A5060887873- Glioma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Mathematical Biology Tumor Growth
- RNA modifications and cancer
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Bioinformatics and Genomic Networks
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Quantum Information and Cryptography
- Cancer, Hypoxia, and Metabolism
- Quantum and electron transport phenomena
- Galectins and Cancer Biology
- Radiomics and Machine Learning in Medical Imaging
- Mitochondrial Function and Pathology
- Cancer Mechanisms and Therapy
- Neuroinflammation and Neurodegeneration Mechanisms
- Mechanical and Optical Resonators
- Covalent Organic Framework Applications
- interferon and immune responses
- Cancer Cells and Metastasis
Beijing Institute of Neurosurgery
2016-2025
Capital Medical University
2016-2025
Fuzhou University
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2025
Shanghai First Maternity and Infant Hospital
2025
Southwest Jiaotong University
2025
Shanghai University
2024
First Affiliated Hospital of GuangXi Medical University
2024
Guangxi Medical University
2024
Capital University
2023
Gliomas are the most common and malignant intracranial tumors in adults. Recent studies have revealed significance of functional genomics for glioma pathophysiological treatments. However, access to comprehensive genomic data analytical platforms is often limited. Here, we developed Chinese Glioma Genome Atlas (CGGA), a user-friendly portal storage interactive exploration cross-omics data, including nearly 2000 primary recurrent samples from cohort. Currently, open provided whole-exome...
N6-methyladenosine (m6A) RNA methylation, associated with cancer initiation and progression, is dynamically regulated by the m6A methylation regulators ("writers", "erasers" "readers"). Here, we demonstrate that most of thirteen main are differentially expressed among gliomas stratified different clinicopathological features in 904 gliomas. We identified two subgroups (RM1/2) applying consensus clustering to regulators. Compared RM1 subgroup, RM2 subgroup correlates a poorer prognosis,...
Abstract Preoperative MRI is one of the most important clinical results for diagnosis and treatment glioma patients. The objective this study was to construct a stable validatable preoperative T2-weighted MRI-based radiomics model predicting survival gliomas. A total 652 patients across three independent cohorts were covered in including their images, RNA-seq data. Radiomic features (1731) extracted from images 167 gliomas (discovery cohort) collected Beijing Tiantan Hospital then used...
Abstract Isocitrate dehydrogenase (IDH) wild-type glioblastoma (GBM) has a dismal prognosis. A better understanding of tumor evolution holds the key to developing more effective treatment. Here we study GBM's natural evolutionary trajectory by using rare multifocal samples. We sequenced 61,062 single cells from eight IDH primary GBMs and defined signature (NES) tumor. show that NES significantly associates with activation transcription factors regulate brain development, including MYBL2...
Patients with high ALDH1A3-expressing glioblastoma (ALDH1A3hi GBM) show limited benefit from postoperative chemoradiotherapy. Understanding the mechanisms underlying such resistance in these patients is crucial for development of new treatments. Here, we that interaction between ALDH1A3 and PKM2 enhances latter's tetramerization promotes lactate accumulation stem cells (GSCs). By scanning lactylated proteome lactate-accumulating GSCs, XRCC1 undergoes lactylation at lysine 247 (K247)....
Brain tumors are among the most challenging human for which mechanisms driving progression and heterogeneity remain poorly understood. We combined single-cell RNA-seq with multi-sector biopsies to sample analyze expression profiles of gliomas from 13 Chinese patients. After classifying individual cells, we generated a spatial temporal landscape glioma that revealed patterns invasion between different sub-regions gliomas. also used inferred copy number variations pseudotime trajectories...
Background: Researches on immunotherapy of glioma has been increasing exponentially in recent years. However, autoimmune-like side effects current immune checkpoint blockade hindered the clinical application glioma. The discovery TIM-3, a tumor-specific checkpoint, shed new light solution this dilemma. We aimed at investigating role TIM-3 transcriptome level and its relationship with practice glioma.Methods: A cohort 325 patients RNA-seq data from Chinese Glioma Genome Atlas (CGGA project)...
Glioblastoma is a paradigm of cancer-associated immunosuppression, limiting the effects immunotherapeutic strategies. Thus, identifying molecular mechanisms underlying immune surveillance evasion critical. Recently, preferential expression inhibitory natural killer (NK) cell receptor CD161 on glioma-infiltrating cytotoxic T cells was identified. Focusing molecularly annotated, large-scale clinical samples from different ethnic origins, data presented here provide evidence this modulator's...
Glioma is the most prevalent brain tumor, presenting with limited treatment options, while patients malignant glioma and glioblastoma (GBM) have poor prognoses. The physical obstacle to drug delivery imposed by blood‒brain barrier (BBB) stem cells (GSCs), which are widely recognized as crucial elements contributing unsatisfactory clinical outcomes. In this study, we found a small molecule, gambogic amide (GA-amide), exhibited ability effectively penetrate blood-brain displayed notable...
Abstract Aims This study aimed to investigate the role of plasmacytoma variant translocation 1 (PVT1), a long non‐coding RNA, in glioblastoma multiforme (GBM) and its impact on tumor microenvironment (TME). Methods We assessed aberrant PVT1 expression glioma tissues GBM cell growth vitro vivo. Additionally, we investigated PVT1's influencing glioma‐associated macrophages. To understand immunosuppressive TME, performed series comprehensive experiments. Results was overexpressed due copy...
