A5108445422- Bone Tissue Engineering Materials
- Hepatocellular Carcinoma Treatment and Prognosis
- Orthopaedic implants and arthroplasty
- Advanced Polymer Synthesis and Characterization
- 3D Printing in Biomedical Research
- Bacterial biofilms and quorum sensing
- RNA Interference and Gene Delivery
- Biopolymer Synthesis and Applications
- Orthopedic Infections and Treatments
- Graphene and Nanomaterials Applications
- Hydrogels: synthesis, properties, applications
- Nanoparticle-Based Drug Delivery
- Electrospun Nanofibers in Biomedical Applications
- Dendrimers and Hyperbranched Polymers
- Cellular Mechanics and Interactions
- Liver Disease and Transplantation
- Polymer Surface Interaction Studies
- High Entropy Alloys Studies
- Liver Disease Diagnosis and Treatment
- Microbial Fuel Cells and Bioremediation
- Silk-based biomaterials and applications
- Nanoparticles: synthesis and applications
- biodegradable polymer synthesis and properties
- High-Temperature Coating Behaviors
- Electrochemical sensors and biosensors
Jiangnan University
2021-2025
Beijing Chaoyang Emergency Medical Center
2025
Chongqing Medical University
2013-2025
Sun Yat-sen University
2015-2024
Capital Medical University
2024
State Key Laboratory of Optoelectronic Materials and Technology
2021-2023
Anhui Agricultural University
2022
Hunan University of Science and Technology
2022
Hebei North University
2022
Second Affiliated Hospital of Zhejiang University
2020-2021
Nano-delivery system has been widely studied and applied in cancer treatment over the past few decades. By taking advantage of both drug gene therapy, a growing number co-delivery systems have explored for recently.
Harnessing the inflammation and angiogenesis is extremely important in wound healing. In this study, we developed bioactive elastin-based hydrogels which can recruit modulate innate immune cells accelerate site subsequently improve regeneration. These were formed by visible-light cross-linking of acryloyl-(polyethylene glycol)-N-hydroxysuccinimide ester modified elastin with methacrylated gelatin, order to mimic dermal microenvironment. showed highly tunable mechanical properties, swelling...
We report the synthesis and characterization of interconnected macroporous network structures poly(ethylene glycol) (PEG) using cryogelation techniques. Novel monolithic networks containing a gradient pore size in layered fashion were created from single precursor by manipulating their polymerization kinetics. Maintaining conditions that promote rate gelation compared to nucleation ice crystals leads formation either conventional hydrogel-like or continuous heterogeneous layers cryogel-like...
To develop hydrogels with high mechanical strength for cell encapsulation and three-dimensional culture is a critical challenge cartilage tissue engineering. In this study, novel double network (DN) were fabricated phosphate buffer solution (PBS) was used as the solvent to facilitate encapsulation. The tough DN prepared through two-step photopolymerization using neutral oligo(2,2-dimethyltrimethylene carbonate)–poly(ethylene glycol)–oligo(2,2-dimethyltrimethylene carbonate)–diacrylate...
Bone-mimetic mineral-polymer composite materials have several applications ranging from artificial bone grafts to scaffolds for tissue engineering; templated mineralization is an effective approach fabricate such composites. In this study, we synthesized bone-like composites using synthetic hydrogels having pendant side chains terminating with carboxyl groups as a template mineralization. The role of matrix hydrophobicity on was examined poly(ethylene glycol) modified varying lengths anionic...
Many bacteria use signal molecules of low molecular weight to monitor their local population density and coordinate collective behavior in a process called "quorum sensing" (QS). N-acyl-homoserine lactones (AHLs) are the primary QS signals among Gram-negative bacteria. AHL-mediated plays an essential role diverse bacterial physiological processes. Recent evidence shows that plants able sense AHLs respond them appropriately. However, little is known about mechanism by which perceive transduce...
Osteomyelitis is a bone infection disease which caused by bacteria or other germs, and could cause serious impact on the health working capacity of patients. Alendronate (ALN) can chelate strongly with calcium ion hydroxyapatite (HA) commonly used to treat osteoporosis. Nanomedicine has attracted lot attention in that nano-sized carrier deliver drug molecules specific site interest aid targeting moiety achieve sustained release, resulting improved therapeutic effect reduced side effect. In...
Magnetite hybrid nanocomplexes are fabricated to eliminate bacteria and enhance biofilm disruption in the presence of a magnetic field.
Poly(disulfide)s-based systems with repetitive disulfide bonds in their backbones are emerging as promising tumor microenvironment responsive platforms for drug delivery. However, complicated synthesis and purification processes have restricted further application. Herein, we developed redox-responsive poly(disulfide)s (PBDBM) by one-step oxidation polymerization of a commercially available monomer, 1,4-butanediol bis(thioglycolate) (BDBM). PBDBM can self-assemble...
To establish a predictive model incorporating clinical features and contrast enhanced ultrasound liver imaging reporting data system (CEUS LI-RADS) for estimation of microvascular invasion (MVI) in hepatocellular carcinoma (HCC) patients.
The ASP composite scaffold promoted osteogenesis and inhibited osteoclastogenesis, which could serve as a bioactive material for bone regeneration of osteoporotic defects.