A5100427368- Micro and Nano Robotics
- Spinal Fractures and Fixation Techniques
- Bone fractures and treatments
- Pelvic and Acetabular Injuries
- Orthopaedic implants and arthroplasty
- Knee injuries and reconstruction techniques
- Hip and Femur Fractures
- Total Knee Arthroplasty Outcomes
- Hormonal and reproductive studies
- Molecular Communication and Nanonetworks
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Orthopedic Surgery and Rehabilitation
- Cervical Cancer and HPV Research
- CRISPR and Genetic Engineering
- Ferroptosis and cancer prognosis
- Bone Tissue Engineering Materials
- MicroRNA in disease regulation
- Bone Metabolism and Diseases
- Gastric Cancer Management and Outcomes
- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Circular RNAs in diseases
- Microfluidic and Bio-sensing Technologies
Southern Medical University
2015-2025
Nanfang Hospital
2015-2025
Guangzhou Institutes of Biomedicine and Health
2025
Third Affiliated Hospital of Southern Medical University
2025
Sir Run Run Shaw Hospital
2025
First Affiliated Hospital of Fujian Medical University
2025
Fujian Medical University
2025
Nanjing Agricultural University
2025
Zhejiang University
2025
Sun Yat-sen University
2014-2024
Hydrogen therapy is an emerging and highly promising strategy for the treatment of inflammation-related diseases. However, nonpolarity low solubility hydrogen under physiological conditions results in a limited therapeutic effect. Herein, we develop biocompatible magnesium micromotor coated with hyaluronic acid as generator precise rheumatoid arthritis management. The bubbles generated locally not only function propellant motion but also active ingredient reactive oxygen species (ROS)...
Chemodynamic therapy (CDT) is an emerging strategy for cancer treatment based on Fenton chemistry, which can convert endogenous H2O2 into toxic ·OH. However, the limited endocytosis of passive CDT nanoagents with low penetrating capability resulted in unsatisfactory anticancer efficacy. Herein, we propose successful fabrication a self-propelled biodegradable nanomotor system hollow MnO2 nanoparticles catalytic activity active Fenton-like Mn2+ delivery and enhanced CDT. Compared counterparts,...
Abstract Biodegradable microswimmers offer great potential for minimally invasive targeted therapy due to their tiny scale, multifunctionality, and versatility. However, most of the reported systems focused on proof‐of‐concept in vitro level. Here, successful fabrication facile hydrogen‐powered (HPMs) precise active acute ischemic stroke is demonstrated. The hydrogen (H 2 ) generated locally from designed magnesium (Mg) microswimmer functions not only as a propellant motion, but also an...
Inducing neural stem cells to differentiate and replace degenerated functional neurons represents the most promising approach for degenerative diseases including Parkinson's disease, Alzheimer's etc. While diverse strategies have been proposed in recent years, of these are hindered due uncontrollable cell fate device invasiveness. Here, we report a minimally invasive micromotor platform with biodegradable helical Spirulina plantensis (S. platensis) as framework superparamagnetic Fe3O4...
Various strategies have been designed for myotube contraction and skeletal muscle stimulation in recent years, aiming the field of tissue engineering bionics. However, most current approaches lack controllability adaptability precise stimulation, especially at microlevel. Herein, wireless activation by using magnetic biohybrid microswimmers combination with near-infrared (NIR) laser irradiation is successfully demonstrated. Biohybrid are fabricated dip-coating superparamagnetic Fe3O4...
Hemophilic articular cartilage damage presents a significant challenge for surgeons, characterized by recurrent intraarticular bleeding, severe inflammatory microenvironment, and limited self-repair capability of tissue. Currently, there is lack tissue engineering-based integrated therapies that address both early hemostasis, anti-inflammation, long-lasting chondrogenesis hemophilic defects. Herein, we developed an adhesive hydrogel using oxidized chondroitin sulfate gelatin, loaded with...
Atherosclerosis is a major cardiovascular disease that causes ischemia of the heart, brain, or extremities, and can lead to infarction. The hypolipidemic agent atorvastatin calcium (Ato) alleviates atherosclerosis by reducing plasma lipid inflammatory factors. However, low bioavailability Ato limits its widespread use clinical effectiveness. Curcumin (Cur), natural polyphenol with antioxidation anti-inflammation bioactivities, has potential anti-atherosclerosis activity may reduce...
Abstract Liver fibrosis, as one of the leading causes liver‐related morbidity and mortality, has no Food Drug Administration (FDA)‐approved antifibrotic therapy yet. Although microRNA‐29b (miRNA‐29b) microRNA‐122 (miRNA‐122) have great potential in treating liver fibrosis via regulating profibrotic genes hepatic stellate cells (HSCs), it is still a challenge to achieve HSC‐targeted meanwhile noninvasively trackable delivery miRNAs vivo. Herein, pH‐sensitive vitamin A (VA)‐conjugated...
