A5100401487- Immune cells in cancer
- Glioma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Galectins and Cancer Biology
- Mitochondrial Function and Pathology
- CAR-T cell therapy research
- Epigenetics and DNA Methylation
- HIV Research and Treatment
- Plant biochemistry and biosynthesis
- Cancer-related molecular mechanisms research
- Parkinson's Disease Mechanisms and Treatments
- Chromatography in Natural Products
- Renal Diseases and Glomerulopathies
- Restless Legs Syndrome Research
- Ginseng Biological Effects and Applications
- Autophagy in Disease and Therapy
- Pancreatitis Pathology and Treatment
- T-cell and B-cell Immunology
- Metabolomics and Mass Spectrometry Studies
- Immunotherapy and Immune Responses
- Ferroptosis and cancer prognosis
- Pharmacological Effects of Natural Compounds
Harbin Medical University
2025
Capital Medical University
2018-2025
Beijing Ditan Hospital
2020-2025
Beijing Tian Tan Hospital
2020-2025
Nanjing Traditional Chinese Medicine Hospital
2024
Changzhou No.2 People's Hospital
2024
Dalian Medical University
2024
Huzhou University
2024
Chengdu University of Traditional Chinese Medicine
2023
Inner Mongolia Medical University
2023
Background: Among the many immunosuppressive cells in tumor microenvironment, tumor-associated-macrophages (TAMs) are well known to contribute development. TAMs can be conditioned (polarized) transition between classical M1-like macrophages, or alternatively M2-like macrophages. Both regulated by signaling molecules microenvironment. secrete classic inflammatory cytokines that kill tumors promoting cell necrosis and immune infiltration into In contrast, exhibit powerful tumor-promoting...
Abstract Lung adenocarcinoma (LUAD) harboring EGFR mutations prevails in Asian population. However, the inter-patient and intra-tumor heterogeneity has not been addressed at single-cell resolution. Here we performed RNA sequencing (scRNA-seq) of total 125,674 cells from seven stage-I/II LUAD samples five tumor-adjacent lung tissues. We identified diverse cell types within tumor microenvironment (TME) which myeloid T were most abundant stromal tumors adjacent Within tumors, accompanied by an...
Patients with high ALDH1A3-expressing glioblastoma (ALDH1A3hi GBM) show limited benefit from postoperative chemoradiotherapy. Understanding the mechanisms underlying such resistance in these patients is crucial for development of new treatments. Here, we that interaction between ALDH1A3 and PKM2 enhances latter's tetramerization promotes lactate accumulation stem cells (GSCs). By scanning lactylated proteome lactate-accumulating GSCs, XRCC1 undergoes lactylation at lysine 247 (K247)....
Glioblastoma is a paradigm of cancer-associated immunosuppression, limiting the effects immunotherapeutic strategies. Thus, identifying molecular mechanisms underlying immune surveillance evasion critical. Recently, preferential expression inhibitory natural killer (NK) cell receptor CD161 on glioma-infiltrating cytotoxic T cells was identified. Focusing molecularly annotated, large-scale clinical samples from different ethnic origins, data presented here provide evidence this modulator's...
The efficacy and mechanisms of acupuncture for Crohn's disease (CD) are not well understood. We investigated its effects on symptoms, intestinal microbiota, circulating inflammatory markers in CD patients.This 48-week, randomized, sham controlled, parallel-group clinical trial was performed at a tertiary outpatient clinic China. From April 2015 to November 2019, 66 patients (mean age 40·4, 62·1% were male, all Han Chinese) with mild moderate active unresponsive drug treatment enrolled...
Renal interstitial fibrosis is the pathological basis of end-stage renal disease, in which heterogeneity macrophages microenvironment plays an important role. However, molecular mechanisms macrophage plasticity during progression remain unclear. In this study, we found for first time that increased expression Twist1 was significantly associated with severity IgA nephropathy patients and mice unilateral ureteral obstruction (UUO). Ablation markedly alleviated tubular injury UUO mice,...
Abstract Chimeric antigen receptor (CAR) T-cell therapy has demonstrated clinical response in treating both hematologic malignancies and solid tumors. Although instances of rapid tumor remissions have been observed animal models trials, relapses occur with multiple therapeutic resistance mechanisms. Furthermore, while the mechanisms underlying long-term are well-known, short-term adaptation remains less understood. However, more views shed light on hold that it provides an opportunity window...
The regulation of macrophage orientation pathological conditions is important but still incompletely understood. Here, we show that IL-10 and Rag1 double knockout mice spontaneously develop colitis with dominant M1 phenotype, suggesting regulates in inflammation. We demonstrate stimulation induced miR-146b expression, the expression was impaired deficient macrophages. Our data targets IRF5, resulting activation. Furthermore, developed intestinal inflammation enhanced polarization. Finally,...
Abstract Aims Gliomas are the primary malignant brain tumor and characterized as striking cellular heterogeneity intricate microenvironment (TME), where chemokines regulate immune cell trafficking by shaping local networks. This study aimed to construct a chemokine‐based gene signature evaluate prognosis therapeutic response in glioma. Methods In this study, 1024 patients (699 from TCGA 325 CGGA database) with clinicopathological information mRNA sequencing data were enrolled. A chemokine...
