A5006080858- SARS-CoV-2 and COVID-19 Research
- Heat shock proteins research
- Aquaculture disease management and microbiota
- Genetic factors in colorectal cancer
- COVID-19 Clinical Research Studies
- Pregnancy and preeclampsia studies
- Calcium Carbonate Crystallization and Inhibition
- Bacteriophages and microbial interactions
- Fish Biology and Ecology Studies
- T-cell and B-cell Immunology
- Genetics, Aging, and Longevity in Model Organisms
- Colorectal Cancer Treatments and Studies
- Helicobacter pylori-related gastroenterology studies
- Glycosylation and Glycoproteins Research
- Molecular Biology Techniques and Applications
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- Immune Response and Inflammation
- Ubiquitin and proteasome pathways
- Birth, Development, and Health
- Reproductive biology and impacts on aquatic species
- Reproductive System and Pregnancy
- Aquaculture Nutrition and Growth
- Vibrio bacteria research studies
- Galectins and Cancer Biology
Jinan University
2012-2025
Capital Medical University
2025
Bioscience (China)
2025
Icahn School of Medicine at Mount Sinai
2012-2024
National University of Defense Technology
2024
Boston Children's Hospital
2024
Mount Sinai Hospital
2022-2024
St. Luke's-Roosevelt Hospital Center
2020-2023
Roosevelt Hospital
2023
City University of Hong Kong, Shenzhen Research Institute
2022
RORγt is necessary for the generation of TH17 cells but molecular mechanisms regulation are still not fully understood. We show that activation CD4+ T results in expression inducible nitric oxide synthase (iNOS). iNOS-deficient mice displayed enhanced cell differentiation without major effects on either TH1 or TH2 lineages, whereas endothelial NOS (eNOS) neuronal (nNOS) mutant showed comparable compared with wild-type control mice. The addition N6-(1-iminoethyl)-l-lysine dihydrochloride...
Folded single chain polymeric nano-objects are the molecular level soft material with ultra-small size. Here, we report an easy and scalable method for preparing single-chain nanogels (SCNGs) improved efficiency. We further investigate impact of dynamic conformational change SCNGs on cellular interactions from to bulk scale. First, supramolecular unfoldable efficiently deliver siRNAs into stem cells as a drug carrier in conformation-dependent manner. Furthermore, conformation changes enable...
Post-translational modifications have been identified to be of great importance in cancers and lysine acetylation, which can attract the multifunctional transcription factor BRD4, has as a potential therapeutic target. In this paper, we identify that BRD4 an important role colorectal cancer; its inhibition substantially wipes out tumor cells. Treatment with inhibitor MS417 potently affects cancer cells, although such effects were not always outright necrosis or apoptosis. We report also...
Abstract The long-term immunity and functional recovery after SARS-CoV-2 infection have implications in preventive measures patient quality of life. Here we analyzed a prospective cohort 121 recovered COVID-19 patients from Xiangyang, China at 1-year diagnosis. Among them, chemiluminescence immunoassay-based screening showed 99% (95% CI, 98–100%) seroprevalence 10–12 months infection, comparing to 0.8% 0.7–0.9%) the general population. Total anti-receptor-binding domain (RBD) antibodies...
ABSTRACT Evaluation of the Cobas 4800 test demonstrated that had a low rate cross-reactivity with low-risk human papillomavirus (lrHPV), 3.74% disconcordance between prealiquots and postaliquots, failure rates 4.57% 1.16%, respectively, after vortexing swirling. This study has good sensitivity, accuracy, reproducibility for detecting 14 high-risk HPV (hrHPV) genotypes.
The regulation of macrophage orientation pathological conditions is important but still incompletely understood. Here, we show that IL-10 and Rag1 double knockout mice spontaneously develop colitis with dominant M1 phenotype, suggesting regulates in inflammation. We demonstrate stimulation induced miR-146b expression, the expression was impaired deficient macrophages. Our data targets IRF5, resulting activation. Furthermore, developed intestinal inflammation enhanced polarization. Finally,...
A new artificial cell was capable of long-lived protein expression and supported gene regulation genetic oscillators.
Abstract Background The majority of human papillomavirus (HPV)‐related oropharyngeal carcinomas (OPCs) are associated with HPV genotype 16; however, OPC can be other high‐risk non‐HPV16 genotypes. Methods This was a retrospective analysis patients treated at single tertiary institution. Sociodemographic and clinical information obtained by chart review. determined polymerase chain reaction (PCR). Baseline data outcomes were compared between HPV16 groups. Results High‐risk genotypes accounted...
Peutz–Jeghers syndrome (PJS) is a rare hereditary disorder resulting from mutations in serine/threonine kinase 11 (STK11) and characterized by gastrointestinal (GI) hamartomatous polyps, mucocutaneous pigmentation, an increased risk for specific cancers. Little known about the genetic implications of STK11 with regard to their role dysplastic malignant transformation GI polyps. Peripheral blood genomic DNA samples 116 Chinese PJS patients 52 unrelated families were investigated mutations....
High-throughput proteomics has become an exciting field and a potential frontier of modern medicine since the early 2000s. While significant progress been made in technical aspects field, translating to clinical applications challenging. This review summarizes recent advances high-throughput discusses associated challenges, advantages, future directions. We focus on research breast cancer, bladder laryngeal squamous cell carcinoma, gastric colorectal coronavirus disease 2019. The application...
Chronic exposure to arsenic (As), a ubiquitous contaminant, poses deleterious health risks humans, including cardiovascular disease. Recent studies have implicated ferroptosis, in which the essential micronutrient selenium (Se) plays crucial role, several As-induced pathological processes. However, whether Se can counteract endothelial dysfunction through ferroptosis remains unclear. Herein, methylseleninic acid (MSA), methylselenium metabolite, was used as supplement investigate underlying...
Dynamic controlling the nanoscale presentation of synergistic ligands to stem cells by biomimetic single-chain materials can provide critical insights understand molecular crosstalk underlying and their extracellular matrix. Here, a stimuli-responsive macromolecular nanoregulator with conformational dynamics is fabricated based on an advanced scale-up single polymeric chain nanogel (SCNG). Such carefully designed SCNG capable mediating triggered copresentation master cryptic in molecule...