES significantly associates with activation transcription factors regulate brain development, including MYBL2...
Acute myocardial infarction is a major health problem and the leading cause of death worldwide. Myocardial apoptosis induced by injury involved in pathophysiology heart failure. Therapeutic stem cell therapy has potential to be an effective favorable treatment for ischemic disease. Exosomes derived from cells have been shown effectively repair MI injury-induced cardiomyocyte damage. However, cardioprotective benefits adipose tissue-derived mesenchymal (ADSC)-Exos remain unknown. This study...
Abstract Glioblastoma (GBM) is a complex ecosystem that includes heterogeneous tumor population and the tumor-immune microenvironment (TIME), prominently containing tumor-associated macrophages (TAM) microglia. Here, we demonstrated β2-microglobulin (B2M), subunit of class I major histocompatibility (MHC-I), promotes maintenance stem-like neoplastic populations reprograms TIME to an anti-inflammatory, tumor-promoting state. B2M activated PI3K/AKT/mTOR signaling by interacting with PIP5K1A in...
Abstract Myocardial infarction (MI) is the leading cause of premature death among adults. Cardiomyocyte and dysfunction remaining viable cardiomyocytes are main pathological factors heart failure after MI. Mitochondrial complexes emerging as critical mediators for regulation cardiomyocyte function. However, precise roles mitochondrial complex subunits in MI remain unclear. Here, we show that NADH:ubiquinone oxidoreductase core subunit S1 (Ndufs1) expression decreased hearts patients mice...
Abstract The heart primarily derives its energy through lipid oxidation. In cardiomyocytes, lipids are stored in droplets (LDs) and utilized mitochondria, although the structural functional connections between these two organelles remain largely unknown. this study, visible evidence have presented indicating that a complex is formed at mitochondria‐LD membrane contact (MLC) site, involving mitochondrion‐localized Mfn2 LD‐localized Hsc70. This serves to tether mitochondria LDs, facilitating...
Background: This study searched for immune-related long noncoding RNAs (lncRNAs) to predict the prognosis of patients with cervical cancer. Method: We obtained immunologically relevant lncRNA expression profiles and clinical follow-up data from cancer The Cancer Genome Atlas database Molecular Signatures Database. Cervical were randomly divided into a training group, testing group combined group. immune prognostic signature was constructed by Least Absolute Shrinkage Selection Operator Cox...
Cardiac fibrosis is a leading cause of cardiac dysfunction in patients with diabetes. However, the underlying mechanisms remain unclear. This study aimed to investigate role long non-coding RNA (LncRNA) Airn pathogenesis diabetic cardiomyopathy (DCM) and its mechanism.Diabetes mellitus (DM) was induced mice by streptozotocin injection. An intramyocardial adeno-associated virus (AAV) used manipulate expression. The functional significance DCM were investigated both vitro vivo.Diabetic hearts...
Abstract Purpose: The dynamic interplay between glioblastoma stem cells (GSC) and tumor-associated macrophages (TAM) sculpts the tumor immune microenvironment (TIME) promotes malignant progression of (GBM). However, mechanisms underlying this interaction are still incompletely understood. Here, we investigate role CXCL8 in maintenance mesenchymal state GSC populations reprogramming TIME to an immunosuppressive state. Experimental Design: We performed integrative multi-omics analyses RNA...
Compromised mitophagy and mitochondrial homeostasis are major contributors for the etiology of cardiac aging, although precise underlying mechanisms remains elusive. Shank3, a heart-enriched protein, has recently been reported to regulate aging-related neurodegenerative diseases. This study aimed examine role Shank3 in pathogenesis senescence possible involved. Cardiac-specific conditional knockout (Shank3CKO) mice were subjected natural aging. Mitochondrial function activity determined...
Prioritization of disease mechanisms, biomarkers, and drug targets in immune-mediated inflammatory diseases (IMIDs) is complicated by altered interactions between thousands genes. Our multi-organ single-cell RNA sequencing a mouse IMID model, namely collagen-induced arthritis, shows highly complex heterogeneous expression changes all analyzed organs, even though only joints showed signs inflammation. We organized those into multicellular which predicted molecular within organs. That model...
Cardiac iron overload and ferroptosis greatly contribute to the poor prognosis of myocardial infarction (MI). Iron chelator is one most promising strategies for scavenging excessive alleviating cardiac dysfunction post MI. However, various side effects existing chemical chelators restrict their clinical application, which calls a more viable safer approach protect against injury in ischemic hearts. In this study, we isolated macrophage-derived extracellular vesicles (EVs) identified EVs as...
Sirt6 has been reported to play a protective role in macrophage foam cell formation, but whether controls atherosclerosis plaque stability and it can reduce the interaction between endothelial cells macrophages remains unclear. The aim of this study was investigate effect on underlying mechanisms. We used Tie2-Cre transgenic mice as Cre-lox tool delete floxed sequences during adulthood establish −/− mice. ApoE :Sirt6 :Sirt6Tg were our investigation. After 16 week high-fat diet, developed...
Background: Gastric cancer is one of the most common malignant tumors and has a poor prognosis. Hypoxia related to prognosis patients. We searched for hypoxia-related long noncoding RNAs (lncRNAs) predict both overall survival (OS) disease-free (DFS) gastric Methods: obtained lncRNA expression profiles clinical follow-up data patients with from The Cancer Genome Atlas (TCGA) Molecular Signatures Database (MSigDB). were randomly divided into training group, test group combined group....
A number of studies indicate that circular RNAs (circRNAs) play paramount roles in regulating the biological behavior glioblastoma multiforme (GBM). In this study, we investigated underlying mechanism circMELK GBM. Real-time PCRs were used to examine expression glioma tissues and normal brain (NBTs). Localization GBM cells was estimated by fluorescence <i>in situ</i> hybridization (FISH). Transwell migration three-dimensional invasion assays performed cell vitro</i>. Spheroid formation,...
Objectives Most studies have examined the association between serum copper and myocardial infarction, but there is little evidence of dietary intake infarction. Materials methods The study included a total 14,876 participants from 2011 to 2018 National Health Nutrition Examination Survey (NHANES). Multivariate logistic regression model was used analyze risk To reduce selection bias, we use nearest neighbor propensity score matching (PSM) in 1:2 ratio. Restricted cubic spline (RCS) method...
Abstract Lipid droplet (LD) accumulation is a notable feature of obesity-induced cardiomyopathy, while underlying mechanism remains poorly understood. Here we show that mice fed with high-fat diet (HFD) exhibited significantly increase in cardiac LD and RTN3 expression, accompanied by function impairment. Multiple loss- gain-of experiments indicate critical to HFD-induced accumulation. Mechanistically, directly bonds fatty acid binding protein 5 (FABP5) facilitate the directed transport...
The purpose of the present study was to explore aging‑associated cardiac dysfunction and possible mechanism by which swimming exercise modulates in aged mice. Aged mice were divided into two groups: i) mice; ii) subjected exercises. Another cohort 4‑month‑old male served as control group. Cardiac structure function analyzed using hematoxylin eosin staining, echocardiography. levels oxidative stress determined measuring superoxide dismutase, malondialdehyde reactive oxygen species (ROS)....
Multiple molecular mechanisms are involved in the development of heart failure (HF) after myocardial infarction (MI). However, interventions targeting these pathological processes alone remain clinically ineffective. Therefore, it is essential to identify new therapeutic targets for alleviating cardiac dysfunction MI. Here, gain- and loss-of-function approaches were used investigate role reticulon 3 (RTN3) HF We found that RTN3 was elevated myocardium patients with mice...