Highlights•MADR enables single-locus somatic genetic modification and lineage tracing in vivo•MADR can be used to interrogate the dosage response of transgenes allows "personalized" brain tumor modeling vivo via CRISPR variants or transgenes•MADR is adaptable hundreds available mouse linesSummaryIn situ transgenesis methods such as viruses electroporation rapidly create transgenic mice but lack control over copy number, zygosity, locus specificity. Here we establish mosaic analysis by dual...
Abstract Micro/nanomotors are revolutionary miniaturized robotic systems capable of converting diverse energy sources, including light, ultrasound, and thermal heat, into mechanical motion. This fascinating research area is emerging developing at a rapid pace, demonstrating potential in multiple fields. While their locomotion momentum capabilities have been explored medical treatments, microsurgery diagnosis, the aspect intrinsic energies usable forms remains unexplored. Here, we proposed...
Inspired by the tactic organisms in Nature that can self-direct their movement following environmental stimulus gradient, we proposed a DNase functionalized Janus nanoparticle (JNP) nanomotor system for first time, which be powered ultralow nM to μM levels of DNA. The exhibited interesting chemotactic behavior toward DNA richer area, is physiologically related with many diseases including tumors. In presence subtle gradient generated apoptotic tumor cells, cargo loaded nanomotors were able...
Diabetes is a metabolic disorder characterized by hyperglycemia due to defective insulin secretion or its biological dysfunction. However, frequent subcutaneous injection of often results in discomfort and local tissue infection. Herein, we demonstrate the successful fabrication mini-tablet system based on self-propelled micromotors with biocompatibility biodegradability for oral colon administration insulin. The layer first constructed onto surface magnesium micromotor via electrostatic...
Abstract The importance of mechanical signals in regulating the fate macrophages is gaining increased attention recently. However, recently used normally rely on physical characteristics matrix with non‐specificity and instability or loading devices uncontrollability complexity. Herein, we demonstrate successful fabrication self‐assembled microrobots (SMRs) based magnetic nanoparticles as local signal generators for precise macrophage polarization. Under a rotating field (RMF), propulsion...
Abstract Rheumatoid arthritis (RA) progression involves multiple cell types, and sequential drug action on target cells is necessary for RA treatment. Nanocarriers are widely used treatment; however, the targeted delivery on‐demand release of drugs remains challenging. Therefore, in this study, a dual‐sensitive polymer developed using chondroitin sulfate (CS) co‐delivery cartilage repair agent, glucosamine (GlcN), anti‐inflammatory drug, tofacitinib (Tof). In joint cavity, acidic pH...
A powerful tool for postgenomic analysis of mammalian gene function is targeting in mouse ES cells. We report that homologous recombination using a promoterless trap vector (“targeting trapping”) yields frequencies averaging above 50%, significant increase compared with current approaches. These high appear to be due the stringency selection constructs, because most random insertions are silent and eliminated by drug selection. The design requires targeted expressed cells at levels exceeding...
The abuse of antibiotics in human medicine and animal husbandry leads to the enrichment antibiotic residues aquatic environments, which has been a major problem environmental pollution over past decades. Therefore, it is urgent develop highly efficient approach remove from environments. Inspired by motion characteristics semiconductor-based micro-/nanomotors, light-driven Au-ZnO nanomotor system based on vertically aligned ZnO arrays successfully developed for enhanced photocatalytic...
Little research has been done to test the usefulness of T-lymphoma invasion and metastasis 1 (Tiam1) as a prognostic marker for hepatocellular carcinoma (HCC). In this study, we investigated Tiam1 expression its value HCC. HCC surgical tissue samples were taken from 152 patients who had followed up 5 years. Overexpression (Tiam1 2+ 3+) was shown in 63.8% cases. The level did not correlate with any clinicopathological parameters. However, survival analysis showed that overexpression group...
The inexpensive hypolipidemic drug simvastatin (SIM), which promotes bone regeneration by enhancing morphogenetic protein 2 (BMP-2) expression, has been regarded as an ideal alternative to BMP-2 therapy. However, SIM low bioavailability and may induce the upregulation of BMP-2-antagonistic noggin protein, greatly limits osteogenic effect. Here, a pH-sensitive copolymer, monomethoxy-poly(ethylene glycol)-b-branched...
The imbalance induced by inhibition of bone mesenchymal stem cell (BMSC) osteogenic differentiation results in osteoporosis (OP); however, the underlying regulatory mechanism is not completely understood. Long non‑coding RNAs (lncRNAs) serve crucial roles differentiation; therefore, investigating their role process may identify a promising therapeutic target for OP. expression small nucleolar RNA host gene 1 (SNHG1), Dickkopf (DKK1), microRNA (miR)‑101, RUNX family transcription factor 2...