A5101698191- Complex Network Analysis Techniques
- Glioma Diagnosis and Treatment
- Advanced Graph Neural Networks
- Opinion Dynamics and Social Influence
- Network Security and Intrusion Detection
- Electrostatics and Colloid Interactions
- Surfactants and Colloidal Systems
- Mitochondrial Function and Pathology
- MicroRNA in disease regulation
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Big Data and Digital Economy
- Topological and Geometric Data Analysis
- Microfluidic and Bio-sensing Technologies
- Cancer Genomics and Diagnostics
- stochastic dynamics and bifurcation
- Pickering emulsions and particle stabilization
- Chromatin Remodeling and Cancer
- Cellular Mechanics and Interactions
Capital Medical University
2022-2024
Beijing Tian Tan Hospital
2022-2024
Huazhong University of Science and Technology
2022-2023
Fudan University
2013-2014
State Key Laboratory of Surface Physics
2013
Patients with high ALDH1A3-expressing glioblastoma (ALDH1A3hi GBM) show limited benefit from postoperative chemoradiotherapy. Understanding the mechanisms underlying such resistance in these patients is crucial for development of new treatments. Here, we that interaction between ALDH1A3 and PKM2 enhances latter's tetramerization promotes lactate accumulation stem cells (GSCs). By scanning lactylated proteome lactate-accumulating GSCs, XRCC1 undergoes lactylation at lysine 247 (K247)....
e19026 Background: Given the compromised immune systems of patients with CLL/SLL, there has always been concern about association between CLL/SLL-directed therapies and serious infection risks, prompting need for treatments lower risks. Using Symphony Health Solutions database, this real-world study described compared rates infections 12 18 months following initiation venetoclax + obinutuzumab (VO) zanubrutinib (zanu) in CLL/SLL. Methods: Patients diagnosed CLL/SLL who received VO from Apr...
The motility of the Dictyostelium discoideum (DD) cell is studied by video microscopy when cells are plated on top an agar plate at different densities, n. It found that fluctuating kinetics can be divided into two normal directions: cell's forward-moving direction and its direction. Along direction, slope amplitude fluctuation vs. velocity (R||(v)) increases with n, while along R⊥ independent Both R|| functions speed v. observed linearity in R⊥(v) indicated orientational (κ) DD a constant...
Can we employ one neural model to efficiently dismantle many complex yet unique networks? This article provides an affirmative answer. Diverse real-world systems can be abstracted as networks each consisting of functional nodes and edges. Percolation theory has indicated that removing only a few vital cause the collapse whole network. However, finding least number such is rather challenging task for large due its NP-hardness. Previous studies have proposed centrality measures heuristic...
BACKGROUND AND OBJECTIVES: Histopathological features and molecular biomarkers have been studied as potential prognostic factors. This study aimed to investigate the clinical features, phenotypes, survival prognosis of isocitrate dehydrogenase (IDH)-mutant (IDHmt) gliomas with histone H3 alterations (H3-alterations). METHODS: A total 236 657 patients whole-exome sequencing data were separately collected from Chinese Glioma Genome Atlas The Cancer databases. Survival analysis glioma was...
In this letter, we investigate the correlated diffusion of colloidal particles in quasi two-dimensional monolayer near an oil-water interface for different distance between and particle z. It is found that there a transition behavior from bulk dominated to with decreasing z or increasing inter-particle separation r. With scaling method proposed by us, can be scaled onto master curve which captures characters transition. The scale factors allow calculation z, are agreement one-particle measurements.
Percolation theory shows that removing a small fraction of critical nodes can lead to the disintegration large network into many disconnected tiny subnetworks. The dismantling task focuses on how efficiently select least such nodes. Most existing approaches focus measuring nodes' importance from either functional or topological viewpoint. Different theirs, we argue be measured both two complementary aspects: based competence in relaying information; While regional structural patterns. In...
Percolation theory shows that removing a small fraction of critical nodes can lead to the disintegration large network into many disconnected tiny subnetworks. The dismantling task focuses on how efficiently select least such nodes. Most existing approaches focus measuring nodes' importance from either functional or topological viewpoint. Different theirs, we argue be measured both two complementary aspects: based competence in relaying information; While regional structural patterns. In...
Diagnosis and treatment of patients with glioblastoma (GBM) who are also diagnosed primary non-central nervous system (CNS) tumors remain a challenge, yet little is known about the clinical characteristics prognosis these patients. The data presented here compared pathological features between or without non-CNS tumors, trying to further explore this complex situation.Statistical analysis was based on 45 were isocitrate dehydrogenase (IDH) wild-type accompanied by January 2019 February 2022...
Whether it be congestion control in cities or massive access the Internet, these dynamic behaviors can abstracted as flow demand between origin-destination node pairs (OD pairs) network. Links complex systems are with notable heterogeneity, which means volume of varies greatly, resulting some critical links being more likely to congest under attack, reducing service capability system, and even causing network collapses. To explore how dynamics influences functionality stability congestion,...