A5084072691- Hydrogels: synthesis, properties, applications
- Bone Tissue Engineering Materials
- Periodontal Regeneration and Treatments
- Electrospun Nanofibers in Biomedical Applications
- biodegradable polymer synthesis and properties
- Advanced Materials and Mechanics
- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Therapeutic Uses of Natural Elements
- Chemical Synthesis and Analysis
- Clay minerals and soil interactions
- Polymer Nanocomposite Synthesis and Irradiation
- Advanced Polymer Synthesis and Characterization
- Connective tissue disorders research
- Cellular Mechanics and Interactions
- Nanoparticle-Based Drug Delivery
- Silk-based biomaterials and applications
- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Advanced biosensing and bioanalysis techniques
- Polymer Surface Interaction Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Oral and gingival health research
- Nanoplatforms for cancer theranostics
- Click Chemistry and Applications
Southern Medical University
2022-2024
Guangzhou Medical University
2020-2023
State Key Laboratory of Respiratory Disease
2020-2023
Third Affiliated Hospital of Guangzhou Medical University
2020-2023
Chinese University of Hong Kong
2019-2020
Sun Yat-sen University
2012-2017
Folded single chain polymeric nano-objects are the molecular level soft material with ultra-small size. Here, we report an easy and scalable method for preparing single-chain nanogels (SCNGs) improved efficiency. We further investigate impact of dynamic conformational change SCNGs on cellular interactions from to bulk scale. First, supramolecular unfoldable efficiently deliver siRNAs into stem cells as a drug carrier in conformation-dependent manner. Furthermore, conformation changes enable...
Abstract Conductive cardiac patches have been proven to promote angiogenesis in infarcted myocardium; however, their conductive integrity, elasticity, and vascularization potential not yet optimized. The prevascularization of elastic could be an effective strategy for building a substantial connection between the patch heart. Here, coronary artery casting is introduced into holey graphene oxide/polypyrrole‐incorporated polyhydroxyethyl methacrylate prefabricated gel form vascularized patch....
Macroporous hydrogels offer physical supportive spaces and bio-instructive environment for the seeded cells, where cell-scaffold interactions directly influence cell fates subsequently affect tissue regeneration post-implantation. Effectively modifying bioactive motifs at inner pore surface provides appropriate niches interactions. A molecular imprinting method sacrificial templates are introduced to prepare modification in macroporous hydrogels. In detail, acrylated bisphosphonates (Ac-BPs)...
The potential translation of bio-inert polymer scaffolds as bone substitutes is limited by the lack neovascularization upon implantation and subsequently diminished ingrowth host bone, most likely resulted from inability to replicate appropriate endogenous crosstalk between cells. Human umbilical vein endothelial cell-derived decellularized extracellular matrix (HdECM), which contains a collection angiocrine biomolecules, has recently been demonstrated mediate cells(ECs) -...
ABSTRACT Depending upon the advantages of high efficiency, insensitivity to humidity and so on, reaction azide groups in glycidyl polymers (GAP) with alkynyl compounds has been used as a substitute urethane curing strategy develop GAP‐based binder for solid propellant. In this work, an compound dimethyl 2,2‐di(prop‐2‐ynyl)malonate (DDPM) reacted GAP produce new crosslinked materials under catalysis Cu(I)Cl at ambient temperature, showed great potential composite As feeding molar ratio DDPM...
The combination of diagnostic and therapeutic functions into a nano-carrier could achieve delivery system with both accurate diagnosis capabilities.
A series of biodegradable hydrogels based on oligo(2,2-dimethyltrimethylene carbonate)-block-poly(ethylene glycol)-block-oligo(2,2-dimethyltrimethylene carbonate) diacrylate (DPD-DA) precursor with varied length hydrophilic poly(ethylene glycol) (PEG) segment and hydrophobic (ODTC) were prepared by photopolymerization. Hydrophobic interaction was found to affect the properties hydrogel. The elastic modulus toughness hydrogel could be tuned altering lengths ODTC as well PEG segment. In a...
Adequate vascularization is crucial for the repair of bone defects. Platelet-derived growth factor-BB (PDGF-BB) has been shown to promote H-type vessel formation, a specialized blood vessel, strongly positive CD31 and endomucin, coupling angiogenesis osteogenesis. However, lack controllable factor delivery limits its clinical application, causing certain complications associated with PDGF-BB administration. This study developed an injectable heparin-conjugated hydrogel (GHH) controlled...
In recent years, with the rapid development of vitreo-retinal surgery for retinal diseases, vitreous substitutes are crucial adjuncts. To help maintain intactness intraocular structure, stable functionality, and proper pressure, an ideal substitute should possess physical biological properties similar to those natrual vitreous. This review discussed clinical application, advantages shortcomings commonly used substitutes, summarized research progress in experimental stage. particular,...