Glioblastoma is one of the most common neoplasms in central nervous system characterized by limited immune response and unlimited expansion capability. Cancer stem cells (GSCs), a small fraction tumor cells, possess pivotal regulation capability microenvironment with superior proliferation ability. We aimed to reveal interaction between glioma (GSCs) during tumorigenesis. Single-cell sequencing data from seven surgical specimens glioblastoma patients patient-derived GSCs co-cultured...
Mesoporous Fe
(1) Background: Glioblastoma multiforme (GBM) is the most common and malignant intracranial tumor in adults. At present, temozolomide (TMZ) recognized as preferred chemotherapeutic drug for GBM, but some patients have low sensitivity to TMZ or chemotherapy resistance TMZ. Our previous study found that GBM with EGFRvIII (+) However, reasons possible mechanisms of chemoradiotherapy are not clear. (2) Methods: In this study, tissue samples cell lines, glioma stem NSG mice were used explore...
Recent years have witnessed unprecedented strides in comprehending non-CD4 regulatory T cells (Tregs), such as CD8+ Tregs and double negative (DNT cells), their role sustaining immune tolerance restricting activation. This study investigates the of Foxp3+CD8+ during HIV infection assess markers associated with CD4+ Tregs. was designed a cross-sectional cohort study, comprising 21 age-matched healthy controls (HCs), 122 treatment-naïve participants (TNs), 60 people living (PLWH) receiving...
Abstract Aims We aimed to create a tumor recurrent‐based prediction model predict recurrence and survival in patients with low‐grade glioma. Methods This study enrolled 291 (188 the training group 103 validation group) clinicopathological information transcriptome sequencing data. LASSO‐COX algorithm was applied shrink predictive factor size build recurrent signature. GO, KEGG, GSVA analyses were performed for function annotations of The calibration curves C‐Index assessed evaluate...
Abnormal cellular respiration plays a critical role in carcinogenesis. However, the molecular mechanisms underlying dysregulation of respiratory gene expression across different cancer types remain unclear. Here, we developed computational framework that provides an analytical approach for exploring alterations and clinical relevance genes pan-cancer. We identified total 53 signatures three stages (including glycolysis, tricarboxylic acid cycle, oxidative phosphorylation) through this found...
BackgroundHuman oligodendroglioma presents as a heterogeneous disease, primarily characterized by the isocitrate dehydrogenase (IDH) mutation and 1p/19q co-deletion. Therapy development for this tumor is hindered incomplete knowledge of somatic driving alterations suboptimal disease classification. We herein aim to identify intrinsic molecular subtypes through integrated analysis transcriptome, genome methylome.Methods137 patients from Cancer Genome Atlas (TCGA) dataset were collected...
Macrophages have a defensive function against bacteria through phagocytosis and the secretion of cytokines. Histone modifications play an essential role in macrophage func-tions. Here, we report that Cxxc finger protein 1 (CFP1), key component SETD1 histone methyltransferase complex, promoted phagocytic bactericidal activity GM-CSF-derived macrophages. CFP1-deficient mice were more susceptible to bacterial infection due decreased expression Csf2rα, subunit GM-CSF receptor for inflammation...
The anomalous activation of glycolysis and subsequent accumulation L-lactate under aerobic conditions, known as the Warburg effect, are prominent metabolic hallmarks cancer[1][1]. Extensive research has revealed that lactate acts not only an energy-supplying substrate but also a
Aberrant DNA methylation patterns in leukemia might be exploited for therapeutic targeting. In this study, we employed a genetically deficient mouse model to explore the role of methylated binding protein MBD2 normal and malignant hematopoiesis. ablation led diminished lymphocytes. Functional defects lymphoid compartment were also observed after vivo reconstitution MBD2-deficient hematopoietic stem cells (HSC). an established Notch1-driven T-cell acute lymphoblastic (T-ALL), impeded...
A rapid, improved and comprehensive method including high-performance thin-layer chromatography, fingerprint technology single standard to determine multiple components was developed validated for the quality evaluation of licorice. In this study, a newly chromatography first used authentication licorice, which achieved simultaneous identification bands five known bioactive by comparing their retention factor values colors with standards. For analysis, 8 16 common peaks were identified....
Suan-Zao-Ren decoction has been used to treat insomnia for many years. In this work, a rapid and sensitive ultra-fast liquid chromatography with tandem mass spectrometry method was first developed fully validated the simultaneous quantification of seven main active components, spinosin, mangiferin, neomangiferin, ferulic acid, liquiritin, isoliquiritin, liquiritin apioside in rat plasma. The also successfully applied compare pharmacokinetics these ingredients after oral administration...
Abstract Background Poliovirus receptor interacts with 3 receptors: T-cell immunoglobulin immunoreceptor tyrosine-based inhibitory motif, CD96, and DNAX accessory molecule 1, which are predominantly expressed on T cells natural killer (NK) cells. Many solid tumors, including IDH wild-type glioblastoma, have been reported to overexpress poliovirus receptor, this overexpression is associated poor prognosis. However, there no preclinical or clinical trials investigating the use of cell-based...