A5047589359- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV, Drug Use, Sexual Risk
- Adolescent Sexual and Reproductive Health
- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- Polyomavirus and related diseases
- Tuberculosis Research and Epidemiology
- Syphilis Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Diagnosis and treatment of tuberculosis
- Family Caregiving in Mental Illness
- Pancreatitis Pathology and Treatment
- Hepatitis B Virus Studies
- Mental Health Treatment and Access
- Immune Cell Function and Interaction
- LGBTQ Health, Identity, and Policy
- Temporomandibular Joint Disorders
- HIV/AIDS oral health manifestations
- Herpesvirus Infections and Treatments
- Maternal Mental Health During Pregnancy and Postpartum
- Radiomics and Machine Learning in Medical Imaging
Capital Medical University
2016-2025
Beijing Ditan Hospital
2016-2025
Peking University
2022-2025
Hefei Institutes of Physical Science
2024
High Magnetic Field Laboratory
2024
Chinese Academy of Sciences
2024
Qufu Normal University
2024
Third Affiliated Hospital of Harbin Medical University
2021-2023
Harbin Medical University
2021-2023
China Geological Survey
2023
The administration of COVID-19 vaccines is the primary strategy used to prevent further infections by COVID-19, especially in people living with HIV (PLWH), who are at increased risk for severe symptoms and mortality. However, vaccine hesitancy, safety, immunogenicity among PLWH have not been fully characterized. We estimated hesitancy status vaccination Chinese PLWH, explored safety impact on antiviral therapy (ART) efficacy compared an inactivated between healthy controls (HC). In total,...
BackgroundTherapeutic approaches to HIV-suppressed immunological non-responders (INRs) remain unsettled. We previously reported efficacy of Chinese herbal Tripterygium wilfordii Hook F in INRs. Its derivative (5R)-5-hydroxytriptolide (LLDT-8) on CD4 T cell recovery was assessed.MethodsThe phase II, double-blind, randomized, placebo-controlled trial conducted adults patients with long-term suppressed HIV infection and suboptimal recovery, at nine hospitals China. The were 1:1:1 assigned...
In this qualitative study, 29 HIV-positive, Chinese patients reported highly favorable impressions of their healthcare providers, who were seen as providing important medical-related, financial, and emotional support. Generally, the patient-provider relationship positively impacted participants ability to maintain health was especially critical when isolated from familial sources support due intense AIDS stigma. Often family members informed an HIV diagnosis before patient, revealing...
Mitochondrial dysfunction has frequently been found in HIV-infected patients regardless of whether they received antiretroviral therapy (ART). Accumulating evidence suggests that exhibit marked changes mitochondrial membrane potential (MMP), reactive oxygen species (ROS) accumulation, adenosine triphosphate generation, mass (MM), DNA, etc. However, toxicity CD4T and CD8T cells caused by different levels HIV progression ART is poorly understood.Blood samples were obtained from 97 ART-naïve...
Abstract International health experts agree that China is on the verge of an AIDS crisis. In response, Chinese government initiated “Four Frees and One Care” policy in 2003 to decrease economic barriers increase access antiretroviral therapies for people with HIV. However, long-term treatment success requires not only access, but high rates medication adherence. This qualitative interview study 29 persons receiving HIV care at Beijing's Ditan Hospital identified facilitators The interviews...
Background Dolutegravir/lamivudine (DTG/3TC) is a recommended therapy regimen for hepatitis B surface antigen (HBsAg)-negative people living with HIV (PLWH) who have achieved virological suppression or are treatment-naïve. However, this may overlook the impact of occult infection on suppression, which mainly present as core antibody (HBcAb) positive but HBsAg negative. We aim to assess effect HBcAb positivity among PLWH had switched DTG/3TC.
Recent years have witnessed unprecedented strides in comprehending non-CD4 regulatory T cells (Tregs), such as CD8+ Tregs and double negative (DNT cells), their role sustaining immune tolerance restricting activation. This study investigates the of Foxp3+CD8+ during HIV infection assess markers associated with CD4+ Tregs. was designed a cross-sectional cohort study, comprising 21 age-matched healthy controls (HCs), 122 treatment-naïve participants (TNs), 60 people living (PLWH) receiving...
Mycobacterial infections represent a major cause of morbidity and mortality in HIV-infected individuals. This study evaluated diagnostic techniques for mycobacterial identification compared clinicopathological features between HIV-positive HIV-negative patients. We analyzed 88 tissue samples (with 41 matched blood 28 sputum samples) using histopathology (HE acid-fast staining), bacterial culture, MTB-PCR (sputum/biopsy), PCR-reverse dot blot hybridization (RDBH), metagenomic pathogen...
