A5054120195- Mitochondrial Function and Pathology
- Cardiovascular Function and Risk Factors
- Adipose Tissue and Metabolism
- ATP Synthase and ATPases Research
- Cardiac Ischemia and Reperfusion
- Lipid metabolism and biosynthesis
- Cancer, Hypoxia, and Metabolism
Northwest University
2024
Chinese People's Armed Police Force
2024
Affiliated Zhongshan Hospital of Dalian University
2018-2019
Zhoushan Hospital
2018
Abstract Myocardial contractile dysfunction is associated with an increase in mitochondrial fission patients diabetes. However, whether directly promotes diabetes‐induced cardiac still unknown. Melatonin exerts a substantial influence on the regulation of fission/fusion. This study investigated melatonin protects against via fission/fusion and explored its underlying mechanisms. Here, we show that prevented by inhibiting dynamin‐related protein 1 (Drp1)‐mediated fission. treatment decreased...
Increasing evidence has implicated the important role of mitochondrial pathology in diabetic cardiomyopathy (DCM), while underlying mechanism remains largely unclear. The aim this study was to investigate dynamics pathogenesis DCM and its mechanisms. Methods: Obese (db/db) lean control (db/+) mice were used study. Mitochondrial analyzed by transmission electron microscopy vivo confocal vitro. Results: Diabetic hearts from 12-week-old db/db showed excessive fission significant reduced...
Abstract The heart primarily derives its energy through lipid oxidation. In cardiomyocytes, lipids are stored in droplets (LDs) and utilized mitochondria, although the structural functional connections between these two organelles remain largely unknown. this study, visible evidence have presented indicating that a complex is formed at mitochondria‐LD membrane contact (MLC) site, involving mitochondrion‐localized Mfn2 LD‐localized Hsc70. This serves to tether mitochondria LDs, facilitating...
We reported that alpha-ketoglutarate (α-KG) is indispensable for chronic hypoxia (CH)-induced cardiac remodeling, which builds the bridge between metabolic intermediates and remodeling.