Abstract Lipid metabolism reprogramming plays important role in cell growth, proliferation, angiogenesis and invasion cancers. However, the diverse lipid programmes prognostic value during glioma progression remain unclear. Here, metabolism‐related genes were profiled using RNA sequencing data from The Cancer Genome Atlas (TCGA) Chinese Glioma (CGGA) database. Gene ontology (GO) gene set enrichment analysis (GSEA) found that glioblastoma (GBM) mainly exhibited of glycosphingolipid metabolic...
// Fan Wu 1, 2, 8 , Chuanbao Zhang Jinquan Cai 3 Yang Tingyu Liang Xiaoyan Yan Haoyuan Wang 4 Wen 5 Jing Chen and Tao Jiang 6, 7, 1 Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beiijing, China 2 Molecular Neuropathology, Neurosurgical Institute, The Second Affiliated Hospital Harbin Harbin, Zhujiang Southern Guangzhou, Soochow Suzhou, 6 Center Brain Tumor, Institute for Disorders, 7 National Clinical Research Neurological Diseases, Chinese Glioma Genome...
Acidosis is a significant feature of the tumor microenvironment in glioma, and it closely related to multiple biological functions cancer stem cells. Here, we found that self-renewal ability, mitochondrial activity ATP production were elevated cell-like glioma cells (SLCs) under acidic microenvironment, which promoted maintained stemness SLCs. Under acidosis, 25-hydroxy vitamin D3-24-hydroxylase (CYP24A1) was upregulated catalyzed fast degradation 1α,25(OH)2D3. We further revealed active...
Abstract Gliomas are the most common and malignant intracranial tumours in adults. Recent studies have shown that functional genomics greatly aids understanding of pathophysiology therapy glioma. However, comprehensive genomic data analysis platforms relatively limited. In this study, we developed Chinese Glioma Genome Atlas (CGGA, http://www.cgga.org.cn ), a user-friendly portal for storage interactive exploration multi-dimensional includes nearly 2,000 primary recurrent glioma samples from...
Immune response mediated by macrophages is critical in tumor progression and implicates new targets potential efficient immunotherapies.Tumor associated (TAM) are divided into either polarized M1 or M2 phenotype depending on different regulators of polarization pro-or anti-oncogenic roles they play.Glioma-infiltrated TAMs have been newly reported contrary to the current dogma.Instead, glioma exhibit a continuum between M1-and M2-like TAM that resembling M0 macrophage.Here we proposed an OS...
O6methylguanine-DNA methyltransferase (MGMT) promoter methylation is a biomarker widely used to predict the sensitivity of IDH-wildtype glioblastoma temozolomide therapy. Given that IDH status has critical effects on survival and epigenetic features glioblastoma, we aimed assess role MGMT in IDH-mutant glioblastoma.This study included 187 glioblastomas 173 for comparison. Kaplan-Meier curves multivariate Cox regression were predictive effects.Compared with glioblastomas, showed significantly...
// Wen Wang 1, 2, 3, 7 , Fan Yang Lu Zhang 5 Jing Chen 4, Zheng Zhao Haoyuan 6, Wu Tingyu Liang Xiaoyan Yan Jiye Li 4 Qing Lan 2 Jiangfei Jizong 8 1 Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China The Second Affiliated Hospital Soochow Suzhou, 3 Molecular Neuropathology, Neurosurgical Institute, Ophthalmology, School Medicine, Shandong Jinan, 6 Zhujiang Southern Guangzhou, Chinese Glioma Cooperative Group (CGCG), National Clinical Research...
Abstract 1p/19q codeletion, which leads to the abnormal expression of 1p19q genes in oligodendroglioma, is associated with chemosensitivity and favorable prognosis. Here, we aimed explore clinical implications gene non-codel gliomas. We analyzed 668 gliomas obtained from The Cancer Genome Atlas (n = 447) Chinese Glioma 221) for training validation, respectively. was significantly correlated clinicopathological features overall survival Then, derived a risk signature 25 selected that not only...
Now, numerous exciting findings have been yielded in the field of energy metabolism within glioma cells. In addition to aerobic glycolysis, multiple catabolic pathways are employed for production. However, prognostic significance remains obscure. Here, we explored relationship between gene profile and outcome diffuse patients using The Cancer Genome Altas (TCGA) Chinese Glioma (CGGA) datasets. Based on expression profile, consensus clustering identified two robust clusters with distinguished...
Gliomas account for approximately 80% of primary malignant tumors in the central nervous system. Despite aggressive therapy, prognosis patients remains extremely poor. Glioma stem cells (GSCs) which considered as potential target therapy their crucial role therapeutic resistance and tumor recurrence, are believed to be key factors disappointing outcome. Here, we took advantage GSCs cell model perform high-throughput drug screening old antibiotic, clofoctol, was identified most effective...
Transcriptomic data derived from bulk sequencing have been applied to delineate the tumor microenvironment (TME) and define immune subtypes in various cancers, which may facilitate design of immunotherapy treatment strategies. We herein gathered published gene expression diffuse lower-grade glioma (LGG) patients identify subtypes. Based on profiles 402 LGG The Cancer Genome Atlas, we performed consensus clustering determine robust clusters patients, evaluated their reproducibility three...
Isocitrate dehydrogenase (IDH) wild-type diffuse lower-grade glioma (LGG) is usually associated with poor outcome, but there have been disputes over its clinical outcome and classification. We present here a robust gene expression-based molecular classification of IDH LGG into two subtypes distinct biological features. A discovery cohort 49 LGGs from the Chinese Glioma Genome Atlas (CGGA) was subjected to clustering function analysis. Seventy-three tumors The Cancer (TCGA) were used validate...