Few data are available on the outcomes of pediatric antiretroviral therapy (ART) in developing world.Eighty-three children were followed prospectively China from July 2005 to August 2006 and received (zidovudine or stavudine) plus lamivudine (nevirapine efavirenz).Fifty-one ART naive at enrollment, 32 experienced. After 12 months, median weight increased by 0.3 for age z-score, CD4 count 116 340 cells/mm (P < 0.0001), viral load decreased 5.53 <2.60 log10 copies/mL 0.0001) previously...
Cancer is responsible for elevated HIV-related morbidity and mortality. Research on HIV-infected patients with concurrent cancer rare in China. The purpose of our study was to investigate the prevalence risk factors associated among inpatients Beijing, mortality cancer. Hospital records from a total 1946 were collected Beijing Ditan Hospital. data, 2008 2013, retrospectively. diagnoses included AIDS-defining cancers (ADC) non-AIDS defining (NADC). Logistic regression used identify predicting...
Objective The study aimed to use supervised machine learning models predict the length and risk of prolonged hospitalization in PLWHs help physicians timely clinical intervention avoid waste health resources. Methods Regression were established based on RF, KNN, SVM, XGB hospital stay using RMSE, MAE, MAPE, R 2 , while classification NN, accuracy, PPV, NPV, specificity, sensitivity, kappa, visualization evaluation AUROC, AUPRC, calibration curves decision all used for internally validation....
Abstract Background In 2016, China has implemented the World Health Organization's “treat all” policy. We aimed to assess impact of significant improvements in 95-95-95 targets on population-level human immunodeficiency virus (HIV) transmission dynamics and incidence. Methods focused 3 steps HIV care continuum: diagnosed, antiretroviral therapy, achieving viral suppression. The molecular clusters were inferred using HIV-TRACE. New infections estimated incidence method European Centre for...
Abstract Background Efavirenz (EFV)-induced neuropsychiatric toxicity bothers people living with HIV (PLHIV). Neuropsychiatric adverse effects of EFV may differ by length time on EFV-based antiretroviral treatment (ART). Methods A cross-sectional, single-center study was conducted at Beijing Ditan Hospital in China from June–August 2020 among ART-experienced PLHIV who were long-term ART. 424 eligible virological suppressed participants enrolled and divided into four groups according to ART:...
chen w.‐t., shiu c.‐s., simoni j., fredriksen‐goldsen k., zhang f. & zhao h. (2010) Optimizing HIV care by expanding the nursing role: patient and provider perspectives. Journal of Advanced Nursing 66 (2), 260–268. Abstract Title. Aim. This paper is a report study conducted to explore healthcare services from perspectives both providers patients in order understand how optimize care. Background. In China, usually first diagnose general hospital. Then, HIV‐positive individuals are...
China is experiencing a rapid increase in the number of HIV-infected women. In this study, we describe development and preliminary evaluation an intervention tailored for Chinese women caregivers to improve their self- family management, with goals enhancing physical quality life (QOL) decreasing depressive symptomatology. Forty-one were recruited from two premier hospitals July 2014 through March 2016. Participants randomized either control or arm Self- Family Management Intervention...
Transmitted drug resistance (TDR) is a critical ongoing public health challenge in HIV/AIDS therapy. We explore the prevalence of TDR, its patterns, associated risk factors, and predicted sensitivity Beijing between 2015 2018.Retrospective data on TDR from 3265 antiretroviral therapy (ART)-naïve patients were collected at Ditan Hospital 1 August 2014 to 31 July 2018. was defined according Stanford Drug Resistance Mutations Database. prevalence, pattern, analysed.The overall HIV-1 6.68% (218...
Background The introduction of antiretroviral therapy (ART) has resulted in marked reductions morbidity among people living with HIV (PLWH). Monitoring the hospitalizations PLWH is important evaluating quality healthcare and forecasting co-morbidity pattern. We aimed to describe trends rates causes hospitalization who initiated ART an HIV-designated hospital China. Methods were hospitalized Beijing Ditan Hospital from 2008 2020 selected for study. Hospitalizations classified based on...
In China, the social stigma of both substance use and HIV remains major barriers. HIV+ individuals have been demonstrated to higher psychosocial distress in literature. To ensure quality life among Chinese individuals, self-efficacy HIV-related management including anxiety is key suppress viral load maintain healthy lives.We examine mediation relationship use, anxiety, self-management efficacy.A cross-sectional study design was used. 137 were recruited from two premier hospitals: Beijing's...
HIV-associated malignancies are responsible for morbidity and mortality increasingly in the era of potent antiretroviral therapy. This study aimed to investigate distribution among inpatients, immunodeficiency effect therapy (ART) on spectrum malignancies. A total 438 cases were enrolled from 2007 2020 Beijing Ditan Hospital. Demographic, clinical laboratory data, managements, outcomes collected analyzed retrospectively. Of cases, 433 assigned non-AIDS-defining cancers (NADCs) (n = 200,...