A5101464904- Histone Deacetylase Inhibitors Research
- Cancer Mechanisms and Therapy
- FOXO transcription factor regulation
- Nanoparticles: synthesis and applications
- MicroRNA in disease regulation
- Phosphodiesterase function and regulation
- Epigenetics and DNA Methylation
- Urological Disorders and Treatments
- Circular RNAs in diseases
- Cancer-related gene regulation
- Bacterial biofilms and quorum sensing
- Urologic and reproductive health conditions
- RNA Interference and Gene Delivery
- Melanoma and MAPK Pathways
- Cell death mechanisms and regulation
- Peptidase Inhibition and Analysis
- Mast cells and histamine
- Virus-based gene therapy research
- Protein Degradation and Inhibitors
- Vascular Malformations and Hemangiomas
- Receptor Mechanisms and Signaling
Sun Yat-sen Memorial Hospital
2013-2020
Sun Yat-sen University
2013-2020
Shaanxi Provincial People's Hospital
2020
Research Medical Center
2019
Shanxi Medical University
2018
Shaanxi Provincial People's Hospital
2018
Cedars-Sinai Medical Center
2007
Stanford University
1995
Abstract Tumor suppressor genes are often silenced in human cancer; this can occur by transcriptional repression deacetylation the promoter regions, mediated histone deacetylase (HDAC). HDAC inhibitors block cancer cell growth restoring expression of tumor genes. In study, we investigated effects a inhibitor, suberoylanilide hydroxamic acid (SAHA) on pancreatic cells. SAHA inhibited 6 lines dose‐dependent manner as measured MTT and clonogenic assays (ED 50 ≈10 −6 M) associated with induction...
Discovery of cancer genes through interrogation genomic dosage is one the major approaches in research. In this study, we report that phosphodiesterase subtype 4D (PDE4D) gene was homozygously deleted 198 cases 5,569 primary solid tumors (3.56%), with most being internal microdeletions. Unexpectedly, microdeletions did not result loss their products. Screening PDE4D expression 11 different types tumor samples ( n = 165) immunohistochemistry staining revealed its protein levels were...
Magnetite hybrid nanocomplexes are fabricated to eliminate bacteria and enhance biofilm disruption in the presence of a magnetic field.
Melanoma a common skin tumor induced by excessive hyperplasia of abnormal melanocyte. Circular RNAs (circRNAs) play critical roles in various diseases and presented as the prognostic markers melanoma. The present study was designed to confirm effect circ 0001591 on human melanoma cell growth elucidate its mechanism. Patient with obtained from Shaanxi Provincial People’s Hospital. Cell viability A2058 detected MTT assay. expression serum patients increased. Up-regulation promoted invasion,...
Objective To improve the understanding of cavernous lymphatic malformation (CLM) vulva. Methods The clinical manifestations, histopathological and immunohistochemical features a case CLM involving bilateral labia minora were analyzed, relevant literatures reviewed. Results A 17-year-old unmarried female patient presented with gradually enlarged subcutaneous masses on for 2 years. Physical examination showed that soft kidney-shaped observed minora. After surgical resection,...
Abstract Background: Super-enhancers (SEs) are large clusters of transcriptionally active enhancers. Functionally, they capable driving the expression key genes that control cell identity, which also particularly important for tumor biology. This study is aimed at probing biological function and mechanisms hyper-activation SEs associated core transcriptional regulatory circuitry (CRC) constituted by FOXA1-MAX-SP1 in hepatocellular carcinoma. Results: ChIP-seq analysis H3K27ac showed three...